A5100387880- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Renal and Vascular Pathologies
- Genetic Syndromes and Imprinting
- Infective Endocarditis Diagnosis and Management
- Genetic and Kidney Cyst Diseases
- Peripheral Artery Disease Management
- Lysosomal Storage Disorders Research
- Coronary Interventions and Diagnostics
- MRI in cancer diagnosis
- Cardiovascular Disease and Adiposity
- Cardiovascular Issues in Pregnancy
- Cerebrovascular and Carotid Artery Diseases
- Dialysis and Renal Disease Management
- Cardiovascular Effects of Exercise
- Sports Performance and Training
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Cardiomyopathy and Myosin Studies
- Trypanosoma species research and implications
- Mechanical Circulatory Support Devices
Southern Medical University
2024
Manchester University NHS Foundation Trust
2024
Zhujiang Hospital
2021-2024
Yueyang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
University of Birmingham
2016-2023
University Hospitals Birmingham NHS Foundation Trust
2016-2023
Soochow University
2023
Harbin Institute of Technology
2023
NIHR Surgical Reconstruction and Microbiology Research Centre
2020-2023
Abnormalities in cardiac structure and function are common patients hospitalized with severe COVID-19 pneumonia who have evidence of myocardial injury based on elevated high-sensitivity troponin (HScTn).1Kim J. Volodarskiy A. Sultana R. Pollie M.P. Yum B. Nambiar L. et al.Prognostic utility right ventricular remodeling over conventional risk stratification COVID-19.J Am Coll Cardiol. 2020; 76: 1965-1977Crossref PubMed Scopus (79) Google Scholar Studies performing transthoracic...
Acute kidney injury is a common and severe complication of sepsis. Sepsis -induced acute injury(S-AKI) an independent risk factor for mortality among sepsis patients. However, the mechanisms S-AKI are complex poorly understand. Therefore, exploring underlying may lead to development therapeutic targets.A model was established in male C57BL/6 mice using cecal ligation puncture (CLP). The data-independent acquisition (DIA)-mass spectrometry-based proteomics used explore protein expression...
O
Myocardial deformation is a sensitive marker of sub-clinical myocardial dysfunction that carries independent prognostic significance across broad range cardiovascular diseases. It now possible to perform 3D feature tracking SSFP cines on cardiac magnetic resonance imaging (FT-CMR). This study provides reference ranges for FT-CMR and assesses its reproducibility compared 2D FT-CMR. One hundred healthy individuals with 10 men women in each 5 age deciles from 20 70 years, underwent left...
Introduction Detecting early cardiac involvement in Fabry disease (FD) is important because therapy may alter progression. Cardiovascular magnetic resonance (CMR) can detect T1 lowering, representing myocardial sphingolipid storage. In many diseases, mechanical dysfunction be detected by abnormal global longitudinal strain (GLS). We explored the relationship of and deposition FD. Methods An observational study 221 FD 77 healthy volunteers (HVs) who underwent CMR (LV volumes, mass, native T1,...
BackgroundReproducible and repeatable assessment of right heart function is vital for monitoring congenital acquired disease. There increasing evidence the additional value myocardial deformation (strain strain rate) in determining prognosis. This study aims to determine reproducibility analyses using cardiovascular magnetic resonance feature tracking (FT-CMR); establish normal ranges within an adult population.MethodsA cohort 100 healthy subjects containing 10 males females from each decade...
Background Neuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function ‘vesicle’ about connectivity were identified, synaptosomal-associated 25 (SNAP25), one of those proteins, was found to have discrepant expression levels neuropathies. However, specific mechanism prognostic value SNAP25 during glioma remain...
During the period spanning November 2013 to 2018, 294 outbreak cases of PPR were diagnosed. Spatio-temporal cluster analysis was performed determine whether or not areas and time periods with significant aggregation outbreaks occurred. High-risk for in China detected using presence-only maximum entropy ecological niche model. The identified three statistically disease clusters. Precipitation driest month as most important predictor PPRV occurrence.
The study aim was to comprehensively assess physiological function and muscle morphology in chronically trained older individuals against untrained young individuals. In a cross-sectional design, 15 controls (YC) (20 ± 2.7 years, 78.9 13.3 kg), 12 (OC) (69.8 4.1 77.5 14.2 14 endurance-trained master athletes (MA) (67.1 68.7 6.5 kg) underwent assessments of body composition, aerobic capacity, strength, architecture, fiber-type morphology. Skeletal index lower fat greater OC versus MA....
Introduction The echocardiographic measurement of left ventricular ejection fraction (LVEF) is fundamental to the diagnosis and classification patients with heart failure (HF). Methods This paper aimed quantify LVEF automatically accurately proposed pipeline method based on deep neural networks ensemble learning. Within pipeline, an Atrous Convolutional Neural Network (ACNN) was first trained segment ventricle (LV), before employing area-length formulation ellipsoid single-plane model...
Patients with chronic kidney disease (CKD) have a disproportionately high risk of cardiovascular (CV) morbidity and mortality from the very early stages CKD. This excess is believed to be result myocardial commonly termed uremic cardiomyopathy (UC). It has been suggested that interstitial fibrosis progresses advancing may key mediator UC. longitudinal study reports data on structure function 30 patients CKD no known healthy controls. All underwent cardiac magnetic resonance imaging including...
Increased native myocardial T1 times in chronic kidney disease (CKD) may be due to diffuse interstitial fibrosis (DIF) or edema/inflammation. Concerns relating nephrogenic systemic with gadolinium-based contrast agents (GBCA) limit their use end-stage (ESKD) measure extracellular volume (ECV) and characterise fibrosis. This study aimed examine stability of T2 before, within 2 months after transplantation; a time frame when status normalises but remodelling is unlikely have occurred, compare...
Ischemia-reperfusion injury (IRI) is an inevitable complication of liver surgery and transplantation. Hepatocyte apoptosis plays a significant role in the pathological process hepatic IRI. Adipose-derived stem cells (ADSCs) are known to repair regenerate damaged tissues by producing bioactive factors, including cytokines, exosomes, extracellular matrix components, which collectively form secretome these cells. The aim this study was assess protective effects ADSCs after ischemia-reperfusion...
Myocardial fibrosis occurs in end-stage heart failure secondary to mitral regurgitation (MR), but it is not known whether this present before onset of symptoms or myocardial dysfunction. This study aimed characterise chronic severe primary MR on histology, compare tissue characterisation cardiovascular magnetic resonance (CMR) imaging, and investigate associations with symptoms, left ventricular (LV) function, exercise capacity. Patients class I IIa indications for surgery underwent CMR...
[Figure: see text].
Diabetic nephropathy (DN) is a common complication of type 2 diabetes mellitus (T2DM) that significantly impacts the quality life for affected patients. Dyslipidemia known risk factor developing cardiovascular complications in T2DM However, association between serum lipoprotein(a) (Lp(a)) and high-density lipoprotein cholesterol (HDL-C) with DN requires further investigation.For this cross-sectional study, we randomly selected patients (DN, n = 211) without (T2DM, 217) from cohort 142,611...