Claire M. Healy
A5071615775- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Esophageal Cancer Research and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Spectroscopy and Chemometric Analyses
- RNA modifications and cancer
- Oral microbiology and periodontitis research
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Bacterial Infections and Vaccines
- Folate and B Vitamins Research
- Oral health in cancer treatment
- Oral and gingival health research
- Cleft Lip and Palate Research
- Pneumonia and Respiratory Infections
- Oral and Maxillofacial Pathology
- Autoimmune and Inflammatory Disorders
- Genetic factors in colorectal cancer
- Otolaryngology and Infectious Diseases
- Occupational and environmental lung diseases
Trinity College Dublin
2016-2025
Dublin Dental University Hospital
2016-2025
Royal College of Surgeons in Ireland
2007-2025
Cancer Genetics (United States)
2024
Yale New Haven Hospital
2024
Centre International de Recherche sur le Cancer
2013-2023
Marymount University
2021
Trinity College
2020
Cork University Hospital
2020
Health Awareness (United States)
2010-2019
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D 1467 matched controls, each characterized measures glucose metabolism, lipids, obesity, blood pressure. With collaborators (FUSION WTCCC/UKT2D), we identified confirmed three loci associated T2D-in a noncoding region near CDKN2A CDKN2B, an intron IGF2BP2, CDKAL1-and replicated...
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved susceptibility to etiologically complex disease. We conducted a GWAS identify upper aero-digestive tract (UADT) cancers. genotyping was carried out using the Illumina HumanHap300 beadchips 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre studies, as well 4,821 generic controls. The 19 top-ranked variants were investigated further an additional 6,514...
Passively acquired maternal antibodies protect infants from many pathogens. With increasing reports of infant pertussis, we evaluated pertussis in maternal-infant paired sera 1999-2000.Antibodies to toxin (PT), filamentous hemagglutinin (FHA), and fimbrial proteins (FIM) were measured by validated IgG-specific enzyme-linked immunosorbant assay (ELISA) 64 maternal-umbilical cord serum pairs 61 sera. Geometric mean concentrations (GMCs) : GMC ratios calculated.Mean age gestation 29.7 years...
In 2006, the Advisory Committee on Immunization Practices recommended tetanus, diphtheria, acellular pertussis (Tdap) vaccination of all caregivers infants aged <1 year ("cocooning") to prevent pertussis-related complications and deaths. We implemented cocooning in a predominantly Hispanic, medically underserved, uninsured population at Houston hospital. Phase 1 (January 2008-January 2010) provided maternal postpartum Tdap vaccine; 2 (June 2009-January also vaccinated infant contacts...
Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein–Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation an independent replication series, to identify common genetic variants associated total subtypes defined EBV Multiple logistic regression was used calculate...
Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have too small examine the associations by subsite, age, sex, global region calendar time explain association in terms of behavioral risk factors. Individual participant data 23,964 cases 31,954 controls from 31 27 countries pooled random effects models. Overall, low education was an increased (OR = 2.50; 95% CI 2.02 – 3.09). Overall one‐third not explained differences...
Background: Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role major risk factors family history HNC older patients. Methods: pooled data from 25 case-control studies conducted separate analyses for ≤45 years old ('young adults', 2010 cases 4042 controls) >45 ('older 17 700 22 704 controls). Using logistic regression with treated as random effects, we estimated adjusted odds ratios (ORs) 95% confidence intervals (CIs). Results:...
Background Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists to whether this is a direct association, or the 15q variant simply proxy increased exposure tobacco carcinogens. Methods We performed detailed analysis of one single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and total 17 300 subjects from five LC studies four upper aerodigestive tract (UADT) studies. Results Subjects minor allele smoked on...
Oral leukoplakia presents as a white patch on the oral mucosa and is recognised having significant malignant potential. Although colonisation of these patches with Candida albicans common, little known about bacterial microbiota patches. In current study we analysed microbiome in 36 patients compared to healthy mucosal tissue from same control subjects determine if specific microbial enrichments could be identified early process that play role progression. This was carried out by sequence...
Human papillomavirus (HPV) is causally implicated in a subset of cancers the upper aero-digestive tract (UADT).Associations between type-specific HPV antibodies were examined among 1496 UADT cancer case subjects and 1425 control by estimating odds ratios (ORs) logistic regression analyses adjusted for potential confounders. The agreement serology tumor markers infection, including presence DNA p16 expression, tumors.HPV16 L1 seropositivity was associated with increased risk oral cavity...
Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating variant, rs11571833 (K3326X), has been associated with a 2.5-fold lung squamous cell carcinoma but only modest 26% in cancer risk. We analyzed the association between SNP and upper aerodigestive tract (UADT) multivariable unconditional logistic regression adjusted by sex combinations study country for 5942 UADT case patients 8086 control from nine different studies. All statistical tests...
Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity duration, as joint continuous exposures, on HNC risk. Data from 26 case-control studies in INHANCE Consortium were used, including never current drinkers who drunk ≤10 drinks/day ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal 3340 laryngeal cancers). The dose-response relationship between exposure drinking duration was...
Renal-transplant recipients are known to have increased rates of skin cancer associated with exposure the sun. Little is known, however, about prevalence and histologic features lesions lips in these patients, or risk factors for such lesions.We examined 160 renal-transplant (105 men 55 women; mean [+/- SD] age, 48 +/- 13 years) normal subjects matched transplant sex, type. The length time between transplantation examination was 69 52 months; 58 percent had received their grafts more than 60...