Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings leukocytes cannot be generalized to other tissues. Here we measure length leukocytes, skeletal muscle, skin and subcutaneous fat 87 adults (aged 19–77 years). Telomeres are longest muscle shortest yet strongly correlated between Notably, the rates similar four We infer from these that differences...

The h-index is a measure designed to assess the quantity and significance of an individual's academic contributions. objective this study was determine whether plastic surgeons correlates with rank there difference based on rank, residency training model, sex, geographic region, faculty size, departmental status.A database all US created. sex each surgeon were obtained, as characteristics their surgery program. Scopus queried surgeon's h-index.The 592 in our had mean 8.97. increased rank:...

The defect resulting from partial or complete maxillectomy can often be reconstructed with a skin graft and prosthesis. In situations where this simple maneuver is unsatisfactory, more complex reconstructive modality, providing the restoration of composite tissue, required. scapular microvascular-free flap was used in series 11 patients, as cutaneous 3 an osteocutaneous 8, to meet specific needs each patient. Excellent satisfactory facial contour palatal function achieved 10 patients. There...

Background: Standard isolation of adipose stromal vascular fraction (SVF) requires the use collagenase and is considered more than “minimally manipulated” by current good manufacturing practice requirements. Alternatively, nonenzymatic methods have surfaced using physical forces to separate cells from matrix. The purpose this study was review literature on mechanical protocols compare results. implication for as a standard procedure in discussed. Methods: A systematic performed SVF with...

Staphylococcal extracellular polymeric substances (EPS) such as DNA (eDNA) and poly-N-acetylglucosamine surface polysaccharide (PNAG) mediate numerous virulence traits including host colonization antimicrobial resistance. Previous studies showed that EPS-degrading enzymes increase staphylococcal biocide susceptibility in vitro vivo, decrease animal models. In the present study we tested effect of on skin povidone iodine using a novel vivo pig model enabled us to colonize treat 96 isolated...

Tumor angiogenesis has recently been related to tumor growth and metastasis, which determine the clinical outcome of patient. This study was designed relationship between in primary squamous cell carcinomas (SSC) head neck development recurrent or metastatic disease, both. Different SCC were studied. Microvessels selectively stained using a monoclonal antibody for factor VIII. Microvessel counts performed tumor, tissues immediately adjacent, normal similar topographies. then correlated with...

A new method for the reconstruction of large thora-columbar and lumbosacral meningomyelocele defects is described in which latissimus dorsi gluteus maximus myocutaneous units are advanced medially reapproximated midline, permitting primary closure defect three layers. The flaps based on thoracodorsal superior gluteal vessels intervening thoracolumbar fascia, providing tension-free, durable, viable soft-tissue coverage over dural repair. No lateral relaxing incisions, delays, or skin grafts...

ABSTRACT Current concepts of wound healing acknowledge the essential role bed preparation in achieving a with good potential. Critical to is removal necrosis, unhealthy tissue, foreign matter, and infection. One accepted methods surgery. The high‐power parallel waterjet new surgical device, which allows operator remove very precisely undesirable tissue debris maximal preservation viable tissue. A retrospective study was performed evaluate efficacy, safety, economic impact using this...

A new cell‐tissue technology uses a patient's skin to create an in vivo expanding and self‐organising full‐thickness autograft derived from potent cutaneous appendages. This autologous homologous construct (AHSC) is manufactured small harvest obtained uninjured area of the patient. All harvested tissue incorporated into AHSC including endogenous regenerative cellular populations responsible for maintenance repair, which are activated during manufacturing process. Without any exogenous...

Thrombospondin is a high molecular weight adhesive glycoprotein that has been shown to function in mechanisms of tumor progression. The authors' previous studies have thrombospondin promotes human lung carcinoma invasion by up-regulation the plasminogen activator system through mechanism involving activation transforming growth factor-beta 1 (TGF-beta 1). In this study, similar thrombospondin-mediated operative breast cells described.The effect and TGF-beta on capacity line activate was...

Abstract The scapular osteocutaneous free flap provides excellent tissue for reconstruction of massive lower facial defects. Five cases full‐thickness cheek and lip defects associated with mandibular loss were successfully repaired sandwiched flaps plus a parascapular or latissimus dorsi flap. In two instances the was harvested along skin paddle. other three patients had myocutaneous units taken from same subscapular pedicle.

Cerebellopontine angle (CPA) meningiomas constitute about 1% of intracranial meningiomas. The clinical aspects a series 32 patients with surgically confirmed CPA are analyzed. most common symptoms at the time initial evaluation were from eighth cranial nerve (unilateral hearing loss — 24 patients, vertigo or imbalance 19 tinnitus 11 patients), and fifth (altered sensation 9 facial pain 5 patients). On examination, findings absent caloric response (19 nystagmus (16 diminished (14 ataxia (13...