A5074669868- Global Maternal and Child Health
- Malaria Research and Control
- Energy and Environment Impacts
- Esophageal Cancer Research and Treatment
- Mosquito-borne diseases and control
- Air Quality and Health Impacts
- Healthcare Systems and Reforms
- Child Nutrition and Water Access
- Global Public Health Policies and Epidemiology
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- COVID-19 impact on air quality
- Energy, Environment, and Transportation Policies
- Hybrid Renewable Energy Systems
- Esophageal and GI Pathology
- Primary Care and Health Outcomes
- Blood Pressure and Hypertension Studies
- Global Cancer Incidence and Screening
- Pharmaceutical Economics and Policy
- Vector-borne infectious diseases
- Climate Change and Health Impacts
- Chronic Disease Management Strategies
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
Moi University
2016-2025
University of Eldoret
2011-2021
Icahn School of Medicine at Mount Sinai
2020
Purdue University West Lafayette
2020
Duke University Hospital
2020
Keck Hospital of USC
2020
Duke University
2014-2020
National Cancer Institute
2017-2018
University of California, San Francisco
2018
Tenwek Hospital
2018
Global efforts are underway to develop and promote improved cookstoves which may reduce the negative health environmental effects of burning solid fuels on environment. Behavioral studies have considered cookstove user practices, needs preferences in design implementation projects; however, these not examined implications traditional stove use across multiple resource-poor settings promotion projects that utilize a single, standardized design. We conducted in-depth interviews direct...
BackgroundRelatively clean cooking fuels such as liquefied petroleum gas (LPG) emit less fine particulate matter (PM2·5) and carbon monoxide (CO) than polluting (eg, wood, charcoal). Yet, some interventions have not achieved substantial exposure reductions. This study evaluates determinants of between-community variability in exposures to household air pollution (HAP) across sub-Saharan Africa.MethodsIn this measurement study, we recruited households primarily with LPG or exclusively wood...
Abstract Background Simple modifications of typical rural house design can be an effective and relatively inexpensive method reducing indoor mosquito vector densities consequently decreasing malaria transmission. Public health scientists have shown the potential for to protect people against malaria, yet this type intervention remains virtually ignored. A randomized-controlled study was, therefore, undertaken determine effects control on density resting vectors in a rice irrigation scheme...
There are no studies of oral health in relation to esophageal cancer Africa, or Eastern Africa's endemic dental fluorosis, an irreversible enamel hypo-mineralization due early-life excessive fluoride intake. During 2014-18, we conducted a case-control study squamous cell Eldoret, western Kenya. Odds ratios (AORs (95% confidence intervals)) were adjusted for design factors, tobacco, alcohol, ethnicity, education, hygiene and missing/decayed teeth. Esophageal cases (N = 430) had poorer than...
Approximately 2.8 billion people rely on polluting fuels (e.g. wood, kerosene) for cooking. With affordability being a key access barrier to clean cooking fuels, such as liquefied petroleum gas (LPG), pay-as-you-go (PAYG) LPG smart meter technology may help resource-poor households adopt by allowing incremental fuel payments. To understand the potential PAYG facilitate cooking, objective evaluations of customers' and spending patterns are needed. This study uses novel data collected between...
Abstract Household transitions to cleaner cooking fuels (for example, liquefied petroleum gas (LPG)) have historically been studied from a demand perspective, with clean energy usage expected increase improvements in household socio-economic status. Although recent studies demonstrate the importance of supply-side determinants increasing cooking, few large-scale assessed their quantitatively, relative demand-related factors. Here, as part CLEAN-Air(Africa) study, we examine population-based...
Tobacco use is a well-established risk factor for oesophageal squamous cell carcinoma (ESCC) but the extent of its contribution to disease burden in African cancer corridor has not been comprehensively elucidated, including by type tobacco use. We investigated (smoking and smokeless) ESCC Tanzania, Malawi Kenya. Hospital-based case-control studies were conducted three countries. Incident cases controls interviewed using comprehensive questionnaire which included questions on smoking...
Abstract Epigenetic mechanisms such as aberrant DNA methylation (DNAme) are known to drive esophageal squamous cell carcinoma (ESCC), yet they remain poorly understood. Here, we studied tumor-specific DNAme in ESCC cases from nine high-incidence countries of Africa, Asia, and South America. Infinium MethylationEPIC array was performed on 108 tumors 51 normal tissues adjacent the (NAT) discovery phase, targeted pyrosequencing 132 36 NAT replication phase. Top genes for were prioritized by...
Over 900 million people in sub-Saharan Africa (SSA) live energy poverty, relying on cooking polluting fuels (e.g. wood, charcoal). The association between poverty and mental/physical health-related quality of life (HRQoL) among women SSA, who are primarily tasked with cooking, is unknown.Females (n = 1,150) from peri-urban Cameroon, Kenya Ghana were surveyed their household use health status using the standardized Short-Form 36 (SF-36) questionnaire. Random effects linear regression linked...
Background: Tuberculosis (TB) and HIV co-infections have a global prevalence with devastating morbidity massive mortality, Sub-Saharan Africa being the worst hit.Objectives: To evaluate of TB-HIV co-infection demonstrate confusion caused by NTM HIV/AIDS in TB diagnosis treatment western Kenya.Methods: In cross-sectional study carried out at 10 hospitals Kenya, sputa from consenting 872 suspects underwent microscopy, culture on Lowenstein-Jensen Mycobacteria Growth Index Tube media. Isolates...
Pregnancy related complications may result in maternal deaths post delivery especially developing countries. Skilled deliveries and postnatal care (PNC) use Kenya is low. The objective of this study was to identify the determinants PNC use. Demographic Health Survey (2008-09 KDHS) women's data were analyzed. Overall from 3,970 women Results indicate that 47 percent received services. Factors associated with are mothers' age at last child, 4+ ANC visits, urban residence, skilled delivery....
Maternal health service coverage in Kenya remains low, especially rural areas where 63% of women deliver at home, mainly because facilities are too far away and/or they lack transport. The objectives the present study were to (1) determine association between place delivery and distance a household from nearest facility (2) demographic characteristics households with within surveillance system (DSS).Census sampling was conducted for 13,333 Webuye area 2008-2009. Information collected on...
Malaria rapid diagnostic tests (RDTs) are a simple, point-of-care technology that can improve the diagnosis and subsequent treatment of malaria. They an increasingly common tool, but concerns remain about their use by community health workers (CHWs). These regard long-term trends relating to infection prevention measures, interpretation test results adherence protocols. This study assessed whether CHWs maintained competency at conducting RDTs over 12-month timeframe, if this varied with...
Oesophageal squamous cell carcinoma (ESCC) has markedly high incidence rates in Kenya and much of East Africa, with a dire prognosis poorly understood aetiology. Consumption hot beverages—a probable carcinogen to humans—is associated increased ESCC risk other settings is habitually practiced Kenya. We conducted case–control study Eldoret, western between August 2013 March 2018. Cases were patients endoscopically confirmed oesophageal cancer whose histology did not rule out ESCC. Age...