A5050194744- Vitamin D Research Studies
- Muscle metabolism and nutrition
- melanin and skin pigmentation
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Mobile Health and mHealth Applications
- Allergic Rhinitis and Sensitization
- Osteoarthritis Treatment and Mechanisms
- Genetic Associations and Epidemiology
- Fatty Acid Research and Health
- Spine and Intervertebral Disc Pathology
- Spaceflight effects on biology
- Cardiovascular Health and Risk Factors
- Dermatology and Skin Diseases
- Medical Education and Admissions
- RNA regulation and disease
- Spondyloarthritis Studies and Treatments
- Genetic Mapping and Diversity in Plants and Animals
- Total Knee Arthroplasty Outcomes
- Nutrition and Health in Aging
- Behavioral Health and Interventions
- Musculoskeletal pain and rehabilitation
- Genetics, Aging, and Longevity in Model Organisms
- Dietary Effects on Health
- Gut microbiota and health
King's College London
2007-2025
King's College - North Carolina
2024
Tel Aviv University
2023
St Thomas' Hospital
2007-2021
Bangladesh Atomic Energy Commission
1984
Abstract Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut play a role in anabolic resistance of older muscle, cognition. In this placebo controlled double blinded randomised trial 36 twin pairs (72 individuals), aged ≥60, each pair are block to receive either or prebiotic daily for 12 weeks. Resistance exercise branched chain amino acid (BCAA) supplementation is prescribed all participants. Outcomes physical function The...
Dry eye disease (DED) is common, but little known about factors contributing to symptoms of dry eye, given the poor correlation between these and objective signs at ocular surface.To explore whether pain sensitivity plays a role in patients' experience DED symptoms.A population-based cross-sectional study 1635 female twin volunteers, aged 20 83 years, from TwinsUK adult registry.Dry was diagnosed if participants had least 1 following: (1) diagnosis by clinician, (2) prescription artificial...
Significance The human face is extraordinarily variable, and the extreme similarity of faces identical twins indicates that most this variability genetically determined. We have devised an approach to increase chance identifying specific large genetic effects on particular facial features, by choosing features with high heritability selecting individuals relatively phenotypes for comparison a control population. This has yielded three replicated variants, two profiles, one region around...
Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models osteoarthritis acute inflammatory pain, but has not been studied humans. Our aim was to assess role resolvins heat pain sensitivity D1, D2, D3, D5, E1 17-HDHA, were measured by liquid chromatography-mass spectrometry tested for association with...
Meiotic recombination is a fundamental process that generates genetic diversity by creating new combinations of existing alleles. Although human crossovers have been studied at the pedigree, population and single-cell level, more frequent non-crossover events lead to gene conversion are harder study, particularly individual level. Here we show single high-fidelity long sequencing reads from sperm can capture both non-crossovers, allowing effectively arbitrary sample sizes for analysis one...
Abstract The Personalised REsponses to DIetary Composition Trial (PREDICT) was a single-arm, single-blind intervention study that utilized both standardized “test” meals and captured “free-living” non-standardized food consumption, predict an individual’s metabolic response foods based on the person’s characteristics (including their metabolomic gut microbiome profiles), meal composition (macronutrients energy content) context time of day, sleep exercise). initial commenced in June 2018...
Abstract Introduction Intervertebral disc degeneration and Modic change are the main spinal structural changes associated with chronic low back pain (LBP). Both conditions thought to manifest local inflammation if inflammatory proteins translocate blood circulation could be detected systemically. The work here assesses whether presence of is detectable level five markers LBP these changes. Materials Methods Two hundred forty TwinsUK cohort participants both MRI grade extent, IL‐6, IL‐8, IL‐8...
Abstract Background Loss of skeletal muscle mass and strength occurs with increasing age is associated loss function, disability, the development sarcopenia frailty. Dietary protein essential for but older adults do not anabolise in response to supplementation as well younger people, so called ‘anabolic resistance’. The aetiology molecular mechanisms this are understood, however gut microbiome known play a key role several proposed mechanisms. Thus, we hypothesise that may mediate anabolic...
Abstract As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ( 1–10 . Some of these represent a first step towards cancer whereas others may contribute to ageing and other diseases. However, our understanding the clonal landscapes human tissues, their impact on risk, disease, remains limited due challenge detecting present in small numbers cells. Here, introduce new version nanorate sequencing (NanoSeq) 11 , duplex method with error rates <5...
Abstract Introduction The PROMOTe trial was conducted entirely remotely, which aimed to enable a wider recruitment of participants, minimised risk Covid-19 exposure and adhere former travel restrictions. Participant experiences with remote clinical trials are not well understood. This work characterise participant perspectives on the delivery trial. Methods involved measurement short physical performance battery grip strength, collection stool, urine, saliva, capillary blood. Equipment...
Objective The chronic pain syndromes (CPS) include such as widespread (CWP), dry eye disease (DED) and irritable bowel syndrome (IBS). Highly prevalent lacking pathognomonic biomarkers, the CPS are known to cluster in individuals part due their genetic overlap, but patient diagnosis can be difficult. success of quantitative sensory testing (QST) inflammatory biomarkers phenotyping tools conditions painful neuropathies warrant investigation CPS. We aimed examine whether individual QST...
Abstract In order to discover specific variants with relatively large effects on the human face we have devised an approach identifying facial features high heritability. This is based using twin data estimate additive genetic value of each point a face, as provided by 3D camera system. addition, used ethnic difference between East Asian and European faces further source variation. We use principal components analysis provide fine definition surface around eyes profile, chose upper lower 10%...
Age-related hearing impairment (ARHI) is prevalent in older adults, affecting at least 60% of people by the time they reach 71 to 80 years age.1 The number with ARHI will necessarily increase as humans live longer and a greater proportion population older.2 Hearing loss does not just impact communication; it associated loneliness depression, cognitive decline dementia, well reduced physical well-being.3-6 A decade ago, an international report calculated that cost Europe £213 billion...