A5014688092- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Renal Transplantation Outcomes and Treatments
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Pediatric Urology and Nephrology Studies
- Organ Transplantation Techniques and Outcomes
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Treatment and Research
- Advanced biosensing and bioanalysis techniques
- Folate and B Vitamins Research
- Cancer Cells and Metastasis
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Transplantation: Methods and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Renal and related cancers
- Neonatal Health and Biochemistry
- Urinary Bladder and Prostate Research
- BRCA gene mutations in cancer
Tehran University of Medical Sciences
2015-2025
Sina Hospital
2020-2024
University of Washington
2024
Institute for Health Metrics and Evaluation
2024
Imam Khomeini Hospital
2024
Damghan University
2023
Ahvaz Jundishapur University of Medical Sciences
2018
Iranshahr University
2018
Shahid Beheshti University of Medical Sciences
2007-2016
Boston University
2016
Visual one-step simultaneous detection of low-abundance methylation is a crucial challenge in early cancer diagnosis simple manner. Through the design closed split bipolar electrochemistry system (BE), promoter tumor suppressor genes papillary thyroid cancer, RASSF1A and SLC5A8, was achieved using electrochemiluminescence. For this purpose, electrochemiluminescence luminol loaded into Fe3O4@UiO-66 gold nanorod-functionalized graphite-like carbon nitride nanosheet (AuNRs@C3N4 NS), separately,...
Standard enzyme-linked immunosorbent assays based on microplates are frequently utilized for various molecular sensing, disease screening, and nanomedicine applications. Comparing this multi-well plate batched analysis to non-batched or non-standard testing, the diagnosis expenses per patient drastically reduced. However, requirement rather big pricey readout instruments prevents their application in environments with limited resources, especially field. In work, a handheld cellphone-based...
Abstract Background Urinary tract cancers including bladder, kidney, ureter, and pelvis are a common malignancy worldwide with high mortality ratio. Aimed to investigate the prevalence of these cancers, we conducted this study. Methods In study, all information related ICD10 codes, gender, age province residence individuals were obtained from data Iran’s cancer registry by Ministry Health, Medicine Medical Education demographic evidence for each sub-country reports Statistics Center Iran...
Digital microfluidics (DMF) is revolutionizing point-of-care diagnostics by advancing lab-on-a-chip technology. To accelerate translation to real-life applications, it crucial devise rapid and low-cost methods for prototyping test various design ideas. Here, we present one such method using an unmodified desktop inkjet printer inexpensive materials. Inkjet-printing eliminates the need costly printed circuit board technology or microfabrication facilities, significantly lowering barriers...
Introduction: Renal cell cancer (RCC) syndrome is linked to Krebs cycle compartments and their coding genes' alterations like succinate dehydrogenase genes ( SDHx ). Here we present a systematic review of the SDH mutations impact on both RCC diagnosis prognosis. Methods: This includes any study in which tissue samples are considered correlation with mutations, microsatellite instability (MSI), protein expression. For this purpose, search MEDLINE (PubMed), Scopus, Embase, Web Science...
We aimed to explain the role of mesenchymal stem cells (MSC-exosomes) on gene expressions epithelial transition (EMT), angiogenesis, and apoptosis. Four different cell lines were employed, including ACHN, 5637, LNCaP, PC3, as well-known representatives for renal, bladder, hormone-sensitive, hormone-refractory prostate cancers, respectively. Cell exposed diverse concentrations cells-derived exosomes find IC50 values. Percentages apoptotic evaluated by Annexin/P.I. staining. Micro Culture...
Abstract Background Several factors such as recipient age, BMI, serum cratinine, and positive history of dialysis are important in predicting graft survival among kidney transplant recipients. One factor affecting the outcomes is donors recipients gender, which usually ignored. Methods A total 1113 were studied this retrospective cohort study. taken into account for gender age addition to common like eGFR, dialysis. Results The most successful based on donor-recipient was observed male donor...
Abstract Circulating cell‐free DNA (cfDNA) has been considered as a diagnostic source to track genetic and epigenetic alterations in cancer. We aimed study mutation addition the methylation status promoter regions of RASSF1 SLC5A8 genes tissues circulating free samples patients affected with papillary thyroid carcinoma (PTC) nodules controls. BRAF V600E was studied by ARMS‐scorpion real‐time polymerase chain reaction method 57 PTC 45 nodule cases. Methylation analyzed methylation‐specific...
Particle separation and sorting techniques based on microfluidics have found extensive applications are increasingly gaining prominence. This research presents the design fabrication of a microfluidic device for separating cells using deterministic lateral displacement (DLD), enabling accuracy continuity while being size-based. Nevertheless, it remains demanding, to completely reverse detrimental effects boundaries that disturb fluidic flow in channel reduce particle efficiency. study...
Objectives We aimed to evaluate the association of nutritional status and health-related quality life (HRQOL) among elderly Iranian residents. Methods used 36-item Short Form Health Survey (SF-36) assess HRQOL participants with normal nutrition status, at risk malnutrition, malnourished. Results Mean group scores for Physical Component Summary (PCS) SF-36 were 44, 36.5, 29.0 normal, at-risk, malnourished groups, respectively; Mental (MCS), these 47.1, 40.7, 34.8, respectively. The PCS MCS...
Despite the loss of Adenomatous Polyposis Coli (APC) in a majority colorectal cancers (CRC), not all CRCs bear hallmarks Wnt activation, such as nuclear β-catenin. This underscores presence other regulators that are important to define, given pathogenic and prognostic roles β-catenin human CRC. Herein, we investigated effect Casitas B-lineage lymphoma (c-Cbl) on β-catenin, which is an oncoprotein upregulated CRC due loss-of-function APC or gain-of-function CTNNB1 mutations. mechanistic...
Transformation of a normal cell to cancerous one is dependent on the accumulation several genetic and epigenetic alterations. One candidate driver alterations can happen in succinate dehydrogenases (SDHx) coding gene include SDHA, SDHB, SDHC, SDHD, SDHAF2. The most important SDH mutation SDHD gene, which encodes smallest subunit mitochondrial complex II (SDH). It has key function both familial non-familial hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC). SDHx genes mutations...