A5008548693- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Geophysical Methods and Applications
- Pancreatic and Hepatic Oncology Research
- Pelvic floor disorders treatments
- Viral-associated cancers and disorders
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Infrastructure Maintenance and Monitoring
- Seismic Waves and Analysis
- Non-Destructive Testing Techniques
- Cancer Genomics and Diagnostics
- Anorectal Disease Treatments and Outcomes
- Gastric Cancer Management and Outcomes
- Microwave Imaging and Scattering Analysis
- Cancer Immunotherapy and Biomarkers
- Rock Mechanics and Modeling
- Ultrasonics and Acoustic Wave Propagation
- Chronic Lymphocytic Leukemia Research
Sun Yat-sen University
2018-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2024
Guangzhou University
2022-2023
Importance Previous studies have demonstrated the advantages of short-term histopathological outcomes and complications associated with transanal total mesorectal excision (TME) compared laparoscopic TME. However, long-term oncological TME remain ambiguous. This study aims to compare 3-year disease-free survival Objective To evaluate between in patients rectal cancer. Design, Setting, Participants randomized, open-label, noninferiority, phase 3 clinical trial was performed 16 different...
Importance: Patients with pCR of rectal cancer following neoadjuvant treatment had better oncological outcomes. However, reliable methods for accurately predicting remain limited. Objective: To evaluate whether transrectal ultrasound-guided tru-cut biopsy (TRUS-TCB) adds diagnostic value to conventional modalities pathological complete response (pCR) in patients after treatment. Design, Setting, and Participants: This study evaluated data who were treated reassessed using TRUS-TCB before...
Abstract Purpose The prognostic value of the mucinous adenocarcinoma histotype on early stages especially for stage I colorectal cancer (CRC) is still unclear. This study determined clinicopathologic characteristics and long-term outcome adenocarcinomas (MAC). Methods Among total 530 patients with CRC (58 having MAC 472 non-MAC) who underwent radical resection, correlation between clinicopathological factors was analyzed. Multivariate analysis performed to determine whether itself an...
Systemic inflammatory responses are associated with the prognosis of patients colorectal cancer. However, value in predicting tumor to neoadjuvant chemoradiotherapy (nCRT) remains be elucidated. The current study aimed investigate association between systemic indices and pathological complete response (pCR). training validation cohorts included 225 96 locally advanced rectal neutrophil‑to‑lymphocyte ratio (NLR) platelet‑to‑lymphocyte were recorded prior nCRT radical surgery. Univariate...
Approximately 15-30% of locally advanced rectal cancer (LARC) patients achieved pathological complete response (pCR) after neoadjuvant chemoradiotherapy (CRT) and total mesorectal excision, but the clinical significance adjuvant chemotherapy (ACT) for pCR remains unclear.To determine whether LARC can benefit from administration ACT.Single center retrospective study.This study retrospectively included 280 who CRT surgery 2011 to 2019. The information was recorded. Main outcome measures 5-year...
Lymphocytic density in rectal cancer has been reported to be associated with therapeutic response, but the role of lymphocytic distribution pattern remains determined. This study aimed evaluate association between and lymphocytes rectal-cancer tissue tumor response neoadjuvant therapy. We retrospectively analysed 134 patients receiving therapy within a prospectively maintained cohort. Pretherapeutic biopsy samples were stained immunohistochemistry (CD4 CD8). Densities intratumoral...
<title>Abstract</title> Background The incidence of rectal neuroendocrine tumors (RNETs) has witnessed a significant surge, with notable proportion being amenable to endoscopic removal. However, the clinical significance positive resection margin for RNETs patients following remain unknown, resulting in lack consensus regarding appropriateness implementing salvage treatment. Methods In this large, multicenter, retrospective cohort study, we analyzed medical records individuals who underwent...
Sidestream dark field (SDF) imaging is a tool for assessing microcirculation, commonly used early diagnosis and monitoring of sepsis. In this study, we SDF to observe assess the microcirculation intestinal mucosa during bowel surgery. We also compared different performance between normal diseased using imaging. was conducted in 13 patients evaluate parameters. All were assessed at distances 0, 1, 2, 3 4 centimeters (cm) from edge mesentery, respectively. Microcirculatory parameters such as...
Deficient mismatch repair (dMMR) or microsatellite instability is one of the well-established molecular biomarkers in colorectal cancer (CRC). The efficiency neoadjuvant chemotherapy (NAC) locally advanced (LACC) patients with dMMR unclear.We assessed tumor response and clinical outcome LACC received NAC.Retrospective, single-center analysis.From 2013 to 2018, a total 577 who underwent radical surgery were identified. Among them, 109 adjuvant further screened out for analysis. According...
For patients with locally advanced rectal cancer (LARC) pathological complete response (pCR), the clinical significance of distribution extent acellular mucin pools (AMP) remains unclear, so this study was conducted to address key unanswered questions. We performed a retrospective analysis 317 LARC pCR after preoperative chemoradiotherapy and total mesorectal resection from January 2011 June 2020. Based on AMP existence deepest tissue layer distribution, were assigned new stages. The patient...
As a recognized non-destructive testing method, ground penetrating radar (GPR) has been widely applied for hidden defect detection of railway tunnels. However, the manual interpretation GPR data is time-consuming and high demand operator's experience. This paper presents an automatic recognition algorithm, which based on faster region-based convolutional neural network (Faster R-CNN), to recognize defects behind tunnel lining, including non-compactness, voids with air- or water-filled,...
Abstract As a recognized non-destructive testing (NDT) method, ground penetrating radar (GPR) has been applied for void detection in shield tunnel. However, due to the complex structures of segment with double-layer rebar meshes inside, GPR responses voids behind are still not clear. This paper presents series laboratory experiments analyze and characterize based on platform which is composed two 1:1 scale segment. Results preliminarily show that low-frequency signals from near-segment less...
222 Background: Mucinous carcinoma (MC), accounting for 10-15% of colorectal cancer (CRC), has long been associated with an inferior response to treatment. MC as unfavorable prognostic factor in early stage CRC remains questionable. In this study, we used a large cohort define the genomic landscape and identify clinically actionable information. Methods: The 1226 patient included 997 adenocarcinomas (AC), 129 MC, 110 mucous composition (AMC). All pathological sections were verified by...
Abstract Background : The prognostic value of the mucinous adenocarcinoma histotype on early stages especially for stage I colorectal cancer (CRC) is still unclear. This study determined clinicopathologic characteristics and long-term outcome adenocarcinomas (MAC).Methods Among total 503 patients with CRC (56 having MAC 447 non-MAC) who underwent radical resection, correlation between clinicopathological factors was analyzed. Multivariate analysis performed to determine whether itself an...
Abstract Background : The prognostic value of the mucinous adenocarcinoma histotype on early stages especially for stage I colorectal cancer (CRC) is still unclear. This study determined clinicopathologic characteristics and long-term outcome adenocarcinomas (MAC). Methods Among total 503 patients with CRC (56 having MAC 447 non-MAC) who underwent radical resection, correlation between clinicopathological factors was analyzed. Multivariate analysis performed to determine whether itself an...