A5102910032- Cardiac, Anesthesia and Surgical Outcomes
- Genomics and Phylogenetic Studies
- Aortic aneurysm repair treatments
- Fractal and DNA sequence analysis
- Renal and Vascular Pathologies
- RNA and protein synthesis mechanisms
- VLSI and Analog Circuit Testing
- Pancreatic and Hepatic Oncology Research
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced NMR Techniques and Applications
- Cardiac Arrest and Resuscitation
- Machine Learning in Bioinformatics
- Amino Acid Enzymes and Metabolism
- Physical Unclonable Functions (PUFs) and Hardware Security
- Enzyme Structure and Function
- Machine Learning and Data Classification
- RNA modifications and cancer
- Vascular Procedures and Complications
- SARS-CoV-2 and COVID-19 Research
- Transplantation: Methods and Outcomes
- Gene expression and cancer classification
- Archaeology and Natural History
- VLSI and FPGA Design Techniques
- Environmental DNA in Biodiversity Studies
- Nasal Surgery and Airway Studies
Massachusetts General Hospital
2024-2025
The University of Texas Southwestern Medical Center
2020-2024
Southwestern Medical Center
2022-2024
Harvard University
2024
Ambulance Victoria
2023
Park Terrace Care Center
2023
RELX Group (United States)
2023
Southern Methodist University
1996-2022
Centre de Recherche en Informatique
2019
ParisTech
2019
Sequencing technologies using nucleotide conversion techniques such as cytosine to thymine in bisulfite-seq and SLAM seq are powerful tools explore the chemical intricacies of cellular processes. To date, no one has developed a unified methodology for aligning converted sequences consolidating alignment these package. In this paper, we describe hierarchical indexing spliced transcripts-3 nucleotides (HISAT-3N), which can rapidly accurately align consisting any by leveraging index repeat...
Each severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant renews concerns about decreased vaccine neutralization weakening efficacy. However, while prevention of infection varies, protection from disease remains and implicates immunity beyond in Polyclonal antibodies function through Fab domains that neutralize virus Fc induce non-neutralizing responses via engagement receptors on immune cells. To understand how vaccines promote protection, we leverage sera 51 SARS-CoV-2...
IEEE P1687 is a valuable tool for accessing on-chip instruments during test, diagnosis, debug, and board configuration. However, most of these should not be available to an end user in the field. We propose method hiding network that utilizes "locking" segment insertion bit (LSIB) can only opened when pre-defined values, corresponding key, are present particular bits chain. also introduce "trap" bits, which further reduce effectiveness brute force attacks by permanently locking LSIB...
Abstract Introduction Survival from refractory out of hospital cardiac arrest (OHCA) without timely return spontaneous circulation (ROSC) utilising conventional advanced life support (ACLS) therapies is dismal. CHEER3 was a safety and feasibility study pre-hospital deployed extracorporeal membrane oxygenation (ECMO) during cardiopulmonary resuscitation (ECPR) for OHCA in metropolitan Australia. Methods This single jurisdiction, single-arm study. Physicians, with pre-existing ECMO expertise,...
Background Compared to the great saphenous vein, there is a relative paucity of data in literature focused on treating small vein (SSV). Our goal was evaluate and analyze national registry related diagnosis treatment SSV identify practice patterns clinical outcomes. Method Subjects undergoing interventions between April 2014 March 2023 were identified AVLS PRO Venous Registry. Data points included Clinical, Etiological, Anatomical, Pathological (CEAP) classifications; Clinical Severity Score...
Curative intent for localized pancreatic cancer (pancreatic ductal adenocarcinoma [PDAC]) requires surgery, but despite improved perioperative outcomes, surgery remains underutilized. This study analyzed the Texas Cancer Registry (TCR) to identify resectable PDAC patients who underwent curative-intent in between 2004 and 2018. We then evaluated demographic clinical factors associated with failure operate survival (OS).
Neuraminidase treatment of orosomucoid from human plasma results in an increase the antigenicity glycoprotein rabbits. Native and desialized react a qualitatively quantitatively similar manner with antibodies to normal or antigen. Thus sialic acid, though terminal sugar, is not important determinant antigenic group.
Treatment decisions for the elderly with abdominal aortic aneurysms (AAAs) are challenging. With advancing age, risk of endovascular aneurysm repair (EVAR) increases while life expectancy decreases, which may nullify benefit EVAR. The purpose this study was to quantify impact EVAR on 1-year mortality in patients advanced age.The 2003-2020 Vascular Quality Initiative Database utilized identify who underwent AAAs. Patients were included if they 80 years age or older. Exclusions non-elective...
Cell-aware faults have previously been proposed to more effectively detect defects within gates. At the same time, n-detect test sets that provide multiple detections of each stuck-at fault are often used maximize detection unmodeled defects. However, not particularly effective at fortuitously detecting all untargeted cell-aware faults. In this paper, we investigate effectiveness different types ATPG for efficiently difficult cell-aware-type and explain why optimizing n- using while still...
Abstract Signal-induced transcriptional programs regulate critical biological processes through the precise spatiotemporal activation of Immediate Early Genes (IEGs); however, mechanisms transcription induction remain poorly understood. By combining an acute depletion system with several genomics approaches to interrogate synchronized, temporal transcription, we reveal that KAP1/TRIM28 is a first responder fulfills and heightened demand IEGs. Acute KAP1 loss triggers increase in RNA...
We describe a parameterized random value extraction function for producing symbol strings based upon user-specified radix value. The presentation of the extractor is accompanied with theoretical discussion that describes how value, and hence set cardinality, affects entropy an extracted string. Experimental results are provided where respect to different values analyzed randomness quality. empirical data obtained by applying our weakly source provides inter-packet delay spacings observed...
In this work, we investigate using Fourier coefficients (FCs) for capturing useful information about viral sequences in a computationally efficient and compact manner. Specifically, extract geographic submission location from SARS-CoV-2 sequence headers submitted to the GISAID Initiative, calculate corresponding FCs, use FCs classify these according location. We show that serve as numerical summaries allow manipulation, identification, differentiation via classical mathematical statistical...
Each novel SARS-CoV-2 variant renews concerns about decreased vaccine efficacy caused by evasion of induced neutralizing antibodies. However, accumulating epidemiological data show that while prevention infection varies, protection from severe disease and death remains high. Thus, immune responses beyond neutralization could contribute to efficacy. Polyclonal antibodies function through their Fab domains neutralize virus directly, Fc induce non-neutralizing host via engagement receptors on...
The objective was to investigate the effectiveness of co-phenylcaine as a topical anesthetic agent for nasal mucosal biopsy.A prospective study.Nasal biopsy specimens were taken from site just anterior inferior turbinate following anesthesia with co-phenylcaine. All volunteers graded pain according standard visual analogue scale (0-10) (VAS) scoring, and all followed up after 24 hours any epistaxis.Ninety removed 41 patients in all. Eight-two percent did not report discomfort this procedure...
Abstract Nucleotide conversion sequencing technologies such as bisulfite-seq and SLAM-seq are powerful tools to explore the intricacies of cellular processes. In this paper, we describe HISAT-3N (hierarchical indexing for spliced alignment transcripts - 3 nucleotides), which rapidly accurately aligns sequences consisting nucleotide conversions by leveraging hierarchical index repeat algorithms originally developed HISAT software. Tests on real simulated data sets demonstrate that is over 7...
The comparison of genomic sequences is a important undertaking, for example in phylogenetic and differential sequence analyses. In this work we describe three filter designs that can be applied to power spectra (PS) any lengths reduce their size while maintaining the relative distances which they provide are relevant data reduction, sorting, correlation studies an ensemble sequences. Specifically present: Minimal Variance Filtering (MVF), where subsets coefficients with highest variance...