Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction amplitude of wave I auditory brainstem response (ABR) to high-level stimuli, whereas at threshold unaffected. The aim present study was determine if this prevalent young adult humans with normal audiometric hearing. One hundred and twenty six participants (75 females) aged 18–36 were tested. Participants had wide range lifetime noise...

In rodents, exposure to high-level noise can destroy synapses between inner hair cells and auditory nerve fibers, without causing cell loss or permanent threshold elevation. Such "cochlear synaptopathy" is associated with amplitude reductions in wave I of the brainstem response (ABR) at moderate-to-high sound levels. Similar ABR results have been reported humans tinnitus normal audiometric thresholds, leading suggestion that these cases might be a consequence synaptopathy. However, an...

In rodents, noise exposure can destroy synapses between inner hair cells and auditory nerve fibers ("cochlear synaptopathy") without causing cell loss. Noise-induced cochlear synaptopathy usually leaves thresholds unaltered, but is associated with long-term reductions in brainstem response (ABR) amplitudes at medium-to-high sound levels. This pathophysiology has been suggested to degrade speech perception (SPiN), perhaps explaining why SPiN ability varies so widely among audiometrically...

An estimate of lifetime noise exposure was used as the primary predictor performance on a range behavioral tasks: frequency and intensity difference limens, amplitude modulation detection, interaural phase discrimination, digit triplet speech test, co-ordinate response measure, an auditory localization task, musical consonance task subjective report hearing ability. One hundred thirty-eight participants (81 females) aged 18–36 years were tested, with wide self-reported exposure. All had...

Cochlear synaptopathy (or hidden hearing loss), due to noise exposure or aging, has been demonstrated in animal models using histological techniques. However, diagnosis of the condition individual humans is problematic because (a) test reliability and (b) lack a gold standard validation measure. Wave I transient-evoked auditory brainstem response noninvasive electrophysiological measure nerve function validated models. humans, amplitude shows high variability both between within individuals....

The temporal envelope of speech is important for intelligibility. Entrainment cortical oscillations to the a putative mechanism underlying Here we used magnetoencephalography (MEG) test hypothesis that phase-locking enhanced intelligible compared with unintelligible sentences. Perceptual "pop-out" was change percept physically identical tone-vocoded sentences from intelligible. use pop-out dissociates changes in arising acoustical differences between un/intelligible intelligibility itself....

The auditory brainstem response (ABR) is a sub-cortical evoked potential in which series of well-defined waves occur the first 10 ms after onset an stimulus. Wave V ABR, particularly wave latency, has been shown to be remarkably stable over time individual listeners. However, little attention paid reliability I, reflects nerve activity. This ABR component attracted interest recently, as I amplitude identified possible non-invasive measure noise-induced cochlear synaptopathy. current study...

Verbal communication in noisy backgrounds is challenging. Understanding speech background noise that fluctuates intensity over time particularly difficult for hearing-impaired listeners with a sensorineural hearing loss (SNHL). The reduction fast-acting cochlear compression associated SNHL exaggerates the perceived fluctuations amplitude-modulated sounds. SNHL-induced changes coding of sounds may have detrimental effect on ability to understand presence modulated noise. To date, direct...

Although there is strong histological evidence for age-related synaptopathy in humans, the existence of noise-induced cochlear humans inconclusive. Here, we sought to evaluate relative contributions age and noise exposure using a series electrophysiological behavioral measures. We extended an existing cohort by including 33 adults range 37 60, resulting total 156 participants, with additional older participants weakening correlation between lifetime age. used six independent regression...

Musicians are at risk of hearing loss due to prolonged noise exposure, but they may also be early sub-clinical damage, such as cochlear synaptopathy. In the current study, we investigated effects exposure on electrophysiological, behavioral and self-report correlates damage in young adult (age range = 18-27 years) musicians non-musicians with normal audiometric thresholds. Early-career (n 76) 47) completed a test battery including Noise Exposure Structured Interview, pure-tone audiometry...

Musicians are at risk of hearing loss and tinnitus due to regular exposure high levels noise. This level may have been underestimated previously since damage the auditory system, such as cochlear synaptopathy, not be easily detectable using standard clinical measures. Most previous research investigating in musicians has involved cross-sectional study designs that capture only a snapshot health relation noise exposure. The aim this was investigate effects cumulative on behavioural,...

Investigations of cochlear synaptopathy in living humans rely on proxy measures auditory nerve function. Numerous procedures have been developed, typically based the brainstem response (ABR), envelope-following (EFR), or middle-ear-muscle reflex (MEMR). Validation is challenging, due to absence a gold-standard measure humans. Some metrics correlate with synaptic survival animal models, but translation between species not straightforward; measurements are likely reflect greater error and...

Background Behavioural studies have highlighted irregularities in recognition of facial affect children and young people with autism spectrum disorders (ASDs). Recent findings from utilising electroencephalography (EEG) magnetoencephalography (MEG) identified abnormal activation irregular maintenance gamma (>30 Hz) range oscillations when ASD individuals attempt basic visual auditory tasks. Methodology/Principal Fndings The pilot study reported here is the first to use spatial filtering...

The aims of this study were to systematically explore the effects stimulus duration, background (quiet versus noise), and three consonant-vowels on speech-auditory brainstem responses (ABRs). Additionally, minimum number epochs required record speech-ABRs with clearly identifiable waveform components was assessed. purpose evaluate whether shorter duration stimuli could be reliably used both in quiet noise consonant-vowels, as opposed longer that are commonly literature. Shorter a smaller...

An unresolved goal in face perception is to identify brain areas involved processing and simultaneously understand the timing of their involvement. Currently, high spatial resolution imaging techniques fusiform gyrus as subserving invariant features relating identity. High temporal localize an early latency evoked component-the N/M170-as having a major generator region; however, this component not believed be associated with To resolve this, we used novel magnetoencephalographic beamformer...

The acoustic reflex (AR) shows promise as an objective test for the presence of cochlear synaptopathy in rodents. AR has also been shown to be reduced humans with tinnitus compared those without. aim present study was twofold: (a) determine if strength (quantified both threshold and growth) varied lifetime noise exposure, thus provided estimate degree (b) identify which factors should considered when using a quantitative measure rather than just present/absent responses. thresholds growth...

Purpose: Many workers in developing countries are exposed to unsafe occupational noise due inadequate health and safety practices. We tested the hypotheses that exposure aging affect speech-perception-in-noise (SPiN) thresholds, self-reported hearing ability, tinnitus presence, hyperacusis severity among Palestinian workers. Method: ( N = 251, aged 18–70 years) without diagnosed or memory impairments completed online instruments including a questionnaire; forward backward digit span tests;...