A5021460816- Ocular Surface and Contact Lens
- Allergic Rhinitis and Sensitization
- Glaucoma and retinal disorders
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Schizophrenia research and treatment
- Olfactory and Sensory Function Studies
- Salivary Gland Disorders and Functions
- Diet and metabolism studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ophthalmology and Visual Impairment Studies
- Pain Mechanisms and Treatments
- Corneal surgery and disorders
- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Corneal Surgery and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Asthma and respiratory diseases
- Diabetes Treatment and Management
- Contact Dermatitis and Allergies
- Receptor Mechanisms and Signaling
- Bipolar Disorder and Treatment
- Circadian rhythm and melatonin
- Advancements in Transdermal Drug Delivery
King's College London
2016-2025
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Sykehuset i Vestfold
2021-2025
St Thomas' Hospital
2015-2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Liechtenstein Institute
2024
Rotterdam Eye Hospital
2021-2023
Rijnstate Hospital
2019-2021
To estimate the prevalence and risk factors of dry eye disease (DED) in a female cohort UK.Population-based cross-sectional association study 3824 women from TwinsUK aged 20-87 years. A questionnaire was used to evaluate DED several factors. Binary logistic regression, corrected for age, examine between factors.9.6% had diagnosis concomitant use artificial tears, 20.8% experienced symptoms past 3 months. Risk that were significantly associated with asthma, eczema, presence any allergy,...
Chronic pain syndromes (CPS) are highly prevalent in the general population, and increasingly evidence points to a common etiological pathway. Using large cohort of twins (n=8564) characterized for chronic widespread musculoskeletal (CWP), pelvic (PP), migraine (MIG), dry eye disease, irritable bowel syndrome (IBS), we explored underlying genetic environmental factors contributing CPS correlation between them. The sample was predominantly female (87.3%), with mean age 54.7 (±14.7) years....
This large cross-sectional population-based study investigated the relationship between dry eye disease (DED) and health-related quality of life (HR-QoL). Dry HR-QoL were assessed in 78,165 participants (19–94 yrs, 59.2% female) from Dutch Lifelines cohort, using WHS SF36 questionnaire, respectively. Logistic regression was used to assess DED below median Physical Component Summary (PCS) Mental (MCS) score, corrected for age, sex, education, BMI, 52 comorbidities. Overall, 8.9% had DED....
Sleep is an important determinant of health and quality life. This study aimed to clarify the association between dry eye sleep using a large population-based cohort. 71,761 participants (19–94 yrs, 59.4% female) from Lifelines cohort in Netherlands were assessed for Women's Health Study Dry Eye Questionnaire. was evaluated Pittsburgh Quality Index (PSQI). Logistic regression used examine relationship poor (PSQI score >5) eye, while correcting age, sex, BMI, education, income, 51 possible...
Abstract Tear fluid is emerging as a source of non-invasive biomarkers, both for ocular and systemic conditions. Accurate quantification tear proteins can be improved by standardizing methods to collect process fluid. The aim this study was determine sample handling factors that may influence the protein biomarker profile. collected using Schirmer’s strips. were extracted elution through centrifugation. Total content determined bicinchoninic acid assay. Key concepts apply entire processing...
Dry eye disease (DED) is common, but little known about factors contributing to symptoms of dry eye, given the poor correlation between these and objective signs at ocular surface.To explore whether pain sensitivity plays a role in patients' experience DED symptoms.A population-based cross-sectional study 1635 female twin volunteers, aged 20 83 years, from TwinsUK adult registry.Dry was diagnosed if participants had least 1 following: (1) diagnosis by clinician, (2) prescription artificial...
To investigate the relationship between dry eye disease (DED) and vision-related quality of life (VR-QoL) at population level.DED VR-QoL were assessed in 89,022 participants (18-96 years, 59% female) from Dutch population-based Lifelines cohort using Women's Health study (WHS) Visual function 25 (VFQ25) questionnaires. The DED compromised was with logistic regression, corrected for age, sex, BMI, income, education, smoking, 55 comorbidities.9.1% had DED. higher risk average ten domains (OR...
To investigate the relationship between dry eye disease (DED) and work functioning, unemployment, absenteeism, worry about job loss.DED 'worry loss' were assessed in 71,067 subjects (18-65 years, 60% female) from Dutch population-based Lifelines cohort using Women's Health study questionnaire single-item questions, respectively. Work functioning was 32,475 participants role 2.0. The relationships DED measures with logistic regression models, corrected for age, sex, BMI, income, educational...
<h3>Purpose</h3> To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach. <h3>Design</h3> Cross-sectional study. <h3>Participants</h3> A total of 2819 subjects from population-representative TwinsUK cohort in United Kingdom, with mean age 57 years (range, 17–82 years). <h3>Methods</h3> We tested associations 222 known DED. All underwent nontargeted metabolomic analysis plasma samples gas liquid chromatography combination mass...