A5100338124- Blood Pressure and Hypertension Studies
- Mesenchymal stem cell research
- Pharmaceutical studies and practices
- Heart Failure Treatment and Management
- Gastrointestinal motility and disorders
- Analytical Methods in Pharmaceuticals
- Pharmacogenetics and Drug Metabolism
- Electrolyte and hormonal disorders
- Antibiotics Pharmacokinetics and Efficacy
- Spectroscopy and Chemometric Analyses
- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- Cardiovascular Health and Risk Factors
- Hormonal Regulation and Hypertension
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- Advanced Chemical Sensor Technologies
- Attention Deficit Hyperactivity Disorder
- Neonatal Health and Biochemistry
- Sexual function and dysfunction studies
- Gout, Hyperuricemia, Uric Acid
- Autoimmune and Inflammatory Disorders Research
- Heart rate and cardiovascular health
- Lung Cancer Research Studies
Guizhou Center for Disease Control and Prevention
2025
Nanjing University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Peking Union Medical College Hospital
2011-2024
Xiamen University
2023-2024
Third Xiangya Hospital
2022-2024
Central South University
2022-2024
Guiyang Medical University
2024
Affiliated Hospital of Guizhou Medical University
2024
Wuhan University
2011-2024
Aflatoxin B1 (AFB1) is an important cause of human liver cancer. This study proposes a quantitative detection method for the AFB1 in corn based on Fourier transform near-infrared (FT-NIR) spectroscopy technology. First, we acquired spectral data samples with different degrees mildew using FT-NIR spectrometer; then, used ant colony optimization (ACO) and NSGA-Ⅱ algorithms to optimize characteristic wavelengths spectra after SNV treatment respectively; Finally, back propagation neural network...
Pharmacokinetics (PK) plays a key role in bridging drug efficacy and safety from adults to pediatric patients. The principal purpose of projecting dosing pediatrics is guide trial design, not waive the study per se. This research was designed evaluate whether allometric scaling (AS) approach satisfactory method design PK studies patients aged 2 years older. We systematically evaluated drugs that had label information updated 1998 2015. Only intravenous (IV) or oral administration with...
Abstract Motivation Many studies have shown that IDH mutation and 1p/19q co-deletion can serve as prognostic signatures of glioma. Although these genetic variations affect the expression one or more genes, value gene related to status is still unclear. Results We constructed an ensemble pair signature for risk evaluation survival prediction glioma based on prior knowledge status. First, we separately built two IDH-GPS 1p/19q-GPS elucidated they were useful transcriptome markers projecting...
Visceral adipose tissue assessment holds significant importance in hypertension prevention. This study aimed to explore the association between Metabolic Score for Fat (METS-VF), a new indicator based on laboratory and anthropometry measures, risk further investigate METS-VF of different ethnic groups. In this study, total 9,280 people from 48 townships 12 districts (counties) Guizhou Province were selected survey using multistage cluster random sampling method, 5,127 cases finally included...
Background: Death in dyslipidemia is a significant health problem, dietary intervention plays an important role this context. Objective: Our study investigated the association between patterns and all-cause mortality individuals with dyslipidemia. This will lay foundation for relevant departments to develop more precise targeted strategies help high-risk people early prevention by adjusting their patterns, which may reduce medical burden. Methods: included 5369 participants. Factor analysis...
A prospective multicenter study was conducted to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of fludarabine plasma (f-ara-a) intracellular triphosphate (f-ara-ATP) in children undergoing hematopoietic cell transplantation (HCT) receiving with conditioning. Plasma peripheral blood mononuclear cells (PBMCs) were collected over course therapy for quantitation f-ara-a f-ara-ATP. Nonlinear mixed-effects modeling used develop PK model, including identification covariates...
Cystic fibrosis (CF), the most common life-threatening autosomal recessive disorder in Caucasians, is caused by mutations CF transmembrane conductance regulator gene (CFTR). We and others previously identified CFTR 20 Chinese patients with CF. In this study, eight a clinical diagnosis of suspected were newly collected screened for using combination conventional Sanger sequencing multiplex ligation-dependent probe amplification (MLPA) analysis. The observed patients, both reported present...
On 16 December 2020, FDA approved Benlysta® (belimumab) for both the intravenous (IV) and subcutaneous (SC) administration routes treatment of adult patients with active lupus nephritis (LN) who are receiving standard therapy. This approval represents first LN.The IV dosing regimen (10 mg/kg dose Q2W three doses, then 10 Q4W thereafter) was based on a randomized double-blind placebo controlled clinical trial in LN. For SC (400 mg QW four 200 thereafter), efficacy supported solely by...
Conducting and analyzing clinical trials in vulnerable neonates are extremely challenging. The aim of this analysis is to develop a morphine population pharmacokinetics (PK) model using data collected during randomized control trial with abstinence syndrome (NAS). A 3-compartment structural PK after intravenous (IV) administration from previously published work was utilized as prior, whereas an allometric scaling method physiological consideration used extrapolate profile adults pediatrics....
Pancreatic cancer (PC) is a devastating malignancy with an extremely high mortality rate and poses significant challenges to healthcare systems worldwide. The prevalence of PC risk factors spiked over the years, leading global increase in incidence rates. contribution different factors, however, varied from region due genetic predisposition, environmental, social, political underlying disease addition public health strategies. This comprehensive review aims provide thorough analysis...
Objectives. Low survival rate of mesenchymal stem cells (MSCs) severely limited the therapeutic efficacy cell therapy in treatment myocardial infarction (MI). Bcl-xL genetic modification might enhance MSC after transplantation. Methods. Adult rat bone marrow MSCs were modified with human gene (hBcl-xL-MSCs) or empty vector (vector-MSCs). apoptosis and paracrine secretions characterized using flow cytometry, TUNEL, ELISA vitro . In vivo , randomized adult rats MI received injections one three...
To assess the efficacy and safety of intravenous (IV) chlorothiazide versus oral metolazone when added to loop diuretics in patients with acute decompensated heart failure (ADHF) diuretic resistance.Retrospective cohort study.Large urban academic medical center.Adults admitted ADHF between 2005 2015 who had resistance, defined as administration IV furosemide at a dose 160 mg/day or higher (or an equivalent bumetanide), during hospitalization, then received least one (88 patients) (89 augment...
Some observations have suggested that extensive culture of adult stem cells can lead to malignant transformation. Therefore, it has become commonplace use undergoing little or no in vitro circumvent this presumptive limitation. Recently, a detailed study documented transformation neural be avoided under suitable conditions. Here, we report the first demonstration murine bone marrow-derived mesenchymal (bMSCs) were propagated for up 50 passages without any sign However, must noted although...
Recent studies have suggested that adipose tissue-derived mesenchymal stem cell (ADSC) therapy and OX40 costimulation blockade are two immunomodulatory strategies used to suppress the immune response alloantigens. However, relatively little has been reported regarding potential of abilityof these synergize. Thus, in present study, we aimed investigate OX40-Ig fusion protein (OX40Ig) expression ADSCs validate their more potent immunosuppressive activity preventing renal allograft rejection....
Compared with the standard of care sunitinib, avelumab plus axitinib can increase progression-free survival in first-line advanced renal cell carcinoma (RCC), but economic effect treatment is unknown. The purpose research was to evaluate cost-effectiveness versus sunitinib for RCC from US payer perspective.A Markov model developed and health outcomes vs setting RCC. clinical data were obtained JAVELIN Renal 101 Clinical Trials. Deterministic probabilistic sensitivity analyses performed...
Ischemia-reperfusion injury (IRI) is an inevitable complication of liver surgery and transplantation. Hepatocyte apoptosis plays a significant role in the pathological process hepatic IRI. Adipose-derived stem cells (ADSCs) are known to repair regenerate damaged tissues by producing bioactive factors, including cytokines, exosomes, extracellular matrix components, which collectively form secretome these cells. The aim this study was assess protective effects ADSCs after ischemia-reperfusion...
The US Food and Drug Administration (FDA) has concluded that the efficacy of drugs approved for treatment partial onset seizures (POS) in adults can be extrapolated to pediatric patients 1 month age above independent trials this population are no longer needed. This paper focuses on dosing, pharmacokinetic (PK), exposure-response, clinical information were leveraged from POS conduct analyses supported extrapolation patients. Clinical data eight (levetiracetam, oxcarbazepine, topiramate,...
Chloramphenicol (CAP), an antimicrobial drug that is widely used in animal feed, would have a negative effect on human health due to its low elimination rate and relatively high residue food. It important develop rapid economic method determine CAP food ensure not affected.A new fluorescence immunochromatography strip was developed established for the detection of chicken muscles first time. A CAP-bovine serum albumin conjugate, monoclonal antibody polyclonal against were applied constitute...