Valérie Gaborieau
A5055784647- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Renal cell carcinoma treatment
- Estrogen and related hormone effects
- COVID-19 Clinical Research Studies
- Viral-associated cancers and disorders
- Cytokine Signaling Pathways and Interactions
- Esophageal Cancer Research and Treatment
- HER2/EGFR in Cancer Research
- DNA Repair Mechanisms
- Cervical Cancer and HPV Research
- Long-Term Effects of COVID-19
- Health, Environment, Cognitive Aging
- Lymphoma Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Occupational and environmental lung diseases
- Lung Cancer Treatments and Mutations
- Genomics and Chromatin Dynamics
- Nutrition, Genetics, and Disease
Centre International de Recherche sur le Cancer
2016-2025
Centre Hospitalier De Pau
2008-2025
Johns Hopkins Hospital
2024
Assistance Publique – Hôpitaux de Paris
2024
Université Paris Cité
2024
Stichting HIV Monitoring
2023
Inserm
2023
Institut Bergonié
2023
Université de Bordeaux
2023
Amsterdam University Medical Centers
2023
The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved susceptibility to etiologically complex disease. We conducted a GWAS identify upper aero-digestive tract (UADT) cancers. genotyping was carried out using the Illumina HumanHap300 beadchips 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre studies, as well 4,821 generic controls. The 19 top-ranked variants were investigated further an additional 6,514...
Circulating tumor DNA (ctDNA) is emerging as a key potential biomarker for post-diagnosis surveillance but it may also play crucial role in the detection of pre-clinical cancer. Small-cell lung cancer (SCLC) an excellent candidate early given there are no successful therapeutic options late-stage disease, and displays almost universal inactivation TP53. We assessed presence TP53 mutations cell-free (cfDNA) extracted from plasma 51 SCLC cases 123 non-cancer controls. identified using pipeline...
Abstract International differences in the incidence of many cancer types indicate existence carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to burden 1 . In clear cell renal carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do explain geographical variation its 2 Underlying causes can be inferred sequencing genomes cancers from populations with different rates detecting patterns somatic...
Ambulatory blood pressure (BP) monitoring and home measurements predicted the presence of target organ damage risk cardiovascular events better than did office pressure.To compare these two methods in their correlation with damage, we consecutively included 325 treated (70%) or untreated hypertensives (125 women, mean age = 64.5 +/- 11.3) (three at consultations), morning evening over 3 days) 24-h ambulatory monitoring. Target organs were evaluated by ECG, echocardiography, carotid...
Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein–Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation an independent replication series, to identify common genetic variants associated total subtypes defined EBV Multiple logistic regression was used calculate...
Background Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists to whether this is a direct association, or the 15q variant simply proxy increased exposure tobacco carcinogens. Methods We performed detailed analysis of one single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and total 17 300 subjects from five LC studies four upper aerodigestive tract (UADT) studies. Results Subjects minor allele smoked on...
Genome-wide association studies have identified variants on chromosome 15q25.1 that increase the risks of both lung cancer and nicotine dependence associated smoking behavior.However, there remains debate as to whether with is direct or mediated by pathways related behavior.Here, authors apply a novel method for mediation analysis, allowing gene-environment interaction, case-control study (1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004) conducted at...
Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation general population cohorts. We performed a study sample young adults enriched for extremely overweight individuals. aimed to identify new loci and ascertain whether using an extreme sampling design would the known be populations.From two large Danish cohorts we selected all men women (n = 2,633), equal numbers population-based controls...
Human papillomavirus (HPV) is causally implicated in a subset of cancers the upper aero-digestive tract (UADT).Associations between type-specific HPV antibodies were examined among 1496 UADT cancer case subjects and 1425 control by estimating odds ratios (ORs) logistic regression analyses adjusted for potential confounders. The agreement serology tumor markers infection, including presence DNA p16 expression, tumors.HPV16 L1 seropositivity was associated with increased risk oral cavity...
Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating variant, rs11571833 (K3326X), has been associated with a 2.5-fold lung squamous cell carcinoma but only modest 26% in cancer risk. We analyzed the association between SNP and upper aerodigestive tract (UADT) multivariable unconditional logistic regression adjusted by sex combinations study country for 5942 UADT case patients 8086 control from nine different studies. All statistical tests...