A5100356816- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Genomics and Phylogenetic Studies
- Monoclonal and Polyclonal Antibodies Research
- Photosynthetic Processes and Mechanisms
- Estrogen and related hormone effects
- Cancer Research and Treatments
- CAR-T cell therapy research
- vaccines and immunoinformatics approaches
- Retinoids in leukemia and cellular processes
- Genetics, Bioinformatics, and Biomedical Research
- Tea Polyphenols and Effects
- Ginseng Biological Effects and Applications
- Plant Gene Expression Analysis
- Plant nutrient uptake and metabolism
- Amino Acid Enzymes and Metabolism
- HER2/EGFR in Cancer Research
- SARS-CoV-2 and COVID-19 Research
- Advanced NMR Techniques and Applications
- CRISPR and Genetic Engineering
- Bone Metabolism and Diseases
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Machine Learning and Data Classification
Shenyang Agricultural University
2021-2025
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
J. Craig Venter Institute
2020-2023
Baylor College of Medicine
2002-2022
The University of Texas Southwestern Medical Center
2020-2022
Guang’anmen Hospital
2022
Sun Yat-sen University
2022
Stony Brook University
2022
Harvard University Press
2022
Abstract The National Institute of Allergy and Infectious Diseases (NIAID) established the Bioinformatics Resource Center (BRC) program to assist researchers with analyzing growing body genome sequence other omics-related data. In this report, we describe merger PAThosystems Integration (PATRIC), Influenza Research Database (IRD) Virus Pathogen Analysis (ViPR) BRCs form Bacterial Viral (BV-BRC) https://www.bv-brc.org/. combined BV-BRC leverages functionality bacterial viral resources provide...
Tea is the world's oldest and most popular caffeine-containing beverage with immense economic, medicinal, cultural importance. Here, we present first high-quality nucleotide sequence of repeat-rich (80.9%), 3.02-Gb genome cultivated tea tree Camellia sinensis. We show that an extraordinarily large size resulted from slow, steady, long-term amplification a few LTR retrotransposon families. In addition to recent whole-genome duplication event, lineage-specific expansions genes associated...
Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for successful and rapid development emerging targeted anticancer therapeutics. Here, we describe identification patient NVP-BGJ398, a novel selective fibroblast growth factor receptor (FGFR) inhibitor. By intersecting genome-wide gene expression genomic alteration data with cell line-sensitivity across an annotated collection lines called Cancer Cell Line Encyclopedia,...
Sequencing technologies using nucleotide conversion techniques such as cytosine to thymine in bisulfite-seq and SLAM seq are powerful tools explore the chemical intricacies of cellular processes. To date, no one has developed a unified methodology for aligning converted sequences consolidating alignment these package. In this paper, we describe hierarchical indexing spliced transcripts-3 nucleotides (HISAT-3N), which can rapidly accurately align consisting any by leveraging index repeat...
Genomics-based neoantigen discovery can be enhanced by proteomic evidence, but there remains a lack of consensus on the performance different quality control methods for variant peptide identification in proteogenomics. We propose to use difference between accurately predicted and observed retention times each as metric evaluate methods. To this end, we develop AutoRT, deep learning algorithm with high accuracy time prediction. Analysis three cancer data sets total 287 tumor samples using...
Osteolysis induced by chronic Gram-negative bacterial infection underlies many bone diseases such as osteomyelitis, septic arthritis, and periodontitis. Drugs that inhibit lipopolysaccharide (LPS)-induced osteolysis are critically needed for the prevention of destruction in infective diseases. In this study, we assessed effect puerarin, a natural isoflavone isolated from Pueraria lobata OHWI root, on LPS-induced osteoclastogenesis loss. Our vitro study showed puerarin significantly inhibited...
Tislelizumab is an anti-programmed cell death protein 1 (anti-PD-1) monoclonal antibody specifically designed to minimize binding Fcγ receptors (FcγR).Here, we present the extended 3-year follow-up of a phase II study tislelizumab in 70 patients with relapsed/refractory classical Hodgkin lymphoma (cHL) who failed or were ineligible for autologous stem transplantation.With median 33.8 months, overall response rate by independent review committee was 87.1%, and complete (CR) 67.1%. Responses...
SUMMARY Flowering is an important developmental transition from the vegetative to reproductive phase in plants. The role of histone modifications regulation flowering time well documented; however, their Chinese cabbage remains unclear. In present study, we investigated a late‐bolting mutant, M1407 , which displayed phenotype after vernalization. MutMap, kompetitive allele‐specific PCR (KASP), and RNA interference (RNAi) analyses demonstrated that BrSWN encodes catalytic subunit Polycomb...
Lapatinib, a selective orally available inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 tyrosine kinases, is promising agent for the treatment breast cancer. We examined effect lapatinib on development mammary tumors in MMTV-erbB2 transgenic mice, which express wild-type under control mouse tumor virus promoter spontaneously develop estrogen (ER)-negative ErbB2-positive by 14 months age. Mice were treated from age 3 to 15 with vehicle (n = 17) or (30 75 mg/kg body weight; n 16...
To test whether a novel rexinoid, LG100268, prevents the development of preinvasive and invasive estrogen receptor-negative mammary tumorigenesis in MMTV-erbB2 mice.For breast cancer prevention, mice were treated with daily gastric gavage vehicle, LG100268 (10 mg/kg), or (100 mg/kg) for long term starting at 3 months age. For lesion study, vehicle 4 months.Long-term treatment significantly prevented tumor development. Median time (age) to was delayed from 217 days group 357 low-dose group....
To investigate the effect of dimethyl-sulfoxide wet-bonding technique on composite-dentin bonds and to explore its potential mechanism.
Effective countermeasures against the recent emergence and rapid expansion of 2019-Novel Coronavirus (2019-nCoV) require development data tools to understand monitor viral spread immune responses. However, little information about targets responses 2019-nCoV is available. We used Immune Epitope Database Analysis Resource (IEDB) resource catalog available related other coronaviruses, including SARS-CoV, which has high sequence similarity 2019-nCoV, best-characterized coronavirus in terms...
Abstract Chlorophyll (Chl) is an essential component of the photosynthetic apparatus and pigments in plant greening. Leaf color important agronomic commercial trait Chinese cabbage. In this study, we identified a pale green mutant pgm created by ethyl methane sulfonate (EMS) mutagenesis Compared with wild-type (FT), had lower Chl content higher / b ratio, imperfect chloroplast structure, non-photochemical quenching. However, its net rate biomass showed no significant differences. Genetic...
Abstract The oncogene erbB2 is overexpressed in 20% to 30% human breast cancers and most commonly estrogen receptor (ER)–negative cancers. Transgenic mice expressing develop ER-negative mammary tumors, mimicking carcinogenesis. Previously, we have shown that activator protein 1 (AP-1) regulates proliferation of cancer cells. We hypothesized blockade AP-1 mouse epithelial cells will suppress tumorigenesis induced by erbB2. Trigenic were generated crossing a bigenic pUHD-Tam67/MMTV-rtTA...
Abstract In pursuit of effective therapeutic agents for the estrogen receptor (ER)-negative breast cancer, we previously showed that bexarotene reduced mammary tumor development by 75% in ErbB2 mice. To further improve effectiveness cancer prevention, have now investigated effects a combinatorial therapy consisting two preventive drugs. On basis hypothesis, rexinoid LG100268 plus tamoxifen would more effectively prevent both ER-positive and ER-negative cancer. We treated p53-null gland mice...
Leaves are the main organ for photosynthesis, and variations in leaf color affect photosynthesis plant biomass formation. We created two similar whole-plant pale green mutants ( pem1 pem2 ) from double haploid (DH) Chinese cabbage line “FT” through ethyl methanesulfonate (EMS) mutagenesis of seeds. Photosynthetic pigment contents net photosynthetic rates were significantly lower than wild-type “FT,” chloroplast thylakoid endomembrane system was poor. Genetic analysis showed that mutated...
Background: Panax notoginseng saponins (PNS) may have an inhibitory effect against coronary artery disease (CAD); however, the mechanism is unclear. Recent research has begun to evaluate role of epigenetics in CAD. Our team found that hypomethylation miR-194 could be important Purpose: The aim this study was investigate PNS CAD and whether related methylation mi-R194. Methods: We conducted a randomized controlled trial with double-blind placebo design on 84 patients Treatment continued for 4...
Abstract Background The rexinoid bexarotene (LGD1069, Targretin) is a highly selective retinoid × receptor (RXR) agonist that inhibits the growth of pre-malignant and malignant breast cells. Bexarotene was shown to suppress development cancer in transgenic mice models without side effects. chemopreventive effects are due transcriptional modulation cell proliferation, differentiation apoptosis. Our goal present study obtain profile genes modulated by on mammary gland from three mouse an...
Here, we characterized a flap endonuclease 1 (FEN1) plus hairpin DNA probe (hpDNA) system, designated the HpSGN for both and RNA editing without sequence limitation. The compact size of system make it an ideal candidate in vivo delivery applications. In vitro biochemical studies showed that required less nuclease to cleave ssDNA substrates than SGN reported previously by factor ∼40. Also, proved can efficiently different targets vitro. cleaved genomic at efficiency ∼40% ∼20% bacterial human...