A5053406578- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Phytochemicals and Antioxidant Activities
- Cardiovascular and exercise physiology
- Nutrition and Health in Aging
- Nutritional Studies and Diet
- Antioxidant Activity and Oxidative Stress
- Heart Rate Variability and Autonomic Control
- Obesity, Physical Activity, Diet
- Fatty Acid Research and Health
- Sports Performance and Training
- Atherosclerosis and Cardiovascular Diseases
- Free Radicals and Antioxidants
- Diet and metabolism studies
- Pomegranate: compositions and health benefits
- Angiogenesis and VEGF in Cancer
- Thermoregulation and physiological responses
- Food Security and Health in Diverse Populations
- Nitric Oxide and Endothelin Effects
- High Altitude and Hypoxia
- Psidium guajava Extracts and Applications
- Health and Wellbeing Research
- BRCA gene mutations in cancer
- Maternal Mental Health During Pregnancy and Postpartum
- Obstructive Sleep Apnea Research
De Montfort University
2018-2025
University of Derby
2016-2017
Institute of Medical Sciences
2016
University of Aberdeen
2013-2015
University of Bologna
2011
Resistance exercise increases muscle mass and function in older adults, but responses are attenuated compared with younger people. Data suggest that long-chain n-3 polyunsaturated fatty acids (PUFAs) may enhance adaptations to resistance women. To our knowledge, this possibility has not been investigated men.
Resistance exercise training is known to be effective in increasing muscle mass older people. Acute measurement of protein metabolism data has indicated that the magnitude response may differ between sexes. We compared adaptive responses and function 18 weeks resistance a cohort (>65 years) men women. improved knee extensor maximal torque, 4 m walk time, time complete five chair rises, anatomical cross-sectional area (ACSA) quality with no effect on fat/water ratio or plasma glucose,...
The inhibition of arginase, resulting in higher arginine (ARG) availability for nitric oxide synthesis, may account the putative protective effect homoarginine (HOMOARG) against atherosclerosis and cardiovascular disease. However, uncertainty exists regarding significance HOMOARG-induced arginase vivo. A novel UPLC-MS method, measuring conversion ARG to ornithine (ORN), was developed determine 1 2 by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA),...
ABSTRACT Background and Aims There is emerging evidence that genes, lifestyles environment play a prominent role in the development of non‐communicable diseases. Currently, there not information on people's perception inherited genetics vs. lifestyle disease development. Knowing belief etiology will better inform public health strategies for adoption healthy lifestyle. Methods Individuals aged 18 years over were recruited 2019 among UK population 363 participants completed an anonymous...
ABSTRACT Expected satiety is a key element in predicting meal portion size and food consumption; however, how this can be affected by different breakfast sizes unknown. The study examined the impact of portions on satiety, size, energy intake comprised an online survey experimental intervention. Sixteen adults (9 women, BMI: 24.9 ± 4.3 kg/m 2 ) rated images three (small, standard, large) same using ordinal scale. Subsequently, they were asked to self‐prepare consume ad libitum randomised...
Abstract Serum measurements of 17β‐estradiol and progesterone are widely used to verify menstrual cycle status confirm contraceptive use, often through commercially available immunoassay kits. However, no studies have investigated whether blood collection tube chemistries influence hormone concentrations in young females, despite assays permitting the use different biofluids with similar reference ranges. In this study, venous was sampled from physically active females ( n = 25) using...
This study aimed to evaluate, in swimming, the agreement between anaerobic threshold (AT) as determined from analysis of blood lactate concentration ([La]) and a new method based on heart rate (HR) variability (HRV). Fourteen high-level swimmers completed an incremental 7 × 200-m front crawl test, during which HRV was measured continuously [La] collected after each step. To individuate AT, trends high-frequency spectral power (HFPOW) fraction HFPOW relative respiratory sinus arrhythmia...
Background Krill oil is a rich source of the long-chain n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), which may alter immune function after exercise. The aim study was to determine effects krill supplementation on post exercise performance. Methods Nineteen males 18 females (age: 25.8 ± 5.3 years; mean S.D.) were randomly assigned 2 g/day (n = 18) or placebo 19) for 6 weeks. A maximal incremental test cycling time trial (time complete set...
Endothelial dysfunction (ED), secondary to diminished nitric oxide (NO) production and oxidative stress, is an early subclinical marker of atherosclerosis. Reduced NO bioavailability enhances the adhesion monocytes endothelial cells promotes Elderberry extract (EB) known contain high levels anthocyanins which could exert vascular protective effects. Specifically, we investigated functional capacity EB on various markers ED. Human umbilical vein (HUVEC) were pretreated with 50 μg/mL...
The current study was designed to explore the associations between L-arginine metabolites and muscle mass function in old age, which are largely unknown.
Upper respiratory tract infections (URTI) are a frequent illness among athletes. We investigated the effect of multi-nutrient supplement (vitamin D, fish oil and protein) on occurrence URTI in young active people. 42 recreational athletes were randomly assigned to receive either supplementation (550 mg DHA, 550 EPA, 10 µg vitamin D3 8 g whey or placebo for 16 weeks. Unstimulated saliva samples collected by passive drool. Samples analysed IgA (sIgA) concentration secretion rate extrapolated...
The purpose of this study was to test the hypothesis that Vo2 kinetics would be speeded a greater extent following repeated sprint training (RST), compared with continuous endurance (ET), in transition from moderate- severe-intensity exercise. Twenty-three recreationally active subjects were randomly assigned complete six sessions ET (60-110 min moderate-intensity cycling) or RST (four seven 30-s all-out Wingate tests) over 2-wk period. Subjects completed three identical work-to-work cycling...
Short-term dietary nitrate (NO3−) supplementation has the potential to enhance performance during submaximal endurance, and short-duration, maximal-intensity exercise. However, it yet be determined whether NO3− before endurance exercise can improve a end-sprint. In randomised, double-blind, crossover study, 9 recreationally active men ingested NO3−-rich (BR: 8 mmol NO3−/day) NO3−-depleted (PL: 0.75 beetroot powder for 7 days. On day 7, participants completed 2 h of moderate-intensity...
Sarcopenia is the age-related loss of muscle mass that results in a reduction skeletal function, quality life and an increased risk falls. Older has 'anabolic resistance' to both nutrients exercise, with preciseunderlyingmechanismstilltobeelucidated.Then-3polyunsaturatedfattyacidsfoundinfishoilcanbe incorporatedintothemembranesofskeletalmuscles,wheretheymayhaveanti-inflammatoryeffects.Thisalteration membrane fatty acid composition may have anabolic effects aging and, thus, be useful...
Cold exposure increases blood pressure (BP) and salivary flow rate (SFR). Increased cold-induced SFR would be hypothesized to enhance oral nitrate delivery for reduction nitrite by anaerobes subsequently elevate plasma [nitrite] nitric oxide bioavailability. We tested the hypothesis that dietary supplementation increase lower BP a greater extent in cool compared with normothermic conditions. Twelve males attended laboratory on four occasions. Baseline measurements were completed at 28°C....
: Reduced nitric oxide (NO) bioavailability secondary to excess-superoxide-driven oxidative stress is central endothelial dysfunction. Previous studies suggest that phenolic metabolites may improve NO bioavailability, yet limited research available in response an inflammatory mediator. Therefore, we assessed the effects of cyanidin-3-glucoside (C3G) and its protocatechuic acid (PCA) vanillic (VA) on a TNF-α induced environment.
Trimethylamine N-oxide (TMAO), a gut-derived metabolite and marker of gut dysbiosis, has been linked to hypertension. Blood pressure is proposed be elevated in hormonal contraceptive users males compared age-matched eumenorrheic females, but the extent which TMAO differs between these populations yet investigated. Peripheral central blood were measured, with latter determined via applanation tonometry, plasma concentration was assessed using liquid chromatography-tandem mass spectrometry....
Abstract Funding Acknowledgements Type of funding sources: Other. Main source(s): De Montfort PhD funded scholarship scheme Introduction During the early stages atherosclerosis, monocytes attach to endothelial cells (EC) before differentiating into macrophages causing accumulation foam and plaque growth. NF-κB vascular cell adhesion molecule 1 (VCAM-1) are some main mediators in EC that involved monocyte process. Elderberry extract (EE) rich anthocyanins a subclass polyphenol with...