A5101719828- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Dental Implant Techniques and Outcomes
- Osteoarthritis Treatment and Mechanisms
- Spinal Cord Injury Research
- Musculoskeletal pain and rehabilitation
- Liver Disease Diagnosis and Treatment
- Hernia repair and management
- Nerve injury and regeneration
- Fatty Acid Research and Health
- RNA Research and Splicing
- Orthopedic Infections and Treatments
- Dental materials and restorations
- Cancer-related molecular mechanisms research
- Knee injuries and reconstruction techniques
- Polymer Surface Interaction Studies
- Cancer-related Molecular Pathways
- Pelvic floor disorders treatments
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Microtubule and mitosis dynamics
- Spine and Intervertebral Disc Pathology
- Orthopaedic implants and arthroplasty
- Eosinophilic Disorders and Syndromes
- Graphene and Nanomaterials Applications
Renmin Hospital of Wuhan University
2015-2023
Wuhan University
2015-2023
Yonsei University College of Dentistry
2020
Yonsei University
2020
Zhongnan Hospital of Wuhan University
2015
Affiliated Hospital of Chengde Medical College
2014
Juntendo University
2009-2011
University of Calgary
1992
Foothills Medical Centre
1992
Periosteum provides nourishment to bones and facilitates osteogenesis. The structural functional impairment of periosteum can cause bone regeneration difficulties. Artificial with suitable mechanical properties chemical composition effectively guide tissue regeneration. In this study, a polycaprolactone (PCL)/carboxymethyl chitosan (CMCS)/sodium alginate (SA) micron-fibrous bionic was prepared. water-in-oil PCL-CMCS/SA emulsion prepared by using Span 80 as the emulsifier, PCL/CMCS/SA...
Abstract The collagen architecture in normal, aging, and osteoarthritic articular cartilage was studied optically using a new silver staining technique based on specimens from 50 autopsy cases, four amputated limbs, six knees. In the normal cartilage, fibrils superficial zone were compactly arranged into layers of decussating flat ribbons mostly parallel to artificial split lines. showed tendency condense vertical arcade columns undergirded by tangential bundles intermediate zone. deep zone,...
The effects of the transplanted bone morphogenetic protein-2 (BMP2) -related peptide P24 and rhBMP2 combined with poly(lactic-co-glycolic acid) (PLGA)/chitosan (CS) microspheres were investigated in promoting repair rat cranial defect. Forty white rats selected equally divided into four groups (group A: 1 μg rhBMP2/PLGA/CS composite; group B: 3 mg P24/PLGA/CS C: 0.5 + 1.5 D: blank PLGA/CS material), defect models a diameter 5 mm established. materials to defects. animals sacrificed on weeks...
Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women. Weakening pelvic ligaments plays an essential role in pathophysiology POP. Currently, synthetic materials are widely applied for reconstructive surgery. However, nondegradable meshes POP therapy cannot meet clinical requirements due to its poor biocompatibility. Herein, we fabricated electrospun core–shell nanofibers poly(l-lactic acid)-hyaluronic acid (PLLA/HA). After that, combined them...
Fatty acid ethyl esters (FAEEs), non-oxidative metabolites of ethanol, are the main causative agents severe acute pancreatitis resulting from alcohol abuse. Pancreatic acinar cells exposed to ethanol in combination with fatty palmitoleic (EtOH/POA) display increased levels ester and cell death. Oxidative stress necroptosis implicated pathology pancreatitis. Docosahexaenoic (DHA) serves as a powerful anti-oxidant that reduces pancreatic inflammation improves outcomes patients We investigated...
Mitochondria are cytosolic organelles essential for cellular function and survival. The of mitochondria is maintained by mitochondrial quality control systems including fission fusion to adapt the altered environment mitophagy removal damaged mitochondria. Mitochondrial dysfunction closely involved in aging-related diseases. Intervertebral disc (IVD) degeneration, an aging-associated process, major contributor low back pain. Growing evidence has suggested that IVD cells severely compromised...
AbstractThe aim of this work was to develop a bioactive glass/hydroxylapatite/chitason composite material for bone repair. Different proportions mixture make into scaffolds by the freeze-drying method. The microstructure and composition were observed analysed. third-generation rabbit mesenchymal stem cells inoculated stent. adhesion stent detected, proliferation on detected. compatibility between evaluated. size shapes prepared consistent with moulds. has parous structure no aggregation...
Objective To investigate the differentiation potential of rat bone marrow mesenchymal stem cells in dedifferentiation process. Methods Bone (BMSCs) Sprague Dawley rats were isolated and cultured using a whole adherent method. BMSCs induced to dedifferentiate with culture medium containing growth factor (GDF-5), then its tendon was further GDF-5. After 3 weeks, expression type Ⅰ (Col Ⅰ), Collagen Ⅲ (ColⅢ), tenascin-C (TNC), basic Helix-Loop-Helix (scleraxis, SCX) Tenomodulinwas...
Increased proliferation of vascular smooth muscle cells (VSMCs) contributes to the pathogenesis atherosclerosis (AS), and insulin like growth factor 2 (IGF2) is involved in AS through effects on VSMCs migration. The IGF2 mRNA-binding protein 1(IGF2BP1) a secreted that can bind regulate its localization, however, whether IGF2BP1 could remains be elucidated. This study aimed investigate role uncover potential mechanism. Primary human aortic transfected with or without shRNA-IGF2BP1 were...