A5050700218- Angiogenesis and VEGF in Cancer
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- SARS-CoV-2 and COVID-19 Research
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- Fibroblast Growth Factor Research
- Hippo pathway signaling and YAP/TAZ
- Retinal Diseases and Treatments
- Axon Guidance and Neuronal Signaling
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Microtubule and mitosis dynamics
- Growth Hormone and Insulin-like Growth Factors
- 14-3-3 protein interactions
- Protein Tyrosine Phosphatases
Hormozgan University of Medical Sciences
2025
Boston University
2015-2024
Shiraz University of Medical Sciences
2024
Universiti Teknologi MARA
2012-2024
Boston Medical Center
2011-2022
Emory University Hospital
2021
Yasuj University of Medical Sciences
2021
University School
2015
Virginia Tech
2003
Massachusetts Eye and Ear Infirmary
1999
As the COVID-19 pandemic continues to spread, investigating processes underlying interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report identification CD209L/L-SIGN related protein CD209/DC-SIGN as receptors capable mediating entry into human cells. Immunofluorescence staining tissues revealed prominent expression CD209L in lung kidney epithelia endothelia. Multiple biochemical assays using a purified recombinant spike receptor-binding domain (S-RBD) or S1...
SARS-CoV-2 entry into host cells is a crucial step for virus tropism, transmission, and pathogenesis. Angiotensin-converting enzyme 2 (ACE2) has been identified as the primary receptor SARS-CoV-2; however, possible involvement of other cellular components in viral not yet fully elucidated. Here we describe identification vimentin (VIM), an intermediate filament protein widely expressed mesenchymal origin, important attachment factor on human endothelial cells. Using liquid...
Previous studies have shown that the adaptor protein Shb is involved in receptor tyrosine kinase signaling. In this study, we demonstrate phosphorylated an Src-dependent manner upon vascular endothelial growth factor (VEGF) stimulation using porcine aortic cells expressing human VEGF 2 (VEGFR-2) (KDR). co-immunoprecipitation experiments, could detect interaction between and VEGFR-2 telomerase-immortalized microvascular cells. Furthermore, a glutathione S-transferase pull-down assay, Src...
Abstract As the COVID-19 pandemic continues to spread, investigating processes underlying interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report identification CD209L/L-SIGN related protein CD209/DC-SIGN as receptors capable mediating entry into human cells. Immunofluorescence staining tissues revealed prominent expression CD209L in lung kidney epithelium endothelium. Multiple biochemical assays using a purified recombinant spike receptor binding domain (S-RBD)...
Activation of vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in vasculogenesis and angiogenesis. However, the mechanism by which VEGFR-2 activation elicits these cellular events is not fully understood. We recently constructed chimeric receptor containing extracellular domain human CSF-1R/c-fms, fused with entire transmembrane cytoplasmic domains murine (Rahimi, N., Dayanir, V., Lashkari, K. (2000) J. Biol. Chem. 275, 16986–16992). In this study we used chimera...
Overexpression and amplification of hepatocyte growth factor (HGF) receptor (Met) have been detected in many types human cancers, suggesting a critical role for Met development malignant cells. However, the molecular mechanism by which contributes to tumorigenesis is not well known. The tyrosine kinase c-Src has implicated as modulator cell proliferation, spreading, migration; these functions are also regulated Met. To explore whether involved HGF-induced growth, mouse mammary carcinoma line...
The internalization and degradation of vascular endothelial growth factor receptor 2 (VEGFR-2), a potent angiogenic tyrosine kinase, is central mechanism for the regulation coordinated action VEGF in angiogenesis. Here, we show that VEGFR-2 ubiquitinated response to VEGF, Lys 48-linked polyubiquitination controls its via 26S proteosome. ubiquitination controlled by PEST domain, phosphorylation Ser1188/Ser1191 required VEGFR-2. F-box-containing β-Trcp1 ubiquitin E3 ligase recruited...
Abstract Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC). Despite its high expression in immune cells, the effect c-Cbl on tumor microenvironment remains poorly understood. Here we demonstrate that alters suppresses Programmed cell death-1 (PD-1) protein, checkpoint receptor. Using syngeneic CRC xenografts, observed significantly higher growth xenografts infiltrating cells +/− compared to +/+ mice. Tumor-associated CD8+ T-lymphocytes...
Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular damage, their role PAD remains elusive. Here, we show that the dietary tryptophan-derived uremic including indoxyl sulfate (IS) kynurenine (Kyn) at concentrations corresponding to those suppress β-catenin several cell types, microvascular endothelial cells (ECs), inhibiting Wnt activity proangiogenic targets ECs. Mechanistic...
Stromal cells can dramatically affect the growth and metastatic capability of breast carcinoma cells. Growth factors, considered to be important mediators this process, act as either mitogenic or mito-inhibitory regulators. We have developed an in vitro coculture system examine influence adipocytes, a dominant mammary stromal cell type, on murine carcinoma, SP1. Previously, we reported that conditioned medium (CM) from 3T3-L1 adipocytes promote SP1 now show major signal derived adipocyte CM...
Background Vascular endothelial growth factor receptor-2 (VEGFR-2) signaling is an obligate requirement for normal development and pathological angiogenesis such as cancer age-related macular degeneration. Although autophosphorylation of tyrosine 1173 (Y1173) VEGFR-2 considered a focal point its angiogenic signal relay, however, the mechanism phosphorylation Y1173, proteins that are recruited to this residue their role in not fully understood. Methodology/Principal Findings In study we...
Vascular endothelial growth factor receptor-1/fms-related tyrosine kinase 1 (VEGFR-1/FLT1) is expressed as a membrane-bound receptor and an alternatively spliced soluble protein (sVEGFR-1) containing the 1-6 IgG-like domain of its ectodomain. sVEGFR-1 known naturally occurring inhibitor angiogenesis surrogate marker for cancer progression; it also linked to pregnancy-induced hypertension called preeclampsia avascularity normal cornea. It remains open question whether alternative mRNA...
Angiogenesis—the growth of new blood vessels from preexisting vessels—is an important physiological process and is considered to play a key role in tumor metastasis. We identified the immunoglobulin-containing proline-rich receptor-1 (IGPR-1, also called TMIGD2) gene as novel cell adhesion receptor that expressed various human organs tissues, mainly cells with epithelium endothelium origins. IGPR-1 regulates cellular morphology, homophilic aggregation, cell–cell interaction. activity...