A5103173660- Microtubule and mitosis dynamics
- Neurofibromatosis and Schwannoma Cases
- Multiple Myeloma Research and Treatments
- Ubiquitin and proteasome pathways
- SARS-CoV-2 and COVID-19 Research
- Cellular transport and secretion
- COVID-19 Clinical Research Studies
- Glycosylation and Glycoproteins Research
- Hippo pathway signaling and YAP/TAZ
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
Boston Medical Center
2020-2022
Boston University
2020-2022
As the COVID-19 pandemic continues to spread, investigating processes underlying interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report identification CD209L/L-SIGN related protein CD209/DC-SIGN as receptors capable mediating entry into human cells. Immunofluorescence staining tissues revealed prominent expression CD209L in lung kidney epithelia endothelia. Multiple biochemical assays using a purified recombinant spike receptor-binding domain (S-RBD) or S1...
Abstract As the COVID-19 pandemic continues to spread, investigating processes underlying interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report identification CD209L/L-SIGN related protein CD209/DC-SIGN as receptors capable mediating entry into human cells. Immunofluorescence staining tissues revealed prominent expression CD209L in lung kidney epithelium endothelium. Multiple biochemical assays using a purified recombinant spike receptor binding domain (S-RBD)...
The cell adhesion molecule IGPR-1 regulates various critical cellular processes including, cell-cell adhesion, mechanosensing and autophagy plays important roles in angiogenesis tumor growth; however, the molecular mechanism governing surface levels of remains unknown.In present study, we used an vitro ubiquitination assay identified ubiquitin E3 ligase NEDD4 conjugating enzyme UbcH6 involved IGPR-1. In GST-pulldown vivo co-immunoprecipitation assays demonstrated that binds to...
Abstract Background The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell–cell adhesion, proliferation cycle. However, the mechanisms of TMIGD1 signaling are not yet fully elucidated. Results binds to ERM family proteins moesin ezrin, an evolutionarily conserved RRKK motif on carboxyl terminus mediates interaction with N-terminal domains ezrin. governs apical localization as loss...
Through tightly controlled multilayer mechanisms, vascular endothelial growth factor receptor-2 (VEGFR-2) activation and its downstream signal transduction govern vasculogenesis pathological angiogenesis, such as tumor angiogenesis. Therefore, it is critical to understand the molecular mechanisms governing VEGFR-2 transduction. We report that protein arginine methyltransferase 4 (PRMT4) via highly conserved EVH1 PH domain-like N-terminal domain binds mediates methylation of juxtamembrane 817...
ABSTRACT Background The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating cell-cell adhesion, proliferation cycle. However, the mechanisms of TMIGD1 signaling are not yet fully elucidated. Results binds to ERM family proteins moesin ezrin, an evolutionarily conserved RRKK motif on carboxyl terminus mediates interaction with N-terminal domains ezrin. governs apical localization as loss...
ABSTRACT The cell adhesion molecule immunoglobulin and proline-rich receptor-1 (IGPR-1) regulates various critical cellular processes including, cell-cell adhesion, mechanosensing autophagy. However, the molecular mechanisms governing IGPR-1 surface expression levels remains unknown. In present study, we used an in vitro ubiquitination assay identified ubiquitin E3 ligase NEDD4 conjugating enzyme UbcH6 involved of IGPR-1. GST-pulldown vivo co-immunoprecipitation assays demonstrated that...