A5069353464- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Anorectal Disease Treatments and Outcomes
- Peptidase Inhibition and Analysis
- Enhanced Recovery After Surgery
- Pharmacological Effects of Natural Compounds
- Digestive system and related health
Sixth Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Key Laboratory of Guangdong Province
2019-2022
Nanjing Agricultural University
2020
Peking University
2014-2019
Second Military Medical University
2019
University of California, Davis
2019
Fred Hutch Cancer Center
2011-2017
University of Washington
2016
Peking University Sixth Hospital
2014
Background Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, can be used for predicting immunotherapy responsiveness and survival outcome. However, the evaluation of TILs currently relies on histopathological methodology with high variability. We therefore aimed to develop a DNA methylation signature (CD8+ MeTIL) that could evaluate immune response prognosis in colorectal cancer (CRC). Methods A MeTIL score was constructed by using T cell-specific differentially methylated...
Patients with peritoneal metastasis (PM) of colorectal cancer (CRC) have poorer overall survival outcomes than those without PM. Cancer-associated fibroblasts (CAFs) are a major component the tumor microenvironment and mediate CRC progression It is imperative to identify develop novel therapeutic targets for PM-CRC driven by CAFs. Using lipidomics, we reveal that abundance phosphatidylcholine (PC) unsaturated acyl chains was increased in clinical specimens. Additionally, found CAFs were...
More than ten randomized clinical trials are being tested to evaluate the efficacy, effectiveness and safety of a fasting-mimicking diet (FMD) combined with different antitumor agents.UMI-mRNA sequencing, Cell-cycle analysis, Label retention, metabolomics, Multilabeling et al. were used explore mechanisms. A tandem mRFP-GFP-tagged LC3B, Annexin-V-FITC Apoptosis, TUNEL, H&E, Ki-67 animal model was search for synergistic drugs.Here we showed that fasting or FMD retards tumor growth more...
Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. Cancer-associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need new treatment strategies. Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T coculture, crystal violetstaining, ELISA, metabonomic clinical tumour samples were...
NTRK3 is a member of the neurotrophin receptor family and regulates cell survival. It appears to be dependence receptor, thus has potential act as an oncogene or tumor suppressor gene. for NT-3 when bound it induces survival, but free, apoptosis. We identified aberrantly methylated in colorectal cancers through genome-wide screen hypermethylated genes. This discovery led us assess whether could gene colon. 60% colon adenomas 67% adenocarcinomas. methylation suppresses expression....
Alterations in DNA methylation have been proposed to create a field cancerization state the colon, where molecular alterations that predispose cells transformation occur histologically normal tissue. However, our understanding of role is limited by an incomplete characterization colon. In order determine colon's state, we extracted from colon biopsies rectum, sigmoid, transverse, and ascending assessed status pyrosequencing candidate loci as well with HumanMethylation450 arrays. We found...
Abstract Background Chronological age is a prominent risk factor for many types of cancers including colorectal cancer (CRC). Yet, the CRC varies substantially between individuals, even within same group, which may reflect heterogeneity in biological tissue aging people. Epigenetic clocks based on DNA methylation are useful measure process with potential to serve as biomarker an individual’s susceptibility age-related diseases such CRC. Methods We conducted genome-wide study samples normal...
Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase receptor, has been identified as proto-oncogene in multiple cancers. The CSF1/CSF1R axis is essential for the survival and differentiation of M2-phenotype tumor-associated macrophages (M2 TAMs). However, we found here that CSF1R expression was abnormally down-regulated colorectal cancer (CRC), its biological functions underlying mechanisms have become elusive CRC progression. Methods class III kinases normal...
Background Nuclear factor κB (NFκB) plays a key role in the regulation of apoptosis. The function NFκB is inhibited by binding to inhibitor (IκB), and disruption balance IκB related development many diseases, including tumors. Therefore, we hypothesized that NFκB1 (-94del/insATTG) NFκBIA (2758 A>G) polymorphisms were associated with colorectal cancer (CRC) susceptibility. Methods In hospital-based case–control study 1001 CRC patients 1005 cancer-free controls frequency matched age sex,...
Maladaptive memories elicited by exposure to environmental stimuli associated with drugs of abuse are often responsible for relapse among addicts. Interference the reconsolidation drug memory can inhibit seeking. Previous studies have indicated that dephosphorylation eukaryotic initiation factor 2 α-subunit (eIF2α) plays an important role in synaptic plasticity and long-term consolidation, but its remains unknown. The amygdala is required a destabilized after retrieval drug-paired stimuli....
Background: Immune checkpoint inhibitor (ICI) treatment in patients with microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) tumors holds promise reshaping organ preservation rectal cancer. However, the benefits are accompanied by distinctive patterns of response, introducing a dilemma response evaluation for clinical decision-making. Patients and Methods: locally advanced cancer MSI-H/dMMR receiving neoadjuvant ICI (nICI) (n=13) matched chemoradiotherapy (nCRT; n=13) were...
Abstract Background N6‐methyladenosine (m6A) modification is an emerging epigenetic regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) a well‐described m6A demethylase previous enzyme assays, we aimed to investigate the role of methylation alteration conferred by disturbed ALKBH5 colorectal cancer (CRC) development. Methods Expression and its correlation with clinicopathological characteristics CRC were evaluated using prospectively maintained institutional...
Barrett's esophagus (BE) is a metaplastic process whereby the normal stratified, squamous esophageal epithelium replaced by specialized intestinal epithelium. only accepted precursor lesion for adenocarcinoma (EAC), solid tumor that rapidly increasing in incidence western countries. BE evolves into EAC through intermediate steps involve degrees of dysplasia. Current histologic criteria are quite subjective and clinical behavior highly variable difficult to predict using these standards. It...
Deregulation of DNA repair enzymes occurs in cancers and may create a susceptibility to chemotherapy. Expression levels have been shown predict the responsiveness certain chemotherapeutic agents. The RECQ helicases damaged including damage caused by topoisomerase I inhibitors, such as irinotecan. Altered expression these colorectal cancer (CRC) influence response Thus, we assessed helicase (WRN, BLM, RECQL, RECQL4, RECQL5) primary CRCs, matched normal colon, CRC cell lines. We found that BLM...
Human replication factor C4 (RFC4) is involved in DNA as a clamp loader and aberrantly regulated across range of cancers. The current study aimed to investigate the function RFC4 colorectal cancer (CRC).
Periostin (POSTN) expression in cancer cells and circulation has been related to poor prognosis of colorectal carcinoma (CRC). However, the role POSTN expressed intra-tumoral stroma on CRC progression remains largely unknown. This study enrolled 1098 patients who received surgical treatment Shanghai Guangzhou, Mainland China. In cohort, immunohistochemistry score stromal increased consecutively from adjacent mucosa, primary tissues, metastatic tissues (P < 0.001), while medium- high-stromal...
Serum CEA has been widely used to screen for potential recurrent disease after resection in rectal cancer. However, the influence of baseline on performance recurrence surveillance needs be investigated.This longitudinal cohort study included 484 patients with nonmetastatic cancer from 18,013 a prospectively enrolled institutional database program colorectal disease. Baseline levels were determined before treatment, and CEA-based follow-up tests examinations applied treatment.A total 62.6%...
Abstract Background The current risk stratification system defined by clinicopathological features does not identify the of recurrence in early-stage (stage I-II) colorectal cancer (CRC) with sufficient accuracy. We aimed to investigate whether DNA methylation could serve as a novel biomarker for predicting prognosis CRC patients. Methods analyzed genome-wide status CpG loci using Infinium MethylationEPIC array run on primary tumor tissues and normal mucosa patients potential markers...