A5101475002- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Genital Health and Disease
- Autoimmune and Inflammatory Disorders Research
- Urological Disorders and Treatments
- Medical Imaging and Pathology Studies
- Breast Cancer Treatment Studies
- Hemoglobinopathies and Related Disorders
- Breast Lesions and Carcinomas
- Urologic and reproductive health conditions
- MRI in cancer diagnosis
- COVID-19 Clinical Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Thyroid Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Thyroid Cancer Diagnosis and Treatment
- Dermatological and COVID-19 studies
- Immune cells in cancer
- Metastasis and carcinoma case studies
- Kawasaki Disease and Coronary Complications
- Long-Term Effects of COVID-19
- Parathyroid Disorders and Treatments
- Erythrocyte Function and Pathophysiology
Boston Medical Center
2018-2023
Boston University
2018-2023
Burlington College
2020
University Medical Center
2018
Abstract Objectives A subset of coronavirus disease 2019 (COVID-19) patients exhibit clinical features cytokine storm. However, clinicopathologic diagnostic hemophagocytic lymphohistiocytosis (HLH) have not been reported. We studied the reticuloendothelial organs 4 consecutive who died COVID-19 and correlated with laboratory parameters to detect HLH. Methods Autopsies were performed on COVID-19. Routine H&E staining immunohistochemical for CD163 hemophagocytosis. Clinical results from...
Abstract Background A subset of COVID-19 patients exhibit clinical features cytokine storm. However, clinicopathologic diagnostic hemophagocytic lymphohistiocytosis (HLH) have not been reported. Pathologic studies to date largely focused on the pulmonary finding diffuse alveolar damage (DAD). To this aim, we study reticuloendothelial organs four consecutive dying and correlate with laboratory parameters detect HLH. Methods Autopsies restricted chest abdomen were performed who succumbed...
Breast imaging radiologists regularly perform image-guided biopsies of suspicious breast lesions based on features that are associated with a likelihood malignancy ranging from 2% to greater than 95% (Breast Imaging Reporting and Data System categories 4 5). As diagnostic partners, pathologists histopathologic assessment these tissue samples confirm diagnosis. Correlating the findings results is an integral aspect multidisciplinary care. Assessment radiologic-pathologic concordance vital in...
Purpose To better understand the pathophysiology of lichen sclerosus (LS) urethral stricture disease (USD), we aimed to investigate expression profiles microRNAs (miRNAs) in tissue samples from men undergoing urethroplasty. Methods Urethral was collected 2005–2020. Histologic features diagnostic LS were basis pathologic evaluation. Foci areas for or non-LS strictures chosen RNA In an initial screening analysis, 13 and profiled via miRNA RT-qPCR arrays 752 unique miRNA. A validation analysis...
INTRODUCTION AND OBJECTIVE: The pathophysiology of Lichen Sclerosus (LS) urethral stricture disease (USD) is poorly understood. MicroRNA (miRNA) are non-coding genetic material involved in the regulation gene expression. We sought to examine LS and non-LS USD by comparing miRNA expression profiles men undergoing urethroplasty. METHODS: Total RNA was extracted from formalin-fixed, paraffin-embedded tissue samples 13 strictures collected 2005-2017. pathologic evaluation based on histologic...
: Lung cancer is the most common cause of death worldwide. While targeted therapies have offered promise for a small subset patients with driver mutations, usually found among light/never-smokers, majority arise heavy smokers are not benefited. Immune checkpoint inhibition has instead greater in this larger cohort patients. This observation led to attention immune components tumor microenvironment (TME) and model immunoediting emerged which evolves through phases elimination, equilibrium,...
GLIS3 is a transcription factor indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation. Likewise, PAX8 regulates the expression of genes encoding thyroglobulin, peroxidase, sodium-iodide symporter. Mutations either or have been associated with congenital hypothyroidism. Hyalinizing trabecular tumor gland peculiar variant cell–derived neoplasms, which shows characteristic arrangement prominent hyaline feature. This entity has traditionally linked...