A5083950596- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Virology and Viral Diseases
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Liver Disease and Transplantation
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Urologic and reproductive health conditions
- Autoimmune and Inflammatory Disorders
- Helicobacter pylori-related gastroenterology studies
- Clinical Laboratory Practices and Quality Control
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adrenal and Paraganglionic Tumors
- Eosinophilic Esophagitis
- SARS-CoV-2 and COVID-19 Research
- Microscopic Colitis
- Soft tissue tumor case studies
- Viral gastroenteritis research and epidemiology
Shariati Hospital
2016-2025
Tehran University of Medical Sciences
2016-2025
Mazandaran University of Medical Sciences
2007-2021
Jahrom University of Medical Sciences
2021
Imam Khomeini Hospital
2014-2020
Hospital Fatuma Bourguiba Monastir
2008-2015
University of Monastir
2006-2013
University of Tehran
2013
University of Sousse
1983
University Medical Center Freiburg
1964
Background: According to official data, 60-70% of clinical decisions about hospitalization and discharge are based on laboratory results. Aims: The objective this study is examine the frequency errors before, during, after analysis in a major medical laboratory. Materials Methods: This descriptive, cross-sectional was conducted throughout 2012 (January-December 2012). Errors recorded by Quality Control Committee specially designed record. Results: A total 303,866 samples, 2,430,928 tests...
Background & Objective Angiogenesis is an essential component of tumor growth.Expression PSMA on the neo-vasculature many solid tumors, including glioblastoma multi-form, has been determined.The pattern expression suggests that may play a functional role in angiogenesis.Methods: different grades brain glioma was evaluated by immunohistochemistry method to determine probable usefulness anti-PSMA antibody as complementary target therapy glioma.Results: Overall, 72 cases low (grade I and II)...
The long-term duration of cell-mediated immunity induced by neonatal hepatitis B virus (HBV) vaccination is unknown.Study was designed to determine the cellular memory status among young adults twenty years after infantile HB immunization.Study subjects were party selected from a recent seroepidemiologic study in adults, who had been vaccinated against HBV earlier. Just before and ten 14 days one dose vaccine booster injection, blood samples obtained sera concentration cytokines (interleukin...
The seroprevalence of hepatitis E virus infection (HEV) in children and young adults was determined a community-based survey an area northern Islamic Republic Iran. Serum samples were taken from 1080 randomly selected apparently healthy 2-25-year-olds urban rural regions Sari district. Anti-HEV IgG antibodies detected 25 individuals (2.3%). Seroprevalence increased significantly with age 3/255 (1.2%) < 10 years to 8/110 (7.3%) those aged 20-25 years. No differences HEV status noted between...
Definite diagnosis of follicular thyroid carcinoma (FTC) is based on the presence capsular or vascular invasion. To date, no reliable and practical method has been introduced to discriminate this malignant neoplasm from adenoma (FTA) in fine needle aspiration biopsy material. Matrix metalloproteinase-2 (MMP-2), by degrading extracellular matrix, caspase-3, induction apoptosis, have shown play important roles carcinogenesis aggressive behavior many tumor types. The aim study was examine...
The epidemiological impact and the duration of protection provided by infant hepatitis B (HB) vaccination are unknown.This study was designed to determine virus (HBV) infection seromarkers in young adults who have been vaccinated against HBV as first group Iranian neonates during 1993 1994.We recruited 510 with a history complete HB at birth. (HB surface antigen (HBs Ag), antibody HBs Ag (Anti-HBs), core (Anti-HBc) were measured using ELISA method. Anti-HBs titers ≥ 10 IU/L considered...
Transformation of a normal cell to cancerous one is dependent on the accumulation several genetic and epigenetic alterations. One candidate driver alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, SDHAF2. The most important SDH mutation SDHD gene, which encodes smallest subunit mitochondrial complex II (SDH). It has key function both familial non-familial hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC). SDHx genes mutations...
Introduction : Acinetobacter species in clinical isolates cause severe infections including meningitis, bloodstream infection, ventilator-associated pneumonia, and surgical site infections. Objectives In the present study, we evaluated drug resistance using both European Committee on Antimicrobial Susceptibility Testing (EUCAST) Clinical Laboratory Standards Institute (CLSI) antimicrobial susceptibility test methods. Materials Methods: specimens of 128 patients who were admitted three...
Currently, the only reliable indicator of malignancy in pheochromocytoma is presence distant metastasis or extensive local invasion; predicting behavior remains challenging. We aimed to correlate with its expression nm-23, cyclooxygenase (COX)-2, and galectin-3 (genes used predict course some neoplastic diseases), evaluated immunohistochemically 55 paraffin blocks formalin-fixed specimens confirmed behavior. In 3 (7%) 44 benign 7 (64%) 11 malignant pheochromocytomas, there was negative nm-23...
Abstract Papillary thyroid cancer (PTC) is the most common type of among malignancies. Tumor‐related methylation circulating tumor DNA (ctDNA) in plasma could represent specific alterations can be considered as good biomarkers cells. In this study, we studied status seven promoter regions two methyl Transferases (MGMT and DNMT1) genes methylated ctDNA tissue samples patients with PTC goiter noncancerous controls. Methods: Both genomic 57 45 Goiter were isolated. After bisulfite modification,...
Tumor-associated macrophages (TAMs) residing in the tumor microenvironment (TME) are characterized by their pivotal roles progression, antitumor immunity, and TME remodeling. However, a thorough comparative characterization of tumor-TAM crosstalk across IDH-defined categories glioma remains elusive, likely contributing to mixed outcomes clinical trials. We delineated phenotypic heterogeneity TAMs IDH-stratified gliomas. Notably, two TAM subsets with mesenchymal phenotype were enriched IDH-WT...
Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of malignancies. Epigenetic alteration, in which chromatin conformation and gene expression change without changing sequence DNA, can occur some tumor suppressor genes oncogenes. Methylation epigenetic alterations that an excellent indicator PTC invasive behavior. Methods: In this research, we determined promoter methylation status four (SLC5A8, RASSF1, MGMT, DNMT1) compared results 55 cases...
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease (IBD) that progressively affects mucosa and submuccosa of the colon rectum in continual pattern. In comparison, Crohn (CD), other type IBD, transmural disorder can involve any part gastrointestinal tract. MR enterography (MRE) has emerged as an important imaging modality for diagnosis detection activity complications CD, with comparable results to those endoscopy. But MRE been underused assessment UC recent years,...
Background: AmpC β-lactamase confers resistance to a variety of β-lactam agents, and all plasmid-mediated genes are considered clinically significant. The transfer the gene plasmid has resulted in dissemination among Enterobacteriaceae family, including Escherichia coli, Klebsiella spp., Proteus mirabilis. Objectives: prevalence was determined isolates E. P. mirabilis with reduced susceptibility cefoxitin or extended-spectrum cephalosporins by multiplex PCR method. Methods: A total 310...
Abstract Background hepatitis B virus (HBV) and C (HCV) are among the leading causes of mortality worldwide. Health care personnel (HCP) subjected to increased risk these infections. Therefore, HBV vaccination post-vaccination serologic testing (PVST) recommended for them. Our objectives in this study were investigate how well guidelines hospital HCP s implemented. Moreover, prevalence rates HCV infections calculated. To determine presence immunological memory, vaccinated negative antibody...
The policy of administering the second dose measles-mumps-rubella (MMR) vaccine (MMR(2)) has recently changed in Iran, at age 1.5 years instead 4-6 previously. effects such a change on immune status individual are evaluated this study.Totally 249 and 228 children aged 18 months 4- to 6-year-olds, respectively, with documented receipt primary MMR ≥ 1 year were enrolled. Before, weeks after MMR(2) administration, anti-MMR IgG antibody levels measured using ELISA method. IgM also assessed...
Abstract Background Despite high rate of vaccination coverage with 2-doses measles containing vaccine among Iranian children, outbreaks occurred different age groups and fully vaccinated subjects. Although the main reason for these is unknown, however, failure was supposed to be an important cause. This study designed determine seroconversion rates measles- mumps- rubella (MMR) currently in use children. Methods prospective conducted healthy children older than 12 months who were candidates...
ABSTRACT Tumor-associated macrophages (TAMs) residing in the tumor microenvironment (TME) are characterized by their pivotal roles progression, antitumor immunity, and TME remodeling. However, a thorough comparative characterization of tumor-TAM crosstalk across IDH-defined categories glioma remains elusive. We delineated phenotypic heterogeneity TAMs IDH-stratified gliomas. Notably, two TAM subsets with mesenchymal phenotype were enriched IDH-WT glioblastoma (GBM) correlated poorer patient...
The emerge of rapid and accurate detection Meticillin-Resistant Staphylococcus aureus (MRSA) has been highlighted.The current study evaluated the prevalence mec-A gene in biological specimens various medical wards, order to determine any possible relationship.Using traditional culture methods, 250 isolates were detected. mediated resistance was by PCR method.Among 98 (39.2%) with resistant inhibition zones, 92 carried considered as MRSA. Significantly higher rate MRSA observed from emergency...