A5101725538- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Gastrointestinal motility and disorders
- Colorectal and Anal Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Hernia repair and management
- Cancer Immunotherapy and Biomarkers
- Urinary Bladder and Prostate Research
- Ferroptosis and cancer prognosis
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Rheumatoid Arthritis Research and Therapies
- MicroRNA in disease regulation
- Autoimmune and Inflammatory Disorders Research
- Therapeutic Uses of Natural Elements
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Respiratory Support and Mechanisms
- Phytochemical compounds biological activities
- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- Cancer Treatment and Pharmacology
- Hemostasis and retained surgical items
Sun Yat-sen University
2015-2024
Sixth Affiliated Hospital of Sun Yat-sen University
2015-2024
Southwest University of Science and Technology
2022
Key Laboratory of Guangdong Province
2018-2022
Pudong New Area People's Hospital
2018
Neoadjuvant chemotherapy (NAC) for rectal cancer (RC) shows promising clinical response. The modulation of the tumor microenvironment (TME) by NAC and its association with therapeutic response remain unclear. Here, we use single-cell RNA sequencing spatial transcriptome to examine cell dynamics in 29 patients RC, who are sampled pairwise before after treatment. We construct a high-resolution cellular dynamic landscape remodeled their associations markedly reshapes populations...
Abstract Gut microbiota and short‐chain fatty acids (SCFAs) are associated with the development of various human diseases. In this study, we examined role astragaloside IV in modulating mouse gut structure generation SCFAs, as well slow transit constipation (STC). An STC model was established by treating mice loperamide, which therapeutic effects were evaluated. The community SCFA content analysed 16S rRNA gene sequencing gas chromatography‐mass spectrometry, respectively. influence butyrate...
5-fluorouracil (5-FU)-based chemotherapy is the main chemotherapeutic approach for colorectal cancer (CRC) treatment. Because chemoresistance occurs frequently and significantly limits CRC therapies, a novel agent needed. Pseudolaric acid B (PAB), small molecule derived from Chinese medicinal herb ''Tujinpi'', exhibits strong cytotoxic effects on variety of cancers. However, detailed mechanisms by which PAB inhibits cell growth its potential role in overcoming 5-FU resistance have not been...
Abstract Background Neoadjuvant radiation has been increasingly associated with postoperative bowel dysfunction, including low anterior resection syndrome (LARS). Although permanent stoma often results from severe dysfunction and significantly impacts quality of life, the presence paradoxically excludes patients functional follow-up. Hence, status is rarely reported along LARS, while assessment both essential for comprehensive evaluation in long-term survivors rectal cancer. Method Patients...
The cellular characteristics of intestinal cells involved in the therapeutic effects astragaloside IV (AS-IV) for treating slow transit constipation (STC) remain unclear. This study aimed to determine dynamics colon tissue STC model and investigate AS-IV treatment by single-cell RNA sequencing (scRNA-seq). mouse models were developed using loperamide, with subsequent AS-IV. Colon tissues feces collected scRNA-seq targeted short-chain fatty acid quantification. We integrated data network...
Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women. Weakening pelvic ligaments plays an essential role in pathophysiology POP. Currently, synthetic materials are widely applied for reconstructive surgery. However, nondegradable meshes POP therapy cannot meet clinical requirements due to its poor biocompatibility. Herein, we fabricated electrospun core–shell nanofibers poly(l-lactic acid)-hyaluronic acid (PLLA/HA). After that, combined them...
We describe a technique for the management of prolapsing hemorrhoids, with aim to minimize risk anal stricture and rectovaginal fistula reduce impact stapling on rectal compliance. This modified procedure was successfully applied in China, preliminary data showed promising outcomes (see Video, Supplemental Digital Content 1, https://links.lww.com/DCR/A117).
External rectal prolapse is a relatively rare disease, in which male patients account for minority. The selection of abdominal repair or perineal has rarely been investigated.Fifty-one receiving (laparoscopic ventral rectopexy) (Delorme Altemeier procedures) at the Sixth Affiliated Hospital Sun Yat-sen University (Guangzhou, China) between March 2013 and September 2019 were retrospectively analysed. We compared recurrence, complication rate, post-operative defecation disorder, length stay,...
The thermal comfort of preschool children was assumed to be similar that young adults, which may cause inaccuracy. This study tested and analyzed the response characteristics adults (4–6 years old) differences in sensation physiology between two groups participants a room with radiant floor heating system using difference analysis methods (the paired data t-test, Mann–Whitney U test Kruskal–Wallis H test). Participants were divided into groups, preschoolers, sat each condition while wearing...
Background: Endplate inflammation remains a difficult disease to treat, in part due its unclear pathology. Previous experiments showed that patients with idiopathic presented systemic upregulation of Th17 cells. Here, we investigated how this change might affect the inflammatory environment endplate inflammation.Methods: Peripheral blood was obtained from and healthy controls, cells were examined.Results: significantly increased differentiation CD11c+ DC-SIGN+ dendritic (DCs) circulating...
Fournier's gangrene (FG) is a fulminant infection in the external genital region and perineum. The present study explored clinical features of FG originating from anorectal region, primary conditions such as anal fistulas abscesses. A retrospective analysis was performed order to identify factors associated with outcomes patients derived two hospitals-the Sixth Affiliated Hospital Sun Yat-sen University People's Fujian Traditional Chinese-over period May 2013 April 2017. Sixty were included...
This study is designed to assess the safety, efficacy, and postoperative outcomes of stapled transperineal repair in management rectovaginal fistula (RVF).A prospective database patients with RVF undergoing between May 2015 December 2017 was established studied retrospectively.Seven consecutive underwent repair. The mean operative time 119 ± 42 minutes. estimated blood loss during operation 24 14 mL. Concomitant levatorplasty performed 4 sphincteroplasty 2 patients. Over a median follow-up 6...
This study was designed to assess the safety, efficacy, and postoperative outcomes of modified Stapled TransAnal Rectal Resection (modified STARR) in patients presenting with cases limited external rectal prolapse. A prospective cohort mild prolapse undergoing resection Tissue-Selecting Technique Plus (TSTStarr Plus) stapler between February 2014 September 2016 reviewed retrospectively. Twenty-five eligible underwent TSTStarr stapler. The median vertical height resected specimen 5.0 cm...
Currently, rectovaginal fistula (RVF) continues to be a surgical challenge worldwide, with relatively low healing rate. Unclosed intermittent suture and poor materials may the main reasons for this.
Background The relationship between hemorrhoid recurrence and poor defecation habits is poorly understood. This study aimed to analyze the effects of on postoperative recurrence. Materials Method We performed a retrospective 1,162 consecutive patients who underwent surgical procedure for hemorrhoids at Sixth Affiliated Hospital Sun Yat-Sen University from December 2016 May 2020. All were followed 12 months post-operatively. Patients monitored disease Patient assessed using an obstructive...
Abstract Background Accumulating researchers have recognized mitophagy as a key player in tumors, but few studies investigated its role the tumor microenvironment (TME). Advances technology of single-cell RNA sequencing (scRNA-seq) allowed unveiling concealed features TME at cellular resolution. This study aimed to elucidate within colorectal cancer (CRC) and establish mitophagy-mediated risk model. Methods We assessed mitophagy-related pathway activities both tissue levels. Subsequently, an...
The present study was designed to evaluate the functional outcome of stapled transanal rectal resection (STARR) and examine relationship between population density interstitial cells Cajal (ICC) efficacy STARR operation in management obstructed defecation syndrome (ODS) patients. Full-thickness samples were obtained from 50 ODS patients who underwent STARR. Samples analysed using ICC immunohistochemistry. Clinical parameters with defecography anorectal manometry compared 20 controls. ICCs...
As an innovative treatment, stapled transperineal rectovaginal fistula repair (STR) for (RVF) has demonstrated effectiveness in preliminary reports. This study aims to compare STR with rectal mucosal advancement flap (RAF), a widely utilized surgical procedure, the outcome of low- and mid-level RVF. In this retrospective cohort study, patients RVF who underwent or RAF were included from both Sixth Affiliated Hospital Sun Yat-sen University Xi'an Daxing Hospital. Among 99 total patients, 77...