A5067373934- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Bone health and osteoporosis research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Metabolism, Diabetes, and Cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Surgical Treatments
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
Shenzhen Second People's Hospital
2023-2024
Shanghai Ninth People's Hospital
2021-2023
Sixth Affiliated Hospital of Sun Yat-sen University
2016-2022
Sun Yat-sen University
2016-2022
Key Laboratory of Guangdong Province
2022
Xian Mental Health Center
2021
Union Hospital
2021
Huazhong University of Science and Technology
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2004-2021
People's Liberation Army No. 150 Hospital
2015-2016
MicroRNAs (miRNAs) are dysregulated in a wide range of malignant diseases, confirming their crucial role tumor metastasis. MiRNA-30a-5p, member the miR-30 family, has been implicated many types cancers, including colorectal cancer, leading cause death worldwide.
Most cancer-related deaths result from the progressive growth of metastases. Patients with peritoneal metastatic (PM) colorectal cancer have reduced overall survival. Currently, it is still unclear why (CRC) cells home to and proliferate inside cavity, there no effective consolidation therapy for improved Using a proteomic approach, we found that key enzymes fatty acid oxidation (FAO) were decreased in patients PM cancer. Furthermore, confirmed carnitine palmitoyltransferase IA (CPT1A),...
Patients with peritoneal metastasis (PM) of colorectal cancer (CRC) have poorer overall survival outcomes than those without PM. Cancer-associated fibroblasts (CAFs) are a major component the tumor microenvironment and mediate CRC progression It is imperative to identify develop novel therapeutic targets for PM-CRC driven by CAFs. Using lipidomics, we reveal that abundance phosphatidylcholine (PC) unsaturated acyl chains was increased in clinical specimens. Additionally, found CAFs were...
FAT4, a cadherin-related protein, was shown to function as tumour suppressor; however, its role in human gastric cancer remains largely unknown. Here, we investigated the of FAT4 and examined underlying molecular mechanisms. The expression evaluated by immunohistochemistry, western blotting, qRT–PCR relation clinicopathological characteristics patients. effects silencing on cell proliferation, migration, invasion were assessed MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) assay,...
Abstract The Serine–Glycine–One-Carbon (SGOC) pathway is pivotal in multiple anabolic processes. Expression levels of SGOC genes are deregulated under tumorigenic conditions, suggesting participation oncogenes deregulating the biosynthetic pathway. However, underlying mechanism remains elusive. Here, we identified that Interleukin enhancer-binding factor 3 (ILF3) overexpressed primary CRC patient specimens and correlates with poor prognosis. ILF3 critical regulating by directly mRNA...
Tripartite motif-containing protein 65 (TRIM65) is an E3 ubiquitin ligase and a critical regulator of variety cellular processes as well tumor progression. Therefore, more substrates must be identified in the physiology or disease context. Here, we found that TRIM65 upregulated associated with poor survival colorectal cancer (CRC). More specifically, high expression CRC metastasis recurrence. Ectopic overexpression cell lines enhanced proliferation, invasion, migration, while knockdown had...
To analyze and compare the economic outcomes of adjuvant chemotherapy with capecitabine plus oxaliplatin (referred to as XELOX strategy) S-1 (the for gastric cancer patients after D2 gastrectomy. A Markov model was developed simulate lifetime disease course associated stage II or III The quality-adjusted life years (QALYs), costs, incremental cost-effectiveness ratios (ICERs) were estimated. clinical data derived from results pilot studies. Direct costs estimated perspective Chinese...
Introduction: PD-1 inhibitors have been approved for the treatment of dMMR patients with metastatic colorectal cancer, but efficacy neoadjuvant in locally advanced rectal cancer (LARC) has not yet defined.Patients and methods: Two LARC received Nivolumab as July 2017. Whole-exome sequencing (WES) multiplex immunofluorescence analysis were performed.Results: Of two patients, one achieved pathological complete response after six cycles nivolumab followed by surgery. The other patient was...
Human antigen R (HuR) is an RNA-binding protein that posttranscriptionally regulates many cancer-trait genes. CDC6, a central regulator of DNA replication, regulated by HuR. In this study, we investigated the role HuR in colorectal cancer tumorigenesis and oxaliplatin (L-OHP) resistance, as well underlying mechanisms involving CDC6. We detected increased CDC6 expression, along with positive correlation between two human tissues. overexpression cell proliferation vitro xenograft tumor growth...
TRIM58 is a member of the tripartite motif protein (TRIM) family E3 ubiquitin ligases. Aberrant gene methylation has been reported in liver and lung cancer indicates poor patient prognosis. However, expression level functional role colorectal (CRC) have yet to be elucidated. In present study, we found that was significantly suppressed human CRC inversely correlated with progression. Additionally, overall survival reduced patients low tumors. vitro studies demonstrated ectopic overexpression...
Background The interrelation between glucose and bone metabolism is complex has not been fully revealed. This study aimed to investigate the association insulin resistance, β-cell function turnover biomarker levels among participants with abnormal glycometabolism. Methods A total of 5277 subjects were involved through a cross-sectional (METAL study, http://www.chictr.org.cn , ChiCTR1800017573) in Shanghai, China. Homeostasis model assessment resistance (HOMA-IR) dysfunction (HOMA-%β) applied...
Colorectal cancer (CRC) is often diagnosed at later stages after it has metastasized to other organs. The development of chemoresistance also contributes a poor prognosis. Therefore, an increased understanding the metastatic properties CRC and could improve patient survival. CUGBP elav-like family member 1 (CELF1) RNA-binding protein, which overexpressed in many human malignant tumors. However, influence CELF1 unclear. V-ets erythroblastosis virus E26 oncogene homologue 2 (ETS2)...
Objective: The aim of this study was to build a SVM classifier using ResNet-3D algorithm by artificial intelligence for prediction synchronous PC. Background: Adequate detection and staging PC from CRC remain difficult. Methods: primary tumors in were delineated on preoperative contrast-enhanced computed tomography (CT) images. features adjacent peritoneum extracted ResNet3D + classifier. performance evaluated the test set compared routine CT which radiologists. Results: training consisted...
Circular RNAs (circRNAs) and long noncoding (lncRNAs) have been considered as biomarkers or regulators in many diseases. However, the exact role of circRNA- lncRNA-mediated competing endogenous RNA (ceRNA) networks modulation depression pathogenesis-relevant processes is not clear. In this study, we profiled whole transcriptome patients' blood samples via microarray analysis. As a result, total 340 circRNAs, 398 lncRNAs, 206 miRNAs, 92 mRNAs were differentially expressed between control...
// Chun Guang Guo 1 , Dong Bing Zhao Qian Liu Zhi Xiang Zhou Ping Gui Qi Wang 2 Jian Qiang Cai Department of Abdominal Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy Medical Sciences and Peking Union College, Beijing, China Endoscopy, Correspondence to: Zhao, email: dbzhao2003@sina.com Wang, wangguiq@126.com Keywords: gastric cancer, lymph node metastasis, nomogram, endoscopic resection, decision analysis Received: April 05, 2016 ...
Aberrant expression of choline kinase alpha (CHKA) has been reported in a variety human malignancies including colorectal carcinoma (CRC). However, the role CHKA progression and prognosis CRC remains unknown. In this study, we found that was frequently upregulated clinical samples CRC-derived cell lines significantly correlated with lymph node metastasis (p = 0.028), TNM stage 0.009), disease recurrence 0.004) death < 0.001). Survival analyses indicated patients higher had shorter...
Carbonic anhydrases (CAs) have been implicated in the pathogenesis of human cancers. anhydrase VII (CA7), a member CA gene family, was recently demonstrated to be expressed several tissues including colon. Nevertheless, expression and clinical relevance CA7 colorectal carcinoma (CRC) has not investigated.Real-time PCR, western blot, immunohistochemistry analyses were used determine CRC samples. The correlation with clinicopathologic features assessed 228 patients from Luoyang, China...
Neuropilin and tolloid-like 2 (NETO2) has been found to be overexpressed in different human cancers, but its expression pattern clinical relevance colorectal carcinoma (CRC) remains unknown. Real-time quantitative PCR, western blot immunohistochemistry analyses were used analyze the of NETO2 CRC samples. The correlation with clinicopathologic features was estimated a cohort containing 292 patients primary CRC. Kaplan-Meier Cox proportional hazards regression assess prognostic value...
BACKGROUND Doxorubicin (DOX) is a potent chemotherapeutic agent used to treat colon cancer. Despite impressive initial clinical responses, drug resistance has dramatically compromised the effectiveness of DOX. However, underlying mechanisms in cancer remain poorly understood. MATERIAL AND METHODS In this study, we compared expression miR-222-3p DOX-resistant cells (LoVo/ADR) with corresponding DOX-sensitive parental (LoVo/S) using quantitative real-time PCR. addition, inhibitors were...
Abstract Background The screening biomarkers for early detection of colorectal cancer (CRC) is lacking. aim to identify epigenetic silenced genes and clarify its roles underlying mechanism in CRC. We conducted integrative analyses epigenome-wide Human Methylation 450 K arrays transcriptome screen out candidate driver with transcription silencing. Methylated silencing HAND2 were identified verified large CRC cohort. expression by promoter inhibition clarified both vitro vivo assays. Cell...
Certain nickel compounds including crystalline sulfide (NiS) and subsulfide (Ni3S2) are potent human animal carcinogens. In Chinese hamster embryo cells, an X-linked senescence gene was inactivated following nickel-induced DNA methylation. Nickel also induced the inactivation of gpt reporter by chromatin condensation a methylation process in transgenic gpt+ cell line (G12), which is located near heterochromatic region. To determine if can cause silencing independently methylation, based only...