A5084599496- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Muscle Physiology and Disorders
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Adipose Tissue and Metabolism
- Cardiovascular Health and Disease Prevention
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Fatty Acid Research and Health
- Clinical Nutrition and Gastroenterology
- Cardiovascular and exercise physiology
- Tea Polyphenols and Effects
- RNA and protein synthesis mechanisms
- Cardiovascular Disease and Adiposity
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Exercise and Physiological Responses
- Nutritional Studies and Diet
- Curcumin's Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Enzyme Catalysis and Immobilization
- Genomics and Chromatin Dynamics
Universidade Estadual de Campinas (UNICAMP)
2025
Abbott (United States)
2015-2024
Abbott Nutrition (United States)
2015-2024
Australian Institute for Musculoskeletal Science
2024
Western Health
2024
The University of Melbourne
2024
Abbott (Canada)
2020-2021
Nutrition 21 (United States)
2020
Ross Laboratories (United States)
2003-2020
Discovery Laboratories (United States)
2013-2017
OBJECTIVES To develop an evidence‐based definition of sarcopenia that can facilitate identification older adults at risk for clinically relevant outcomes (eg, self‐reported mobility limitation, falls, fractures, and mortality), the Sarcopenia Definition Outcomes Consortium (SDOC) crafted a set position statements informed by literature review SDOC's analyses eight epidemiologic studies, six randomized clinical trials, four cohort studies special populations, two nationally representative...
ackground: Sarcopenia is characterized by progressive loss of muscle mass with corresponding decline in strength and/or physical function. The economic burden sarcopenia-associated disability considerable the US. Objective: To estimate cost hospitalizations US adults sarcopenia categorized age, sex, and race/ethnicity. Design, setting participants: A retrospective, prevalence based, study, consisting 4011 aged ≥40 years without sarcopenia. Methods: Data on low lean mass, functional...
Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on definition exists. The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing global conceptual sarcopenia. GLIS steering committee was formed 2019-21 with representatives from all relevant scientific societies worldwide. During time, developed a set statements topic invited members these participate two-phase...
Recent evidence suggests that nutritional interventions may improve muscle outcomes in malnutrition and sarcopenia.We evaluated the effects of 2 high-quality oral supplements (ONS) differing amount type key nutrients older adult men women.A multicenter, randomized, double-blinded, controlled clinical trial.Malnourished sarcopenic women, 65 years (n = 330).A 24-week intervention period with energy-rich (330 kcal) ONS treatment groups: Control (CONS, 14 g protein; 147 IU vitamin D3) versus...
β-Hydroxy-β-methylbutyrate (HMB) is a leucine metabolite shown to reduce protein catabolism in disease states and promote skeletal muscle hypertrophy response loading exercise. In this study, we evaluated the efficacy of HMB wasting recovery following disuse aged animals. Fisher 344×Brown Norway rats, 34 mo age, were randomly assigned receive either Ca-HMB (340 mg/kg body wt) or water vehicle by gavage ( n = 32/group). The animals received 14 days hindlimb suspension (HS, 8/diet group)...
Abstract Background Lack of consensus on how to diagnose sarcopenia has limited the ability this condition and hindered drug development. The Sarcopenia Definitions Outcomes Consortium (SDOC) was formed develop evidence-based diagnostic cut points for lean mass and/or muscle strength that identify people at increased risk mobility disability. We describe here proceedings a meeting SDOC other experts discuss strategic considerations in development definition. Methods Presentations panel...
Archaea contain histones that have primary sequences in common with eukaryal nucleosome core and a three-dimensional structure is essentially only the histone fold. Here we report results of experiments document archaeal compact DNA vivo into structures similar to formed by (H3+H4) 2 tetramer at center nucleosome. After formaldehyde cross-linking , these nucleosomes been isolated from Methanobacterium thermoautotrophicum Methanothermus fervidus visualized electron microscopy on plasmid...
In this study we tested the hypothesis that green tea extract (GTE) would improve muscle recovery after reloading following disuse. Aged (32 mo) Fischer 344 Brown Norway rats were randomly assigned to receive either 14 days of hindlimb suspension (HLS) or HLS followed by normal ambulatory function for (recovery). Additional animals served as cage controls. The given GTE (50 mg/kg body wt) water (vehicle) gavage 7 before and throughout experimental periods. Compared with vehicle treatment,...
Loss of muscle mass during periods disuse likely has negative health consequences for older adults. We have previously shown that β-hydroxy-β-methylbutyrate (HMB) supplementation 10 days strict bed rest (BR) attenuates the loss lean in To elucidate potential molecular mechanisms HMB effects on BR and resistance training rehabilitation (RT), we examined mediators skeletal mitochondrial dynamics, autophagy atrophy, intramyocellular lipids. Nineteen adults (60-76 yr) completed followed by 8-wk...
Sarcopenia is the natural age-associated loss of muscle mass/function, often occurring simultaneously with obesity, especially in older adults.Sarcopenia and obesity contribute to poor health outcomes when together as sarcopenic (SO) can cause further complications.Few studies have specifically considered these conditions across different racial/ethnic populations.This study examined prevalence sarcopenia SO among U.S. adults by age, sex, groups, using 1999-2004 data from National Health...
Diacylglycerol acyltransferase (DGAT) catalyses the last step in acyl-CoA-dependent triacylglycerol (TAG) biosynthesis and is an important determinant of cellular oil content quality. In this study, a gene, designated TaDGAT2, encoding type 2 DGAT (DGAT2)-related enzyme was identified from oleaginous marine protist Thraustochytrium aureum. The deduced TaDGAT2 sequence contains ~460 amino acid domain most closely related to DGAT2s Dictyostelium sp. (45-50% identity). Recombinant restored TAG...
Loss of muscle protein is a common feature wasting diseases where currently treatment limited. This study investigates the potential epigallocatechin-3-gallate (EGCg), most abundant catechin in green tea, to reverse increased degradation and rescue decreased synthesis which leads atrophy.Studies were conducted vitro using murine C2C12 myotubes. Increased reduced rates induced by serum starvation tumour necrosis factor-α (TNF-α).EGCg effectively attenuated depression increase myotubes at...
Mammalian skeletal muscles exhibit age-related adaptive and pathological remodeling. Several in particular undergo progressive atrophy degeneration beyond median lifespan. To better understand myocellular responses to aging, we used semi-quantitative global metabolomic profiling characterize trends metabolic changes between 15-month-old adult 32-month-old aged Fischer 344 × Brown Norway (FBN) male rats. The FBN rat gastrocnemius muscle exhibits age-dependent atrophy, whereas the soleus...
Background & aimsPoor nutritional status leads to multiple adverse outcomes, but few studies have assessed its role as a risk factor for incident frailty and death in community-dwelling older adults. Hence, the aim of this paper is assess using Global Leadership Initiative on Malnutrition (GLIM) criteria mortality Spanish adults.MethodsWe used data from two waves (waves 2 (2011–2013) 3 (2015–2017)) Toledo Study Healthy Ageing, which an observational, prospective cohort (average follow-up =...