A5065145388- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Circadian rhythm and melatonin
- Geological and Geophysical Studies
- RNA Interference and Gene Delivery
- Meteorological Phenomena and Simulations
- COVID-19 diagnosis using AI
- Cancer-related molecular mechanisms research
- Organoboron and organosilicon chemistry
- Soil Moisture and Remote Sensing
- Hydrocarbon exploration and reservoir analysis
- Precipitation Measurement and Analysis
- Circular RNAs in diseases
- Glycosylation and Glycoproteins Research
- Geochemistry and Geologic Mapping
- Genomics and Phylogenetic Studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
Southern University of Science and Technology
2020-2024
Jinan University
2021-2023
ShenZhen People’s Hospital
2023
Fujian Medical University
2022
Peking University
2017-2020
State Key Laboratory of Digital Medical Engineering
2007
Southeast University
2007
While 1,2-addition represents the most common mode of alkyne hydroboration, herein we describe a new 1,1-hydroboration mode. It is first demonstration gem-(H,B) addition to an triple bond. With superior [CpRu(MeCN)3]PF6 catalyst, range silyl alkynes reacted efficiently with HBpin under mild conditions form various synthetically useful vinyl boronates complete stereoselectivity and broad functional group compatibility. An extension germanyl hydrosilylation alkynyl toward same type products...
Abstract Motivation Many studies have shown that IDH mutation and 1p/19q co-deletion can serve as prognostic signatures of glioma. Although these genetic variations affect the expression one or more genes, value gene related to status is still unclear. Results We constructed an ensemble pair signature for risk evaluation survival prediction glioma based on prior knowledge status. First, we separately built two IDH-GPS 1p/19q-GPS elucidated they were useful transcriptome markers projecting...
Abstract N6-methyladenosine (m6A) RNA methylation is the predominant epigenetic modification for mRNAs that regulates various cancer-related pathways. However, prognostic significance of m6A regulators remains unclear in glioma. By integrating TCGA lower-grade glioma (LGG) and glioblastoma multiforme (GBM) gene expression data, we demonstrated both m6A-target genes were associated with prognosis activated Then, paired their target as m6A-related pairs (MGPs) using iPAGE algorithm, among...
An accurate potential energy model is crucial for biomolecular simulations. Despite many recent improvements of classical protein force fields, there are remaining key issues: much weaker temperature dependence folding/unfolding equilibrium and overly collapsed unfolded or disordered states. For the latter problem, a new water (TIP4P-D) has been proposed to correct significantly underestimated dispersion interactions. Here, using TIP4P-D, we reveal problems in current fields through failures...
To improve the accuracy of rainfall estimation by microwave links, this article presents a method for classifying wet and dry periods based on support vector machine (SVM). The average, minimum, maximum attenuation measurements in 5 min are applied as feature SVM after analysis relation between statistical parameters from seven links wet/dry periods. When baseline is needed retrieving path-averaged rain rate, can classify estimate dynamic with an optimal combination prior training....
Bisulfite sequencing is considered as the gold standard approach for measuring DNA methylation, which acts a pivotal part in regulating variety of biological processes without changes sequences. In this study, we introduced most prevalent methods processing bisulfite data and evaluated consistency acquired from different measurements liver cancer. Firstly, three commonly used assays, i.e., reduced-representation (RRBS), whole-genome (WGBS), targeted (targeted BS). Next, discussed principles...
Background: Telomerase reverse transcriptase promoter (TERT-p) mutation has been frequently found, but associated with contrary prognosis, in both low-grade gliomas and glioblastomas. For the (Grades II-III), TERT-p mutant patients have a better prognosis than wildtype patients, whereas for GBMs (Grade IV), is related to poor prognosis. We hypothesize that there exist high-risk LGGs who share GBM-like molecular features, including mutation, need more intensive treatment other LGGs. A...
Host-response-based diagnostics can improve the accuracy of diagnosing bacterial and viral infections, thereby reducing inappropriate antibiotic prescriptions. However, existing cohorts with limited sample size coarse infections types are unable to support exploration an accurate generalizable diagnostic model. Here, we curate largest infection host-response transcriptome data, including 11,247 samples across 89 blood datasets from 13 countries 21 platforms. We build a model for pathogen...
ABSTRACT Estimating the accuracy of a structure model is very crucial to promote usefulness protein prediction methods. Currently, vast majority successful quality assessment (or estimation, MAE) methods are knowledge-based. Based on molecular dynamics (MD) simulation with recently developed residue-specific force field (RSFF2), we develop method for absolute MAE at per-residue level. Using training set 31 models and test 24 from different proteins, performance our MD-based can reach or even...