A5102809955- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Nutrition and Health in Aging
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Stress Responses and Cortisol
- Vitamin D Research Studies
- Estrogen and related hormone effects
- Thyroid Cancer Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Ovarian function and disorders
- Muscle metabolism and nutrition
- Cancer, Hypoxia, and Metabolism
- Regulation of Appetite and Obesity
- Parkinson's Disease Mechanisms and Treatments
- Bone health and osteoporosis research
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Acute Ischemic Stroke Management
- Menopause: Health Impacts and Treatments
- Neurological disorders and treatments
- Birth, Development, and Health
- Cerebrovascular and Carotid Artery Diseases
- Hypothalamic control of reproductive hormones
University of Parma
2009-2018
Ospedale di Parma
2016
Regione Emilia-Romagna
2014
Yahoo (United Kingdom)
2014
National Institute on Aging
2006-2009
Azienda Sanitaria di Firenze
2006-2009
National Institutes of Health
2005-2009
University of Perugia
2009
University of Naples Federico II
2009
University of Campania "Luigi Vanvitelli"
2009
BackgroundAge-related losses of muscle mass, strength, and function (sarcopenia) pose significant threats to physical performance, independence, quality life. Nutritional supplementation could positively influence aspects sarcopenia thereby prevent mobility disability.ObjectiveTo test the hypothesis that a specific oral nutritional supplement can result in improvements measures sarcopenia.DesignA multicenter, randomized, controlled, double-blind, 2 parallel-group trial among 380 sarcopenic...
Background.Muscle impairment is a common condition in older people and powerful risk factor for disability mortality. The aim of this study was to apply the European Working Group on Sarcopenia Older People criteria estimate prevalence investigate clinical correlates sarcopenia, sample Italian community-dwelling people.
An age-associated decline in testosterone (T) levels and an increase proinflammatory cytokines contribute to chronic diseases older men. Whether how these changes are related is unclear.We hypothesized that T inflammatory markers negatively correlated men.This was a cross-sectional study.A population-based sample of men studied.After excluding participants taking glucocorticoids or antibiotics those with recent hospitalization, 467 men, aged 65 yr older, had complete determinations total T,...
OBJECTIVES: To investigate thyroid function testing abnormalities in older persons and to explore the relationship between dysfunction cognition. DESIGN: Cross‐sectional. SETTING: Community‐based. PARTICIPANTS: One thousand one hundred seventy‐one men women aged 23 102. MEASUREMENTS: Thyroid was evaluated by measuring plasma concentrations of thyrotropin (TSH), free thyroxine (FT4), triiodothyronine (FT3). Cognition using Mini‐Mental State Examination (MMSE). Prevalence overt subclinical...
Background Manual measurement of 4-meter gait speed by a stopwatch is the gold standard test for functional assessment in older adults. However, accuracy this technique may be biased several factors, including intra- and inter-operator variability. Instrumental techniques using accelerometers have higher accuracy. Studies addressing concordance between these two are missing. The aim present community-based observational study was to compare manual instrumental measurements individuals assess...
The use of proton pump inhibitors (PPIs) has rapidly increased during the past several years. However, concern remains about risks associated with their long-term in older populations.To investigate relationship between PPIs and risk death or combined end point rehospitalization patients discharged from acute care hospitals.We investigated PPI study outcomes using time-dependent Cox proportional hazards regression 65 years medical wards April 1 to June 30, 2007.Eleven wards.Four hundred...
Hypothalamic-pituitary-end-organ axes are frequently controlled by long loop negative feedback homeostatic mechanisms. Insulin-like growth factor I (IGF-I), IGF-II, and insulin receptors have recently been described in normal neoplastic rat acromegalic human pituitary cells, a finding which suggests the possibility that somatomedins might exert at level of anterior pituitary. To study kinetics this response, we used perifused dispersed cells to learn if or could inhibit GH-releasing hormone...
Primary cultures of rat anterior pituitary cells were assessed for the presence specific receptors insulin and somatomedin peptides, insulin-like growth factors I II (IGF-I IGF-II). Specific binding per 100,000 averaged 9.45 ± 1.69% (mean sd) [125I]IGF-II, 0.83 0.06% [125I]IGF-I, only 0.11% [125I]insulin. IGF-II was twice as potent IGF-I in displacing while totally nonreactive. 5-fold more than at [125I]IGF-I 1000-fold insulin. Scatchard analysis [125I]IGF-II revealed a curvilinear plot,...
The functional consequences of an age-related insulin resistance (IR) state on muscle functioning are unknown. Because is needed for adequate function, insulin-resistant may also be a determining factor. We evaluated the relationship between IR and handgrip strength in men women from large population-based study (n = 968).The degree was by homeostasis model assessment (HOMA) assessed using handgrip.Simple sex-stratified correlations demonstrated that, men, body mass index-adjusted correlated...
Long-term side effects of high doses anabolic androgenic steroids self-administration were evaluated in this study. Twenty male bodybuilders, voluntarily starting steroid self-administration, followed every 6 months over 2 years. Physical examination, haematological, metabolic and endocrine variables, semen analysis, hepatic prostate ultrasound echocardiographic evaluations performed. LH values (baseline 3.43 +/- 1.75) suppressed at 18 (1.98 1.99) (p = 0.026) 24 (2.43 2.17) 0.026), FSH (3.95...
Poor muscle strength is a major public health concern in older persons, predisposing to functional limitations, increased fall risk, and higher mortality. Understanding risk factors for decline may offer opportunities prevention treatment. One of the possible causes imbalance between catabolic anabolic signaling. This study aims examine whether high levels multiple low biomarkers predict accelerated strength.In representative sample 716 men women aged >or=65 years InCHIANTI we measured...
Summary The stimulatory effects of testosterone on erythropoiesis are very well known, but the mechanisms underlying erythropoietic action still poorly understood, although erythropoietin has long been considered a potential mediator. A total 108 healthy men >65 years old with serum concentration <475 ng/dL were recruited by direct mailings to alumni University Pennsylvania and Temple University, randomized receive 60‐cm 2 or placebo patch for 36 months. Ninety‐six subjects completed...
Background. It has been suggested that the reduced production of dehydroepiandrosterone sulfate (DHEAS) may be partially responsible for decline muscle strength and mass often occurs with aging. However, this hypothesis only tested in small series normal volunteers, little consideration potential confounders. Using data from a representative sample 558 men (20–95 years) we circulating DHEAS is independently associated mass.
OBJECTIVES: To determine whether low levels of testosterone, sex hormone binding globulin (SHBG), insulin‐like growth factor‐1 (IGF‐1), and dehydroepiandrosterone sulfate (DHEAS) high cortisol leptin would be associated with metabolic syndrome (MS). DESIGN: Cross‐sectional. SETTING: Population‐based sample older Italian men. PARTICIPANTS: Four hundred fifty‐two men aged 65 enrolled in the Invecchiare Chianti (InCHIANTI) study. MEASUREMENTS: Complete data on cortisol, DHEAS, SHBG, fasting...
GH secretion is stimulated by hypothalamic GH-releasing factor (GHRH) and inhibited somatostatin. Since induces the production of insulin-like growth factors (IGF) in liver other tissues, it interest to learn whether IGF alters release through long loop feedback inhibition. Pituitary adenomas which had been removed from six acromegalic patients were processed for dispersed cell cultures and/or membrane preparations. Binding studies using 125I-labeled IGF-I, IGF-II, insulin revealed specific...
The isolation and hormonal regulation of two low molecular weight insulin-like growth factor binding proteins (IGFBPs) present in the conditioned medium (CM) rat neuroblastoma cell line B104 cells has been performed. IGFBPs were purified by ZnSO4 precipitation, factor- I 1IGF-I) affinity chromatography, reverse phase HPLC. Final N-terminal analysis was accomplished sodium dodecyl sulfate-polyacrylamide gel electrophoresis, electroblotting to polyvinylidene difluoride membranes, sequencing...