A5100321040- Diverse Approaches in Healthcare and Education Studies
- Cell Adhesion Molecules Research
- Retirement, Disability, and Employment
- Psychosocial Factors Impacting Youth
- Insurance and Financial Risk Management
- Obesity, Physical Activity, Diet
- Healthcare Policy and Management
- Financial Literacy, Pension, Retirement Analysis
- Cellular Mechanics and Interactions
- Global Health Care Issues
- Sleep and Work-Related Fatigue
- Housing Market and Economics
- Diverse Topics in Contemporary Research
- Health and Wellbeing Research
- Consumer Perception and Purchasing Behavior
- Education and Learning Interventions
- Dermatology and Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Semiconductor materials and devices
- Health disparities and outcomes
- Advancements in Semiconductor Devices and Circuit Design
- Traffic and Road Safety
- Thin-Film Transistor Technologies
- Insurance, Mortality, Demography, Risk Management
- Energy and Environmental Systems
Kyung Hee University
2024
Kookmin University
2009-2024
Dong-A University
2014-2024
Korea Institute of Machinery and Materials
2022-2024
University of California, Berkeley
2023
University of California, San Diego
2018-2023
QB3
2023
The University of Texas Southwestern Medical Center
2018-2022
Southwestern Medical Center
2022
Cheju Halla General Hospital
2022
Each severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant renews concerns about decreased vaccine neutralization weakening efficacy. However, while prevention of infection varies, protection from disease remains and implicates immunity beyond in Polyclonal antibodies function through Fab domains that neutralize virus Fc induce non-neutralizing responses via engagement receptors on immune cells. To understand how vaccines promote protection, we leverage sera 51 SARS-CoV-2...
Objectives: To estimate the effects of wages on obesity and body mass. Methods: Data household heads, aged 20 to 65 years, with full-time jobs, were drawn from Panel Study Income Dynamics for 2003 2007. The is a nationally representative sample. Instrumental variables (IV) created using knowledge computer software state legal minimum wages. Least squares (linear regression) corrected standard errors used equations. Results: Statistical tests revealed both instruments strong over-identifying...
Upregulation of Cyclin E1 and subsequent activation CDK2 accelerates cell cycle progression from G1 to S phase is a common oncogenic driver in gynecological malignancies. WEE1 kinase counteracts the effects E1/CDK2 by regulating multiple checkpoints. Here we characterized relationship between sensitivity selective inhibitor azenosertib. We found that ovarian cancer lines with high levels endogenous expression or forced overexpression were exquisitely sensitive azenosertib these results...
Increasing matrix stiffness caused by the extracellular (ECM) deposition surrounding cancer cells is accompanied epithelial-mesenchymal transition (EMT). Here, we show that expression levels of EMT marker genes along with discoidin domain receptor 2 (DDR2) can increase upon stiffening. DDR2 silencing short hairpin RNA downregulated markers. Promoter analysis and chromatin immunoprecipitation revealed c-Myb LEF1 may be responsible for induction during cell culture on a stiff matrix....
Epidermal growth factor (EGF) plays a critical role in fibroblasts by stimulating the production of collagen and supports cell renewal through interaction between keratinocytes fibroblasts. It is well known that contractile activity required for remodeling extracellular matrix (ECM), which contributes to skin elasticity. However, EGF contraction aged under 3-dimensional (3D) culture conditions not yet fully understood. In present study, we demonstrated young spread proliferated more rapidly...
Uveal melanoma (UM) is the most prevalent cancer of eye in adults, driven by activating mutation GNAQ/GNA11; however, there are limited therapies against UM and metastatic (mUM). Here, we perform a high-throughput chemogenetic drug screen GNAQ-mutant contrasted with BRAF-mutant cutaneous melanoma, defining druggable landscape these distinct subtypes. Across all compounds, darovasertib demonstrates highest preferential activity UM. Our investigation reveals that potently inhibits PKC as well...
Whereas some studies show statistically significant linear associations between consumption at full-service restaurants and consumer incomes, of fast-food fail to find associations. In this study, nationally representative data were drawn from the 1994–1996 Continuing Survey Food Intakes by Individuals accompanying Diet Health Knowledge Survey. The sample contained 4972 individuals who 21 years age or older. Dependent variables measured number restaurant visits on 2 nonconsecutive days....
Discoidin domain receptors (DDRs) are unusual receptor tyrosine kinases (RTKs) that activated by fibrillar collagens instead of soluble growth factors. DDRs play an important role in various cellular functions and disease processes, including malignant progression. Compared to other RTKs, have relatively long juxtamembrane domains, which believed contribute function. Despite this possibility, the function mechanism not yet been fully elucidated. In study, we found cytoplasmic 2 (JM2) region...
Perioperative blood management is an important issue in the treatment of elderly patients at increased risk postoperative complications. Accordingly, tranexamic acid (TXA) widely administered to reduce loss and transfusion requirements. In this case-control study, effect topical TXA on outcomes with femoral neck fractures after hemiarthroplasty was evaluated.This study enrolled (age ≥ 70 years) who underwent cementless bipolar for between January 2015 2017. The group comprised 72 received...
Aims: Traffic safety is a significant public health challenge, and vehicle crashes account for the majority of injuries. This study aims to identify whether drivers' characteristics past traffic violations may predict in Korea.
Mammalian diaphanous-related formin 1 (mDia1) expression has been linked with progression of malignant cancers in various tissues. However, the precise molecular mechanism underlying mDia1-mediated invasion cancer cells not fully elucidated. In this study, we found that mDia1 is upregulated invasive breast cells. Knockdown profoundly reduced activity by controlling cellular localization membrane type 1-matrix metalloproteinase (MT1-MMP) through interaction microtubule tracks. Gene silencing...
The collagen matrix constitutes the primary extracellular (ECM) portion of mammalian connective tissues in which interaction cell and surrounding fibers has a significant impact on tissue physiology, including morphogenesis, development motility. Discoidin domain receptors (DDR1 DDR2) have been identified as receptor tyrosine kinases that are activated upon binding. However, there is lack evidence regarding effect DDRs mechanical between fibroblasts ECM. In this study, we demonstrated one...
Stasis dermatitis is an itchy, scaly, and hyperpigmented condition of the lower leg due to venous insufficiency. Hemosiderin and/or melanin have been considered responsible for brown pigmentation. However, there are not sufficient histopathologic studies. In this retrospective study hospital records biopsy slides 20 patients were reviewed determine pathogenetic mechanisms pigmentation in stasis dermatitis. Fifteen men (75%) 5 women (25%) with a mean age 46.2+/-8.2 yr (18-76), at onset...
In this paper, we propose a new pattern model, called the structural binary (SBP) for object tracking. For proposed SBP introduce an alternate thresholding scheme to generate set of multiple SBPs. The encodes not only consisting binarized differences between average intensities subregions within target region, but also spatial configuration subregions. With define metric similarity models from and candidate localization, which is based on isotropic kernel weighted Hamming distance. To...