A5073068172- Cardiac Ischemia and Reperfusion
- Sirtuins and Resveratrol in Medicine
- Wound Healing and Treatments
- Nitric Oxide and Endothelin Effects
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Atrial Fibrillation Management and Outcomes
- Tissue Engineering and Regenerative Medicine
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Burn Injury Management and Outcomes
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- Circadian rhythm and melatonin
- Inflammatory mediators and NSAID effects
- Electrospun Nanofibers in Biomedical Applications
- Kruppel-like factors research
- Transplantation: Methods and Outcomes
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Cardiac electrophysiology and arrhythmias
- Garlic and Onion Studies
- Fuel Cells and Related Materials
- CNS Lymphoma Diagnosis and Treatment
General Hospital of Shenyang Military Region
2015-2025
Chinese PLA General Hospital
2021-2024
Fujian Agriculture and Forestry University
2022-2023
Gansu Provincial Hospital
2011-2020
Command Hospital
2019
Shenyang 242 Hospital
2013-2017
Air Force General Hospital PLA
2015
Northern Hospital
2014
Lanzhou University
2011
Abstract Enhancing mitochondrial biogenesis and reducing oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial ischemia/reperfusion (MI/R) injury. Melatonin has been reported be a safe potent cardioprotective agent. However, its role on or reactive oxygen species (ROS) production in type 1 myocardium the underlying mechanisms remain unknown. We hypothesize that melatonin ameliorates MI/R injury rats by preserving function via AMPK-PGC-1α-SIRT3...
Abstract Targeting mitochondrial quality control with melatonin has been found promising for attenuating diabetic cardiomyopathy (DCM), although the underlying mechanisms remain largely undefined. Activation of SIRT6 and membrane receptors exerts cardioprotective effects while little is known about their roles during DCM. Using high‐fat diet‐streptozotocin‐induced rat model, we that prolonged diabetes significantly decreased nocturnal circulatory heart levels, reduced expressions cardiac...
Background/Objective Inadvertent intraoperative hypothermia (core temperature <360 C) is a recognized risk in surgery and has adverse consequences. However, no data about this complication China are available. Our study aimed to determine the incidence of inadvertent its associated factors sample Chinese patients. Methods We conducted regional cross-sectional survey Beijing from August through December, 2013. Eight hundred thirty patients who underwent various operations under general...
Naringenin directly inhibits mitochondrial oxidative stress damage and preserves biogenesis<italic>via</italic>AMPK-SIRT3 signaling, thus attenuating MI/R injury.
The potential coexistence of Alzheimer's disease (AD) and atrial fibrillation (AF) is increasingly common as aging-related diseases. However, little known about mechanisms responsible for remodeling in AD pathogenesis. α7 nicotinic acetylcholine receptors (α7nAChR) has been shown to have profound effects on mitochondrial oxidative stress both organ Here, we investigate the role α7nAChR mediating amyloid-β (Aβ) cultured mouse cardiomyocytes (HL-1 cells) model mice (APP/PS1). In vitro,...
The success rate of catheter ablation in atrial fibrillation (AF) is known to be lower females than males. However, while the exact mechanism for this phenomenon remains elucidated, tissue fibrosis may play an important role regard. It has been shown that promotes AF and its recurrence, thereby substantially reducing efficacy patients. Thus, we hypothesized contribute gender differences outcomes ablation. Here systematically assessed pulmonary vein sleeves obtained from 166 patients with...
Abstract Stress hyperglycemia is commonly observed in patients suffering from ischemic heart disease. It not only worsens cardiovascular prognosis but also attenuates the efficacies of various cardioprotective agents. This study aimed to investigate protective effect melatonin against myocardial ischemia‐reperfusion ( MI /R) injury acute hyperglycemic state with a focus on Notch1/Hes1/Akt signaling and intracellular thioredoxin (Trx) system. Sprague Dawley rats were subjected /R surgery...
Diabetes exacerbates oxidative/nitrative stress during myocardial ischemia‐reperfusion (MI/R) injury. Recent studies highlighted the cardioprotective actions of polydatin. However, its effect on diabetic MI/R injury and underlying mechanisms remain unknown. This work was undertaken to evaluate polydatin with a focus Notch1/Hes1 signaling stress. Streptozotocin‐ (STZ‐) induced rats were administered (20 mg/kg/d) in absence or presence DAPT (a γ ‐secretase inhibitor) LY294002 PI3K/Akt then...
Endoplasmic reticulum (ER) stress and oxidative contribute greatly to myocardial ischemia-reperfusion (MI/R) injury. Naringenin, a flavonoid derived from the citrus genus, exerts cardioprotective effects. However, effects of naringenin on ER as well under MI/R condition detailed mechanisms remain poorly defined. This study investigated protective effect MI/R-injured heart with focus cyclic guanosine monophosphate- (cGMP-) dependent protein kinase (PKG) signaling. Sprague-Dawley rats were...
Abstract Background Diabetes mellitus (DM) exacerbates coronary artery disease (CAD) morbidity and mortality. Mesenchymal stem cells (MSCs) play an important therapeutic role in myocardial ischemic injury. However, little is known about changes the cardioprotective characteristics of MSCs from patients with DM. Methods Sternal bone marrow aspirates were taken at time bypass graft surgery. The morphology growth hMSCs observed passage 3. Differences gene expression profiling measured by...
Diallyl trisulfide (DATS), the major active ingredient in garlic, has been reported to confer cardioprotective effects. However, its effect on myocardial ischemia-reperfusion (MI/R) injury diabetic state and underlying mechanism are still unknown. We hypothesize that DATS reduces MI/R via AMPK-mediated AKT/GSK-3β/HIF-1α activation. Streptozotocin-induced rats received surgery with or without (20mg/kg) treatment presence absence of Compound C (Com.C, an AMPK inhibitor, 0.25mg/kg) LY294002 (a...
Background Circular RNAs (circRNAs) are pervasively expressed in highly divergent eukaryotes and stable body fluids. However, the link between circRNAs onset of atrial fibrillation (AF) has not previously been investigated. We aimed to identify plasma that able predict AF after cardiac surgery. Methods Results Plasma circRNA expression profiles were investigated a total 769 patients with or without isolated off‐pump coronary artery bypass grafting. First, microarray was used screen 13 617...
Polydatin has attracted much attention as a potential cardioprotective agent against ischemic heart disease and diabetic cardiomyopathy. However, the effect mechanism of polydatin supplementation on alcoholic cardiomyopathy (ACM) are still unknown. This study aimed to determine therapeutic ACM explore molecular mechanisms with focus SIRT6-AMP-activated protein kinase (AMPK) signaling mitochondrial function. The model was established by feeding C57/BL6 mice an ethanol Lieber-DeCarli diet for...
Objectives. Low survival rate of mesenchymal stem cells (MSCs) severely limited the therapeutic efficacy cell therapy in treatment myocardial infarction (MI). Bcl-xL genetic modification might enhance MSC after transplantation. Methods. Adult rat bone marrow MSCs were modified with human gene (hBcl-xL-MSCs) or empty vector (vector-MSCs). apoptosis and paracrine secretions characterized using flow cytometry, TUNEL, ELISA vitro . In vivo , randomized adult rats MI received injections one three...
Longan (Dimocarpus longan Lour.) is an economically important subtropical fruit tree. Its quality and yield are affected by embryo development. As a plant seed germination marker gene, the germin-like protein (GLP) gene plays role in However, mechanism underlying of GLP somatic embryos still unclear. Therefore, we conducted genome-wide identification (DlGLP) preliminarily verified function DlGLP1-5-1. Thirty-five genes were identified as divided into 8 subfamilies. Based on transcriptome...
This study aimed to assess the feasibility, safety, and accuracy of a low-dose CT fluoroscopy-guided remote-controlled robotic real-time puncture procedure.