A5038567756- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Birth, Development, and Health
- Ion Transport and Channel Regulation
- Epigenetics and DNA Methylation
- Sodium Intake and Health
- Single-cell and spatial transcriptomics
- Ion channel regulation and function
- Renal function and acid-base balance
- Cytomegalovirus and herpesvirus research
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Health, Environment, Cognitive Aging
- Skin Protection and Aging
- Nutritional Studies and Diet
- Receptor Mechanisms and Signaling
- Frailty in Older Adults
- Hormonal Regulation and Hypertension
- Trace Elements in Health
- Mesenchymal stem cell research
- Nutrition and Health in Aging
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
Rutgers, The State University of New Jersey
2016-2025
Rutgers New Jersey Medical School
2014-2023
University of Washington
2015-2019
Google (United States)
2018
Inserm
2000-2017
Centre Hospitalier Régional et Universitaire de Nancy
2004-2017
Université de Lorraine
2017
Institut National de Recherche en Santé Publique
2017
University of Groningen
2016
University of Utah
2015
Identifying reliable biomarkers of aging is a major goal in geroscience.While the first generation epigenetic were developed using chronological age as surrogate for biological age, we hypothesized that incorporation composite clinical measures phenotypic capture differences lifespan and healthspan may identify novel CpGs facilitate development more powerful biomarker
It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates consolidated into a powerful predictor of lifespan. We present here, seven DNAm-based estimators proteins including those plasminogen activator inhibitor 1 (PAI-1) growth differentiation factor 15. The lifespan, DNAm GrimAge (in units years), is composite biomarker estimator smoking pack-years. Adjusting for chronological age generated novel measure...
Chronological age is the primary determinant of stiffness central arteries. Increased an independent indicator cardiovascular risk. The aim this study was to determine whether telomere length, a possible index biological aging, provides better account than chronological for variation in arterial stiffness, evaluated by measuring pulse pressure and aortic wave velocity. population included 193 French subjects (120 men, 73 women), with mean 56±11 years, who were not on any antihypertensive...
Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings leukocytes cannot be generalized to other tissues. Here we measure length leukocytes, skeletal muscle, skin and subcutaneous fat 87 adults (aged 19–77 years). Telomeres are longest muscle shortest yet strongly correlated between Notably, the rates similar four We infer from these that differences...
DNA methylation (DNAm)-based biomarkers of aging have been developed for many tissues and organs. However, these sub-optimal accuracy in fibroblasts other cell types used ex vivo studies. To address this challenge, we a novel highly robust DNAm age estimator (based on 391 CpGs) human fibroblasts, keratinocytes, buccal cells, endothelial lymphoblastoid skin, blood, saliva samples. High correlations can also be observed sorted neurons, glia, brain, liver, even bone Gestational correlates with...
Summary Insulin resistance and oxidative stress are associated with accelerated telomere attrition in leukocytes. Both also implicated the biology of aging aging‐related disorders, including hypertension. We explored relations leukocyte length, expressed by terminal restriction fragment (TRF) insulin resistance, measured TRF length 327 Caucasian men a mean age 62.2 years (range 40–89 years) from Offspring cohort Framingham Heart Study. was inversely correlated ( r = –0.41, P < 0.0001)...
The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.
Telomere length within an individual varies in a correlated manner across most tissues.
Background— Insulin resistance predisposes to cardiovascular disease and shortens human lifespan. We therefore tested the hypothesis that a rise in insulin concert with gain body mass is associated accelerated white blood cell telomere attrition. Methods Results— measured dynamics age-related changes index young adults of Bogalusa Heart Study. Over 10.1 12.8 years, relative length were correlated homeostasis model assessment ( r =−0.531, P <0.001) =−0.423, <0.001). Conclusions— These...
Leukocyte telomere length (LTL) is ostensibly a bio-indicator of human aging. Here we report that African Americans have longer LTL than whites. We studied cross-sectionally 2453 individuals from the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study (age = 30-93 years) Bogalusa 19-37 years), comprising 1742 whites 711 Americans. measured by Southern blots terminal restriction fragments length. In 234 participants, repeats were also quantitative polymerase chain reaction...
An epigenetic profile defining the DNA methylation age (DNAm age) of an individual has been suggested to be a biomarker aging, and thus possibly providing tool for assessment health mortality. In this study, we estimated DNAm 378 Danish twins, 30–82 years, furthermore included 10-year longitudinal study 86 oldest-old twins (mean 86.1 at follow-up), which subsequently were followed mortality 8 years. We found that is highly correlated with chronological across all groups (r = 0.97), but rate...
Telomere length (TL) is associated with several aging-related diseases.Here, we present a DNA methylation estimator of TL (DNAmTL) based on 140 CpGs.Leukocyte DNAmTL applicable across the entire age spectrum and more strongly than measured leukocyte (LTL) (r ~-0.75 for versus r ~ -0.35 LTL).Leukocyte outperforms LTL in predicting: i) time-to-death (p=2.5E-20),ii) time-tocoronary heart disease (p=6.6E-5),iii) time-to-congestive failure (p=3.5E-6), iv) association smoking history...
Leukocyte telomere length (LTL) is related to diseases of aging, but studies mortality have been inconsistent. We evaluated LTL in relation total and specific cause death 1,136 participants the Cardiovascular Health Study who provided blood samples 1992–1993 survived through 1997–1998. was measured by Southern blots terminal restriction fragments. Cause classified a committee physicians reviewing certificates, medical records, informant interviews. A 468 (41.2%) deaths occurred over 6.1...
Telomeres are engaged in a host of cellular functions, and their length is regulated by multiple genes. Telomere shortening, the course somatic cell replication, ultimately leads to replicative senescence. In humans, rare mutations genes that regulate telomere have been identified monogenic diseases such as dyskeratosis congenita idiopathic pulmonary fibrosis, which associated with shortened leukocyte (LTL) increased risk for aplastic anemia. Shortened LTL observed aging-related complex...
In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women offspring conceived by older fathers. Although short LTL associated with atherosclerotic cardiovascular disease, long major cancers. The prevailing notion that a "telomeric clock," whose movement (expressed attrition) reflects the pace of aging. Accordingly, individuals are considered to be biologically than their peers. Recent studies suggest largely determined before adulthood. We examined whether factors...
Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival the elderly. LTL dynamics are defined by at birth, which highly variable, its age-dependent attrition thereafter, rapid during first 20 years of life. We examined whether adulthood can substantially affect individuals' ranking (e.g., longer or shorter LTL) relation to their peers. measured samples donated 12 apart on average 1156 participants four longitudinal studies. observed...
Abstract Telomeres play a key role in replicative ageing and undergo age-dependent attrition vivo. Here, we report novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, show that TelSeq results correlate with Southern blot measurements of the mean terminal restriction fragments (mTRFs) display comparably well as mTRFs.
<h3>Background</h3> Leucocyte telomere length (LTL) is a complex trait associated with ageing and longevity. LTL dynamics are defined by its age-dependent attrition. Strong, but indirect evidence suggests that at birth attrition during childhood largely explains interindividual variation among adults. A number of studies have estimated the heritability LTL, none has assessed <h3>Methods</h3> We examined based on longitudinal evaluation (an average follow-up 12 years) in 355 monozygotic 297...