A5074265414- Cardiovascular Function and Risk Factors
- Renal and Vascular Pathologies
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Organ Donation and Transplantation
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Potassium and Related Disorders
- Genetic Syndromes and Imprinting
- Heart Failure Treatment and Management
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Lysosomal Storage Disorders Research
- Cardiac Valve Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Chronic Kidney Disease and Diabetes
- Transplantation: Methods and Outcomes
- Nephrotoxicity and Medicinal Plants
- Acute Kidney Injury Research
- Cytomegalovirus and herpesvirus research
- Cardiovascular Health and Disease Prevention
- Genomics and Chromatin Dynamics
- Healthcare Systems and Public Health
University of Birmingham
2017-2024
Queen Elizabeth Hospital Birmingham
2017-2023
Queen Elizabeth Hospital
2021
University Hospitals Birmingham NHS Foundation Trust
2017-2021
NIHR Surgical Reconstruction and Microbiology Research Centre
2021
Renal Association
2020
National Health Service
2020
Auckland City Hospital
2020
Queen Elizabeth Hospital
2018
John Hunter Hospital
1994-2017
Myocardial deformation is a sensitive marker of sub-clinical myocardial dysfunction that carries independent prognostic significance across broad range cardiovascular diseases. It now possible to perform 3D feature tracking SSFP cines on cardiac magnetic resonance imaging (FT-CMR). This study provides reference ranges for FT-CMR and assesses its reproducibility compared 2D FT-CMR. One hundred healthy individuals with 10 men women in each 5 age deciles from 20 70 years, underwent left...
ABSTRACT The wide overlap between the syndromes of chronic kidney disease (CKD) and heart failure (HF) means that familiarity with 2021 European Society Cardiology guidelines is importance to nephrologists. common risk factors for two together adverse cardiac structural remodelling associated CKD many patients experience breathlessness fall within HF phenotypes categorized in guidelines. management evolving rapidly leading significant changes latest guideline iteration. have changed from...
Abstract We obtain gas viscosities with a pressure-based mass-flow controller used for semi-conductor manufacturing, rate-of-change approach, and physics-based calculation. The novelty of this method is that it in an industrial process whose main goal not to measure viscosities. In way, pressures the order 10 kPa 25 ∘ C 35 C, we seven gases mean absolute errors respect reference less than 1%. Using method, report two semiconductor-manufacturing available open literature: hexafluoroisobutene...
Patients with chronic kidney disease (CKD) have a disproportionately high risk of cardiovascular (CV) morbidity and mortality from the very early stages CKD. This excess is believed to be result myocardial commonly termed uremic cardiomyopathy (UC). It has been suggested that interstitial fibrosis progresses advancing may key mediator UC. longitudinal study reports data on structure function 30 patients CKD no known healthy controls. All underwent cardiac magnetic resonance imaging including...
Alström syndrome (AS) is a rare autosomal recessive ciliopathy with wide spectrum of clinical features, including cone-rod retinal dystrophy, neuronal deafness, severe insulin resistance and major organ failure. The characteristics renal disease in the have not been systematically described. aim this study to define onset progression AS.Prospective observational cohort study.Thirty-two adult subjects from national specialist clinic UK 86 an international AS registry were studied.First,...
Increased native myocardial T1 times in chronic kidney disease (CKD) may be due to diffuse interstitial fibrosis (DIF) or edema/inflammation. Concerns relating nephrogenic systemic with gadolinium-based contrast agents (GBCA) limit their use end-stage (ESKD) measure extracellular volume (ECV) and characterise fibrosis. This study aimed examine stability of T2 before, within 2 months after transplantation; a time frame when status normalises but remodelling is unlikely have occurred, compare...
AP-2α is a transcription factor implicated in the regulation of differentiation and proliferation certain tissues, including mammary gland. In breast tumours, continued expression has been correlated with better prognosis, but this hard to reconcile reported role upregulation ERBB2 oncogene. The existence TFAP2A isoforms, deriving from alternative first exons differing their N-terminal sequence, described some mammals, relative abundance activity not investigated human breast.Expression...
Summary: A 63-year-old woman presented with signs and symptoms of an estrogen-producing ovarian tumor. At laparotomy, this tumor proved to be a multilocular right mass 20 cm in greatest diameter. The cystic spaces were lined by typical benign mucinous epithelium the endocervical type, while greatly thickened cyst walls contained diffuse proliferation granulosa cells. These two disparate components intimately mixed at variably complex interface form composite While tumors showing sex...
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Background and objectives The Effect of a Reduction in GFR after Nephrectomy on Arterial Stiffness Central Hemodynamics (EARNEST) study was multicenter, prospective, controlled designed to investigate the associations an isolated reduction kidney function BP arterial hemodynamics. Design, setting, participants, & measurements Prospective living donors healthy controls who fulfilled criteria for donation were recruited from centers with expertise vascular research. Participants underwent...
ABSTRACT Background Fabry disease (FD) is an X-linked lysosomal storage disorder caused by α-galactosidase A (α-Gal A) deficiency, resulting in multi-organ accumulation of sphingolipid, namely globotriaosylceramide (Gb3). This triggers ventricular myocardial hypertrophy, fibrosis, and inflammation, driving arrhythmia sudden death, a common cause FD mortality. Atrial fibrillation (AF) FD, yet the cellular mechanisms accounting for this are unknown. To address this, we conducted...
Chronic kidney disease (CKD) is associated with increased left ventricular (LV) mass and arterial stiffness. In a previous trial, spironolactone improved these end points compared placebo in subjects early-stage CKD, but it not known whether effects were specific to the drug or secondary blood pressure lowering. The aim was investigate hypothesis that superior chlorthalidone reduction of LV while exerting similar on pressure. This multicenter, prospective, randomized, open-label, blinded...
Abstract Background Late gadolinium enhancement (LGE) using cardiac magnetic resonance (CMR) characterizes myocardial disease and predicts an adverse cardiovascular (CV) prognosis. Myocardial abnormalities, are present in early chronic kidney (CKD). To date there no data defining prevalence, pattern clinical implications of LGE-CMR CKD. Methods Patients with pre-dialysis CKD (stage 2–5) attending specialist renal clinics at University Hospital Birmingham (UK) who underwent enhanced CMR (1.5...