A5047079864- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Stroke Rehabilitation and Recovery
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Physical Activity and Health
- Frailty in Older Adults
- Balance, Gait, and Falls Prevention
- Acute Ischemic Stroke Management
- Cardiovascular and exercise physiology
- Clinical Nutrition and Gastroenterology
- Cerebral Palsy and Movement Disorders
- Obesity, Physical Activity, Diet
- Behavioral Health and Interventions
- Musculoskeletal pain and rehabilitation
- Sports Performance and Training
- Health disparities and outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- GDF15 and Related Biomarkers
- Diet and metabolism studies
- Genetic diversity and population structure
- Health Systems, Economic Evaluations, Quality of Life
- Muscle activation and electromyography studies
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
University Hospitals Birmingham NHS Foundation Trust
2019-2025
Versus Arthritis
2020-2025
University of Birmingham
2016-2025
NIHR Birmingham Biomedical Research Centre
2018-2025
National Institute for Health Research
2018-2024
Medical Research Council
2016-2024
Australian Institute for Musculoskeletal Science
2024
Western Health
2024
The University of Melbourne
2024
University of Nottingham
2020-2023
Abstract The unambiguous identification of Central Valley spring‐run chinook salmon has become imperative since their proposed listing in 1998. accuracy methods used to assign individuals stock origin is critical for understanding juvenile migration patterns and determining the success protection measures. Existing microsatellites discriminate between endangered winter‐run other but are insufficient characterize phylogenetically less distinct runs. Here, we isolated developed highly variable...
This cross-sectional study was designed to examine the effects of healthy ageing on muscle strength, power, and potentially related functional ability. Subjects were recruited through local national newspapers inclusion based strict health criteria, by questionnaire. Isometric knee extensor, isometric elbow flexor handgrip leg extensor timed rise from a low chair, lifting weighted bag surface, stepping unaided boxes different heights measured in 50 men women, evenly distributed over age...
Depression is a common and important cause of morbidity mortality worldwide. It commonly treated with antidepressants and/or psychological therapy, but some people prefer alternative approaches such as exercise. There are number theoretical reasons why exercise may improve depression. This an update review first published in 2009.
BackgroundAge-related losses of muscle mass, strength, and function (sarcopenia) pose significant threats to physical performance, independence, quality life. Nutritional supplementation could positively influence aspects sarcopenia thereby prevent mobility disability.ObjectiveTo test the hypothesis that a specific oral nutritional supplement can result in improvements measures sarcopenia.DesignA multicenter, randomized, controlled, double-blind, 2 parallel-group trial among 380 sarcopenic...
To determine the effects of 12 weeks progressive resistance strength training on isometric strength, explosive power, and selected functional abilities healthy women aged 75 over.Subjects were matched for age habitual physical activity then randomly assigned into either a control or an exercise group.The Muscle Function Laboratory, Royal Free Hospital School Medicine, London.Fifty-two recruited through local national newspapers. Five dropped out before seven (4 exercisers 3 controls) during...
The COVID-19 pandemic has had a devastating global impact, with older adults being most at risk of death from the disease. However, acute sarcopenia occurs in survivors COVID-19; and critically unwell patients are risk. Acute is an under-recognised condition muscle insufficiency, defined by declines function and/or quantity within six months, usually following stressor event. This commentary reviews definition mechanisms suggests recommendations for research clinical practice. Research...
The spread of novel SARS-CoV-2 virus, and the disease COVID-19 that is caused by SARS-CoV-2, continues apace. Saving lives slowing worldwide pandemic remain utmost importance to everyone: public, healthcare professionals, scientists, industry governments. It absolutely essential advice given public evidence-based, accurate timely; anything less would mislead has potential cause harm. Popular information channels, such as social media platforms, have been rife with misinformation perpetuated...
Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on definition exists. The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing global conceptual sarcopenia. GLIS steering committee was formed 2019-21 with representatives from all relevant scientific societies worldwide. During time, developed a set statements topic invited members these participate two-phase...
Abstract Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut play a role in anabolic resistance of older muscle, cognition. In this placebo controlled double blinded randomised trial 36 twin pairs (72 individuals), aged ≥60, each pair are block to receive either or prebiotic daily for 12 weeks. Resistance exercise branched chain amino acid (BCAA) supplementation is prescribed all participants. Outcomes physical function The...
The practicalities of conducting exercise studies with elderly and very people have not been well described. In order to help others plan perform such we describe our experience recruiting volunteers, applying selection criteria, measuring strength, power, cardiorespiratory responses, potentially related functional abilities. Exclusion criteria are offered, for safety characterize subjects as free disease which might alter their performance. International agreement on these, or similar,...
A ‘dark morph’ melanic strain of the greater wax moth, Galleria mellonella , was studied for its atypical, heightened resistance to infection with entomopathogenic fungus, Beauveria bassiana . We show that these insects exhibit multiple intraspecific immunity and physiological traits distinguish them from a non-melanic, fungus-susceptible morph. The non-melanic morphs were geographical variants had evolved different, independent defence strategies. Melanic thickened cuticle, higher basal...
Background and Purpose— There is little information on how to best measure poststroke fatigue. Our aim was identify which currently available fatigue scale most valid, feasible, reliable in stroke patients. Methods— Fatigue scales were identified by systematic search, the 5 with face validity expert consensus. Feasibility (ie, did patients provide answers?) internal consistency (an aspect of reliability) these evaluated interviewing 55 Test-retest reliability assessed reinterviewing 51...
Resistance exercise increases muscle mass and function in older adults, but responses are attenuated compared with younger people. Data suggest that long-chain n-3 polyunsaturated fatty acids (PUFAs) may enhance adaptations to resistance women. To our knowledge, this possibility has not been investigated men.
Microevolutionary adaptations and mechanisms of fungal pathogen resistance were explored in a melanic population the Greater wax moth, Galleria mellonella. Under constant selective pressure from insect pathogenic fungus Beauveria bassiana, 25th generation larvae exhibited significantly enhanced resistance, which was specific to this not another fungus, Metarhizium anisopliae. Defense stress management strategies selected (resistant) non-selected (susceptible) lines compared uncover...
OBJECTIVES: To determine the feasibility and effect of exercise training after stroke. DESIGN: Randomized exploratory trial comparing (including progressive endurance resistance training) with relaxation (attention control). SETTING: Interventions were performed in a rehabilitation hospital. PARTICIPANTS: Sixty‐six independently ambulatory patients (mean age 72, 36 men) without significant dysphasia, confusion, or medical contraindications to who had completed their usual been discharged...