A5100711945- Pulmonary Hypertension Research and Treatments
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Colorectal Cancer Treatments and Studies
- Cancer-related gene regulation
- Cardiovascular Issues in Pregnancy
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Bone Tumor Diagnosis and Treatments
- Vascular Anomalies and Treatments
- Gastric Cancer Management and Outcomes
- Cardiovascular Function and Risk Factors
- Oral and Maxillofacial Pathology
- Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cancer Cells and Metastasis
- Renal Transplantation Outcomes and Treatments
- HER2/EGFR in Cancer Research
- Ultrasound in Clinical Applications
- Colorectal Cancer Screening and Detection
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- SARS-CoV-2 and COVID-19 Research
Boston University
2014-2025
Affiliated Hospital of Hebei University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Fu Wai Hospital
2023-2024
Beijing Anzhen Hospital
2023
Capital Medical University
2023
Boston Medical Center
2015-2022
University Medical Center
2015-2022
Chinese PLA General Hospital
2022
Henan University Huaihe Hospital and Huaihe Clinical Institute
2021-2022
As the COVID-19 pandemic continues to spread, investigating processes underlying interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report identification CD209L/L-SIGN related protein CD209/DC-SIGN as receptors capable mediating entry into human cells. Immunofluorescence staining tissues revealed prominent expression CD209L in lung kidney epithelia endothelia. Multiple biochemical assays using a purified recombinant spike receptor-binding domain (S-RBD) or S1...
Abstract As the COVID-19 pandemic continues to spread, investigating processes underlying interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report identification CD209L/L-SIGN related protein CD209/DC-SIGN as receptors capable mediating entry into human cells. Immunofluorescence staining tissues revealed prominent expression CD209L in lung kidney epithelium endothelium. Multiple biochemical assays using a purified recombinant spike receptor binding domain (S-RBD)...
Mucin 1 (MUC1) is a heterodimeric protein that aberrantly overexpressed on the surface of diverse human carcinomas and an attractive target for development mAb-based therapeutics. However, attempts at targeting shed MUC1 N-terminal subunit have been unsuccessful. We report here generation mAb 3D1 against nonshed oncogenic C-terminal (MUC1-C) subunit. show binds with low nM affinity to MUC1-C extracellular domain restricted α3 helix. reactivity selective MUC1-C-expressing cancer cell lines...
Introduction: Mounting evidence indicates a possible connection between the systemic inflammatory response index (SIRI) and prognosis of heart failure, but its role in idiopathic pulmonary arterial hypertension (IPAH) is not well understood. This study aimed to investigate relationship SIRI variables such as functional ability, echocardiography results, hemodynamic measurements, long-term outcomes patients with IPAH. Methods: The included 426 consecutive IPAH who underwent right...
Abstract Background Insulin resistance (IR) plays an important role in the pathophysiology of cardiovascular disease. Recent studies have shown that diabetes mellitus and impaired lipid metabolism are associated with severity prognosis idiopathic pulmonary arterial hypertension (IPAH). However, relationship between IR is poorly understood. This study explored association four indices IPAH using data from a multicenter cohort. Methods A total 602 consecutive participants were included this...
Malignant biphasic tumor also known as carcinosarcoma is an uncommon neoplasm that composed of both malignant epithelial and mesenchymal components. Most reported cases affect the female genital tract; however, other sites including head neck, lung, breast have been described. Carcinosarcoma thyroid extremely rare aggressive malignancy with ominous clinical course similar to anaplastic carcinoma.We report a case 45-year-old who was found carcinosarcoma. Her declined significantly shortly...
The coexistence of two different malignancies in one site is rare. Development renal cell carcinoma (RCC) and lymphoma the same individual speculated to be due common immune mechanism and/or genetic predisposition. We report a tumor comprising RCC localized primary diffuse large B-cell (DLBCL) native kidney 53-year-old transplant recipient after 15 years transplant. Patient had stable function on tacrolimus, mycophenolate mofetil (MMF) prednisolone. On trauma pan scan (as he reported an...
Despite the loss of Adenomatous Polyposis Coli (APC) in a majority colorectal cancers (CRC), not all CRCs bear hallmarks Wnt activation, such as nuclear β-catenin. This underscores presence other regulators that are important to define, given pathogenic and prognostic roles β-catenin human CRC. Herein, we investigated effect Casitas B-lineage lymphoma (c-Cbl) on β-catenin, which is an oncoprotein upregulated CRC due loss-of-function APC or gain-of-function CTNNB1 mutations. mechanistic...
Abstract Background A subset of COVID-19 patients exhibit clinical features cytokine storm. However, clinicopathologic diagnostic hemophagocytic lymphohistiocytosis (HLH) have not been reported. Pathologic studies to date largely focused on the pulmonary finding diffuse alveolar damage (DAD). To this aim, we study reticuloendothelial organs four consecutive dying and correlate with laboratory parameters detect HLH. Methods Autopsies restricted chest abdomen were performed who succumbed...
Objectives/Hypothesis To evaluate the usefulness of elastic scattering spectroscopy (ESS) as a diagnostic adjunct to frozen section analysis in patients with diagnosed squamous cell carcinoma oral cavity. Study Design Prospective analytic study. Methods Subjects for this single institution, institutional review board–approved study were recruited from among undergoing surgical resection cancer A portable ESS device contact fiberoptic probe was used obtain spectral signals. Four 10 readings...
Abstract Purpose: Sessile serrated lesions (SSL) are precursors to colon carcinoma, and their distinction from other polyps, in particular hyperplastic polyps (HP), presents significant diagnostic challenges. We evaluated expression patterns colonic of previously identified carcinoma–associated extracellular matrix (ECM) proteins identify markers distinguishing SSLs polyps. Experimental Design: Gene-expression analyses ECM were performed using publicly available data on preneoplastic In...
To date, the efficacy of glucocorticoid therapy to reduce mortality in patients with acute respiratory distress syndrome (ARDS) has remained controversial among studies available. The present meta-analysis study aimed further clarify impact on ARDS by performing a pooled analysis previous data. PubMed, Chinese Knowledge Infrastructure, Wanfang and Cochrane trials databases were searched for relevant published between 1966 2016. Randomized controlled (RCTs) that included use glucocorticoids...