Abstract Pelvic organ prolapse (POP) is one of the most common pelvic floor dysfunction disorders worldwide. The weakening connective tissues initiated by excessive collagen degradation a leading cause POP. However, patches currently used in clinic trigger an unfavorable inflammatory response, which often leads to implantation failure and inability simultaneously reverse progressive degradation. Therefore, overcome present challenges, new strategy applied introducing puerarin (Pue) into...

Colorectal cancer (CRC) is often diagnosed at later stages after it has metastasized to other organs. The development of chemoresistance also contributes a poor prognosis. Therefore, an increased understanding the metastatic properties CRC and could improve patient survival. CUGBP elav-like family member 1 (CELF1) RNA-binding protein, which overexpressed in many human malignant tumors. However, influence CELF1 unclear. V-ets erythroblastosis virus E26 oncogene homologue 2 (ETS2)...

Synchronous peritoneal metastasis (S-PM) is considered a poor prognostic factor for colorectal cancer (CRC) and there no nomogram to predict the survival of these patients. In this study, we aimed use multicenter data identify factors associated with S-PM CRC construct predicting overall (OS) patients.CRC patients from two medical centers were enrolled between September 2007 June 2017. Multivariate analysis was used independent OS 1-, 2-, 3-year rates in development group. The concordance...

Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women. Weakening pelvic ligaments plays an essential role in pathophysiology POP. Currently, synthetic materials are widely applied for reconstructive surgery. However, nondegradable meshes POP therapy cannot meet clinical requirements due to its poor biocompatibility. Herein, we fabricated electrospun core–shell nanofibers poly(l-lactic acid)-hyaluronic acid (PLLA/HA). After that, combined them...

Creation of a temporary diverting stoma during rectal cancer surgery is used widely to prevent undesirable outcomes related anastomotic leakage (AL). The transition from (TS) permanent (PS) frequent outcome. Elderly patients may have greater probability PS. We aimed identify risk factors PS and developed nomogram predict the rate for elderly patients.We enrolled (≥70 years) who underwent with TS between January 2014 December 2017 at our hospital. divided into two groups: group group. then...

Treatment of colorectal cancer (CRC) with synchronous peritoneal metastases (SPM) is controversial, and its prognosis remains poor. Here, we analysed the association between treatment strategies outcomes patients SPM devised a nomogram to improve their prediction. We retrospectively treated at The Sixth Affiliated Hospital, Sun Yat-sen University from June 2007 2018. Kaplan-Meier method log-rank tests was used compare overall survival (OS) among undergoing different therapeutic regimens. Cox...

Small bowel involvement is related to poor prognosis in Crohn's disease (CD), which may be a potential marker stratify patients with high risk of progression. This study aimed establish novel location classification system for CD and develop predictive model Consecutive non-stricturing/non-penetrating were retrospectively included the Sixth Affiliated Hospital, Sun Yat-sen University (Guangzhou, P. R. China) between January 2012 2018. Patients classified into two groups according location:...

Surgical-site infection (SSI) was one of the most common post-operative morbidities ileostomy reversal. Although several skin-closure procedures had been developed to reduce rate SSI, optimal procedure remains unclear. In this study, we compared effect two surgical techniques for wound closure following reversal: gunsight suture (GS) and linear (LS).A total 233 patients who underwent loop at Sixth Affiliated Hospital Sun Yat-sen University between January 2015 December 2017 were enrolled...

The transsacrococcygeal (TSC) approach in rectal gastrointestinal stromal tumour (GIST) resection is clinically challenging and controversial, we evaluated its value the present study.We enrolled patients who underwent GIST by TSC during 2008-2018. clinicopathological index, surgical outcome, prognosis were analysed. Prognostic information was obtained from medical records follow-up data. Anal function low anterior syndrome (LARS) score.Among 88 over 10-year study period, 17 median age 55...

Purpose The prognostic value of desmoplastic reaction (DR) has not been investigated in colorectal cancer (CRC) patients with synchronous peritoneal metastasis (SPM). present study aimed to identify whether DR can predict overall survival (OS) and develop a novel nomogram. Methods CRC SPM were enrolled from single center between July 2007 2019. patterns primary tumors classified as mature, intermediate, or immature according the existence absence keloid-like collagen myxoid stroma. Cox...

The early diagnosis of occult peritoneal metastasis (PM) remains a challenge due to the low sensitivity on computed tomography (CT) images. Exploratory laparoscopy is gold standard confirm PM but should only be proposed in selected patients its invasiveness, high cost, and port-site risk. In this study, we aimed develop an individualized prediction model identify status determine optimal candidates for exploratory laparoscopy. A total 622 colorectal cancer (CRC) from 2 centers were divided...

To date, the value of hyperthermic intraperitoneal chemotherapy (HIPEC) following up-front resection for isolated synchronous colorectal peritoneal metastases seems controversial. This retrospective cohort study was conducted from September 1, 2012, to 2019, at a tertiary medical center in China. Patients with were included CRS plus HIPEC group or alone based on treatment history. Overall survival and relapse-free estimated using Cox proportional hazards regression analysis Kaplan-Meier...

14 Background: Peritoneal carcinomatosis (PC) of colorectal cancer remain poor and is considered to be the terminal stage. Early detection PC can bring survival benefit for chances complete cytoreductive surgery. In this study, we have developed validated a CT-based nomogram preoperative prediction synchronous in CRC. Methods: The optimized image classification was large cohort. specific features were extracted from CT arterial stage scans by radiologists. A model constructed Boruta...

KRAS/BRAF mutations (mutKRAS/mutBRAF) are unfavorable prognostic factors for colorectal cancer (CRC) metastases to the liver and lungs. However, their effects on prognosis patients with synchronous peritoneal metastasis (S-PM) of CRC after cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) controversial. In study, we aimed determine mutKRAS/mutBRAF S-PM who received CRS.A total 142 diagnosed between July 2007 2019 were included in this study. The demographics,...

Functionalized biomaterials have potential applications in the diagnosis and treatment of peritoneal surface malignancies. The imagery a starry sky background serves as metaphor for vast opportunities exploration within this field. ellipses depicted symbolize trajectories diagnosis, respectively. round balls represent various representative materials, such gel-based drug delivery systems fluorescent nanomaterials. Furthermore, presence scattered protuberant stones signifies existence...

Microsatellite has been proved to be an important prognostic factor and a treatment reference in colon cancer. The transcriptome profile tumor microenvironment of different microsatellite statuses are different. Metastatic cancer patients with instability-high (MSI-H) sensitive immune checkpoint inhibitors (ICIs), but not fluorouracil. Efforts have devoted identify the predictive factors immunotherapy.We analyzed by using single-cell bulk data from publicly available databases. cells were...

Abstract Background: Early detection of synchronous colorectal peritoneal metastasis (CPM) is difficult due to the absence typical symptoms and low accuracy imaging examinations. Better knowledge risk factors for CPM may be essential early diagnosis strengthening management. This study aimed clarify factors. Methods: meta-analysis was based on PRISMA guidelines. A systematic search PubMed, Embase Cochrane Library databases performed. The pooled data assessed by a random-effects model....

Anastomotic leakage after rectal cancer surgery in elderly patients is a critical challenge. Many risk factors have been found and many interventions tried, but anastomotic remains difficult to deal with. This study aimed create nomogram for predicting with dysfunctional stomata.We collected data from 326 consecutive stomata at the Sixth Affiliated Hospital, Sun Yat-Sen University January 2014 December 2019. Risk of were identified multivariate logistic regression used nomogram. Predictive...