A5015353795- Pharmaceutical studies and practices
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- BRCA gene mutations in cancer
- Childhood Cancer Survivors' Quality of Life
- Infant Development and Preterm Care
- Pediatric Pain Management Techniques
- Pharmacogenetics and Drug Metabolism
- Prenatal Substance Exposure Effects
- Anesthesia and Sedative Agents
- Neonatal Health and Biochemistry
- Cardiovascular Conditions and Treatments
- Genomics and Rare Diseases
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Antibiotics Pharmacokinetics and Efficacy
- Retinopathy of Prematurity Studies
- Anesthesia and Neurotoxicity Research
- Infant Nutrition and Health
- Health Systems, Economic Evaluations, Quality of Life
- Cannabis and Cannabinoid Research
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
Hospital for Sick Children
2022-2025
University of Toronto
2022-2025
Children's Mercy Hospital
2015-2024
University College London
2024
SickKids Foundation
2022-2024
Great Ormond Street Hospital
2024
Royal Devon & Exeter NHS Foundation Trust
2024
University of Missouri–Kansas City
2017-2023
University of Missouri
2021
Johns Hopkins University
2012-2019
To determine if oral clonidine would reduce the duration of opioid detoxification for neonatal abstinence syndrome.Infants with intrauterine exposure to methadone or heroin and syndrome (2 consecutive modified Finnegan scores > =9) were enrolled at 2 hospitals during 2002-2005 followed until final hospital discharge. All infants (80) received diluted tincture opium according a standardized algorithm randomly assigned receive (1 microg/kg every 4 hours) (40 infants) placebo infants). Primary...
Abstract Background Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder which can respond to proton-pump inhibitors (PPIs). Genetic variation in the CYP2C19 metabolism gene influences PPI efficacy and adverse effects. Pharmacogenetic testing (PGx) predict response by analyzing genetic variation, particularly identifying patients categorized as rapid or ultra-rapid metabolizers who might benefit from dosage increases changes pharmacotherapy. Although PGx clinical practice...
Abstract Human milk is essential for infant nutrition and immunity, providing protection against infections other immune-mediated diseases during the lactation period beyond in later childhood. Milk contains a broad range of bioactive factors such as nutrients, hormones, enzymes, immunoglobulins, growth factors, cytokines, antimicrobial well heterogeneous populations maternal cells. The soluble cellular components are dynamic over time to meet needs growing infant. In this study, we utilize...
Conducting and analyzing clinical trials in vulnerable neonates are extremely challenging. The aim of this analysis is to develop a morphine population pharmacokinetics (PK) model using data collected during randomized control trial with abstinence syndrome (NAS). A 3-compartment structural PK after intravenous (IV) administration from previously published work was utilized as prior, whereas an allometric scaling method physiological consideration used extrapolate profile adults pediatrics....
Abstract Commercial pharmacogenetic testing panels capture a fraction of the genetic variation underlying medication metabolism and predisposition to adverse reactions. In this study we compared in six pharmacogenes detected by whole genome sequencing (WGS) targeted commercial panel cohort 308 individuals with family history pediatric heart disease. 1% cohort, WGS identified rare variants that altered interpretation metabolizer status would thus prevent potential errors gene-based dosing.
Although neonates and young infants with cholestasis are commonly treated either phenobarbital or ursodeoxycholic acid (ursodiol), there is no evidence that effective for this indication. Our objective was to compare the effectiveness of ursodiol treatment in a diverse NICU population.This retrospective cohort study including who were admitted Level IV between January 2010 December 2015. Drug courses identified within medical record, medical, demographic, drug information extracted. The...
Anti-vascular endothelial growth factor (VEGF) therapy for retinopathy of prematurity (ROP) has potential ocular and systemic advantages compared with laser, but we believe the risks anti-VEGF in preterm infants are poorly quantified.To determine whether there was an association increased risk pulmonary hypertension (PH) ROP following treatment as laser treatment.This multicenter retrospective cohort study took place at neonatal intensive care units 48 children's hospitals US Pediatric...
Abstract Objective To determine the association of timing steroid therapy for bronchopulmonary dysplasia (BPD) and outcomes. Methods Retrospective cohort study preterm infants treated with low‐dose dexamethasone BPD. Infants steroids at day life (DOL) 14‐28 (moderately late group) were compared to DOL 29‐42 (delayed group). Inverse probability treatment weighting (IPTW) adjusted propensity scores used correct potential confounders. The primary outcome interest was postmenstrual age (PMA)...
Objective: Neonatal intensive care unit (ICU) involves use of opiates to treat postoperative, ventilated, or chronically ill infants. Opiates provide necessary analgesia and sedation, but the morbidities include prolonged neonatal abstinence syndrome (NAS) extended length stay for dose tapering. Our objective was quantify trends in opiate exposure a tertiary NICU. The authors hypothesize that medical resultant ICU-acquired NAS would increase over time.Design: Retrospective cross-sectional...
A prospective cohort study was performed in preterm infants less than 32 weeks gestation at birth who were treated with dexamethasone for developing or established bronchopulmonary dysplasia (BPD). Respiratory phenotype (Respiratory Severity Score (RSS)), serum, and urine metabolomics assessed before after treatment. Ten provided nine matched serum samples. There a significant decrease RSS steroid Serum gluconic acid had the largest median fold change (140 times decreased, P = 0.008). In...
Abstract Objective To evaluate the association between time of first systemic corticosteroid initiation and bronchopulmonary dysplasia (BPD) in preterm infants. Study design A multi‐center retrospective cohort study from January 2010 to December 2016 using Children's Hospitals Neonatal Database Pediatric Health Information System database was conducted. The population included infants <32 weeks' gestation treated with corticosteroids after 7 days age before 34 postmenstrual age. Stepwise...