A5100436070- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Effects of Radiation Exposure
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Melanoma and MAPK Pathways
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Molecular Biology Techniques and Applications
- Head and Neck Cancer Studies
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Medical Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
Jining First People's Hospital
2025
Nanjing Drum Tower Hospital
2023
Case Western Reserve University
2023
Tianjin Chest Hospital
2022
Anhui University of Traditional Chinese Medicine
2022
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
Sixth Affiliated Hospital of Sun Yat-sen University
2012-2021
Sun Yat-sen University
2012-2021
BeiGene (China)
2021
Background Programmed death ligand-1 (PD-L1) has been identified as a factor associated with poor prognosis in range of cancers, and was reported to be mainly induced by PTEN loss gliomas. However, the clinical effect PD-L1 its regulation not yet determined colorectal cancer (CRC). In present study, we verified on further correlation between expression parameters CRC. Methods/Results RNA interference approach used down-regulate SW480, SW620 HCT116 cells. It showed that protein, but mRNA,...
Background/Objective Inadvertent intraoperative hypothermia (core temperature <360 C) is a recognized risk in surgery and has adverse consequences. However, no data about this complication China are available. Our study aimed to determine the incidence of inadvertent its associated factors sample Chinese patients. Methods We conducted regional cross-sectional survey Beijing from August through December, 2013. Eight hundred thirty patients who underwent various operations under general...
Biomarkers for predicting chemotherapy response are important to the treatment of colorectal cancer patients. Cryptochrome 2 (CRY2) is a circadian clock protein involved in cell cycle, but biologic consequences this activity poorly understood. We set up biochemical and biology analyses analyze CRY2 expression chemoresistance. Here, we report that overexpressed chemoresistant samples, overexpression correlated with poor patient survival. Knockdown increased sensitivity oxaliplatin cells. also...
Tripartite motif-containing protein 65 (TRIM65) is an E3 ubiquitin ligase and a critical regulator of variety cellular processes as well tumor progression. Therefore, more substrates must be identified in the physiology or disease context. Here, we found that TRIM65 upregulated associated with poor survival colorectal cancer (CRC). More specifically, high expression CRC metastasis recurrence. Ectopic overexpression cell lines enhanced proliferation, invasion, migration, while knockdown had...
Alcoholic liver disease (ALD) is a major worldwide chronic accompanied by hepatic inflammation, gut leakiness, and abnormal oxidative stress. Our previous study demonstrated substantial hepatoprotective activity of the active Poria cocos polysaccharide (PCP-1C). The present explored whether PCP-1C protects against ALD among results showed that significantly improved alcohol-induced injury decreasing serum biochemical parameters, alleviating steatosis, reducing lipid accumulation caused ALD....
Gene expression profiling provides an opportunity to develop robust prognostic markers of colorectal carcinoma (CRC). However, the have not been applied for clinical decision making. We aimed immunohistochemistry signature using microarray data predicting CRC prognosis.We evaluated 25 gene signatures in independent datasets with prognosis information and constructed a subnetwork high concordance repeatable values. Tumours were examined immunohistochemically network-centric top overlapping...
Abstract PEAK1 is upregulated in multiple human malignancies and has been associated with tumor invasion metastasis, but little known about the role of colorectal cancer (CRC) progression. We investigated expression pattern, function regulatory mechanisms CRC. Here, we found that overexpressed CRC tissues high predicts poor survival colon not rectal cancer. Functionally, silencing inhibits cell proliferation, migration, vitro growth xenografts nude mice. Mechanistic studies revealed induced...
Human replication factor C4 (RFC4) is involved in DNA as a clamp loader and aberrantly regulated across range of cancers. The current study aimed to investigate the function RFC4 colorectal cancer (CRC).
Purpose The KRAS gene frequently mutates in colorectal cancer (CRC). Here we investigated the prognostic and predictive role of mutation patients with stage II or III CRC. Experimental design A consecutive cohort CRC from a single center database was studied. association between status, adjuvant FOLFOX therapy, 3‐year disease‐free survival (3‐y DFS) analyzed. Results Of our 433 patients, 166 (38.3%) exhibited mutation. Among 190 who did not receive those tumors had worse 3‐y DFS (hazard...
Abstract Aquaporin-9 (AQP9) expression is associated with arsenic sensitivity in leukemia cells. However, the role of AQP9 regulating tumor to adjuvant chemotherapy colorectal cancer (CRC) has not been elucidated. In this study, we demonstrated that can serve as an independent predictive marker for CRC. Patients high had higher rate disease-free survival (DFS) than those low expression. Upregulation was enhanced chemosensitivity 5-fluorouracil (5-FU) both vitro and vivo . Overexpression...
Tislelizumab is an anti-programmed cell death protein 1 (anti-PD-1) monoclonal antibody specifically designed to minimize binding Fcγ receptors (FcγR).Here, we present the extended 3-year follow-up of a phase II study tislelizumab in 70 patients with relapsed/refractory classical Hodgkin lymphoma (cHL) who failed or were ineligible for autologous stem transplantation.With median 33.8 months, overall response rate by independent review committee was 87.1%, and complete (CR) 67.1%. Responses...
Kartagener syndrome (KS) is a rare autosomal recessive genetic disease characterized by visceral inversion, sinusitis and bronchiectasis. Small-cell lung cancer, common tumor with poor prognosis, rarely coexists KS. The lack of typical clinical symptoms can lead to missed or incorrect diagnoses, date, only few cases this combination have been reported. current study presents case KS small cell cancer that was promptly diagnosed treated at Jining No. 1 People's Hospital (Jining, China)....
Phosphorylated p38 (p-p38) played a pivotal role in the regulation of disease progression and correlated with tumor prognosis. Here, we characterized prognostic effect p-p38 colorectal cancer (CRC). Three hundred sixteen CRC patients stages I–III were recruited this study. P-p38 expression was semi-quantitatively evaluated using tissue microarrays immunohistochemistry staining. Overall survival (OS), disease-free (DFS), local failure-free (LFFS), distant metastasis-free (DMFS) patient...
Background: High serum levels of alpha-fetoprotein (AFP) are observed in some gastrointestinal cancers. However, primary AFP-producing colorectal cancer (CRC) is extremely rare and causes confusion among clinicians. In this study, we analyzed the clinicopathological features clinical outcomes CRC provide a brief view carcinoma. Patients methods: Twenty patients with were enrolled at Fudan University Shanghai Cancer Center from 2012 to 2015. Clinical information, including AFP CEA levels,...
Background Microsatellite instability (MSI) represents the first pan-cancer biomarker approved to guide immune checkpoint blockade (ICB) treatment. However its widespread testing, especially outside of gastrointestinal cancer, is hampered by tissue availability. Methods An algorithm for detecting MSI from peripheral blood was established and validated using clinical plasma samples. Its value predicting ICB efficacy evaluated among 60 patients with advanced cancer. The landscape in also...
5-fluorouracil (5-FU)-based chemotherapy is the main chemotherapeutic approach for colorectal cancer (CRC) treatment. Because chemoresistance occurs frequently and significantly limits CRC therapies, a novel agent needed. Pseudolaric acid B (PAB), small molecule derived from Chinese medicinal herb ''Tujinpi'', exhibits strong cytotoxic effects on variety of cancers. However, detailed mechanisms by which PAB inhibits cell growth its potential role in overcoming 5-FU resistance have not been...
Abstract Spleen tyrosine kinase (SYK) is a candidate tumor suppressor gene in breast. Loss of SYK expression breast tumors as result DNA hypermethylation promotes cell proliferation and invasion predicts shorter survival cancer patients. We previously reported that, addition to its well-known cytoplasmic localization, the full-length Syk also present nucleus that nuclear translocation rate-limiting step determine function. Here, we show form acts transcription repressor nucleus. Ectopic...
A disintegrin and metalloprotease 8 (ADAM8) has been reported to be associated with various malignancies. However, no studies have examined ADAM8 association in colorectal cancer (CRC). The aim of this study was investigate the expression function CRC. Expression level CRC evaluated by quantitative RT-PCR, western blot immunohistochemical staining analysis. role carcinogenesis vitro assays. correlations between status clinicopathological features including survival were analyzed. highly...
Abstract The nerve growth factor receptor (NGFR/p75) is a potential tumor suppressor, but its role in colorectal cancer unknown. Here, the hypermethylation status, biologic function, and clinical relevance were determined for p75NGFR cancer. methylation status expression of assessed cell lines tissues by bisulfite genomic sequencing (BGS), qRT-PCR, immunoblot assay. Methylation was frequently found cancer, leading to silencing or downregulation, it effectively restored demethylation agent....
The incidence of colorectal cancer (CRC) is increasing in China. Here, we aimed to evaluate the latest demographic trends and KRAS/BRAF mutations status Chinese CRC. Five thousand five hundred forty‐six CRC patients diagnosed from 2010 2017 were involved. KRAS exon 2 BRAF V600E detected by Sanger sequencing high‐resolution melting analysis or allelic‐specific probe method. Gene mutation profiles clinicopathologic characteristics 5495 analyzed. joinpoint regression model was used predict data...
CDK11p58, a Ser/Thr kinase that belongs to the cell division cycle 2-like 1 (CDC2L1) subfamily, is associated with progression, tumorigenesis and apoptotic signaling. CDK11p58 also involved in regulation of steroid receptors, such as androgen estrogen receptors. We previously found was abnormally expressed prostate cancer. However, its role breast cancer remains unclear. expression evaluated by immunohistochemical staining tissue array. A Transwell assay used detect invasion metastasis...