A5091197585- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Musculoskeletal pain and rehabilitation
- Shoulder Injury and Treatment
- Balance, Gait, and Falls Prevention
- Spinal Cord Injury Research
- Muscle activation and electromyography studies
- Botulinum Toxin and Related Neurological Disorders
- Fuel Cells and Related Materials
- Genomics and Phylogenetic Studies
- Sports injuries and prevention
- Electrocatalysts for Energy Conversion
- Semiconductor materials and devices
- Extracellular vesicles in disease
- Thin-Film Transistor Technologies
- RNA and protein synthesis mechanisms
- ZnO doping and properties
- Spine and Intervertebral Disc Pathology
- Cancer Genomics and Diagnostics
- Long-Term Effects of COVID-19
- Machine Learning and Data Classification
- Family and Disability Support Research
- Infant Development and Preterm Care
- Acute Ischemic Stroke Management
- Stock Market Forecasting Methods
Jeonju University
2024-2025
University of Maryland, Baltimore
2024-2025
Asan Medical Center
2025
Yonsei University
2019-2024
Korea University
2016-2023
Korea Institute of Science and Technology
2023
Konkuk University
2022
Samsung (South Korea)
2006-2022
The University of Texas Southwestern Medical Center
2019-2022
Southwestern Medical Center
2021-2022
Sequencing technologies using nucleotide conversion techniques such as cytosine to thymine in bisulfite-seq and SLAM seq are powerful tools explore the chemical intricacies of cellular processes. To date, no one has developed a unified methodology for aligning converted sequences consolidating alignment these package. In this paper, we describe hierarchical indexing spliced transcripts-3 nucleotides (HISAT-3N), which can rapidly accurately align consisting any by leveraging index repeat...
Abstract Viral infection is one of the leading causes brain encephalitis and meningitis. Recently, it was reported that Toll‐like receptor‐3 (TLR3) induces a double‐stranded RNA (dsRNA)‐mediated inflammatory signal in cells innate immune system, studies suggested dsRNA may induce inflammation central nervous system (CNS) by activating CNS‐resident glial cells. To explore further connection between CNS, we have studied effects stimulation astrocytes. Our results show injection...
Abstract Cell-free DNA (cfDNA) has been implicated as an important biomarker in cancer management. Thus, efficient techniques for cfDNA extraction are necessary precision medicine. We developed a centrifugation-free microfluidic chip capable of extracting from plasma samples through circuits within 15 min under vacuum pressure using immiscible solvent. The had excellent performance that was comparable to the most widely used commercial product (QIAamp kit) terms efficiency, purity, and...
Each severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant renews concerns about decreased vaccine neutralization weakening efficacy. However, while prevention of infection varies, protection from disease remains and implicates immunity beyond in Polyclonal antibodies function through Fab domains that neutralize virus Fc induce non-neutralizing responses via engagement receptors on immune cells. To understand how vaccines promote protection, we leverage sera 51 SARS-CoV-2...
Metaverse physical therapy (MPT), an adjuvant technology for the rehabilitation of children with cerebral palsy (CP), has gained notoriety in clinical field owing to its accessibility and because it provides motivation rehabilitation. The aim is compare gross motor function cardiopulmonary function, activities daily living, quality life (QOL), perceived risk coronavirus disease (COVID)-19 transmission between MPT conventional (CPT). A convenience sample 26 CP (mean age, 11.23 ± 3.24 years,...
Background Arm-leg coordinated humanoid exoskeletal robots offer a solution to the ‘unnatural’ gait patterns seen in current leg-only exoskeletons, but their neuromechanical control mechanisms require further exploration. Objective This study investigates properties and modulation of cervical lumbar central pattern generators (CPGs) across different training conditions. Methods Eleven healthy adults (mean age: 25.27 ± 1.95 years; 5 females, 6 males) participated analysis involving...
Plasma extracellular vesicles (EVs) are cell-derived lipid particles and reportedly play a role in sepsis pathogenesis. This study aimed to identify EV cargo proteins septic patients explore their association with key pathophysiology. EVs were subjected Tandem Mass Tag (TMT)-based quantitative proteomic analysis. We identified 522 differentially expressed (DE) (n=15) compared the healthy controls (n=10). The KEGG analysis of DE revealed multiple functional pathways linked sepsis, e.g.,...
Trauma remains a leading cause of morbidity and mortality in part due to secondary multi-organ injury. However, our ability predict the downstream pathophysiology adverse outcomes trauma is limited. Here, we select panel microRNAs (miRNAs) biomarker candidates based on plasma RNA-Seq analysis patients unique pro-inflammatory nucleotide motif structures identified via machine learning-guided computer exhaustive search algorithm. We test miRNAs for their association with various...
Although early maladaptive schemas (EMSs) have been linked to suicidal ideation, their heterogeneous nature has not fully explored in this relationship. This study sought identify distinct latent profiles based on 18 EMSs a clinical sample and examine how these differ relation ideation suicide risk factors, such as perceived burdensomeness, thwarted belongingness fearlessness about death. Data from routine assessments of 799 outpatients with mood disorders (aged 18-49 years, 513 female, 286...
BACKGROUND: While Walkbot-assisted locomotor training (WLT) provided ample evidence on balance and gait improvements, the therapeutic effects cardiopulmonary psychological elements as well fall confidence are unknown in stroke survivors. OB
Extraction of cell-free DNA (cfDNA), which exists at an extremely low concentration in plasma, is a critical process for either targeted-sensing or massive sequencing DNAs. However, such small amount cannot be fully obtained without high-speed centrifugation (<20,000 g). Here, we developed centrifugation-free cfDNA extraction method and system that utilizes immiscible solvent under single vacuum pressure throughout the entire process. It has been named Pressure Immiscibility-Based EXtraction...
Abstract Abnormal spasticity and associated synergistic patterns are the most common neuromuscular impairments affecting ankle–knee–hip interlimb coordinated gait kinematics kinetics in patients with hemiparetic stroke. Although stroke undergo various treatments to improve movement, it remains unknown how change after robot-assisted conventional treatment. We developed an innovative humanoid robot (ICT) mitigate abnormal patterns. The objective of preliminary clinical trial was compare...
Ever since the introduction of high bandwidth memory (HBM DRAM) and its succeeding line-ups, HBM DRAM has been heralded as a prominent solution to tackle wall problem. However, despite continual advancements advent high-end systems, including supercomputers, hyper-scale data centers machine learning accelerators, are expediting requirements for higher-performance solutions. To accommodate increasing system-level demands, we introduce HBM3 DRAM, which employs multiple new features design...
The rate of obesity in adolescents has increased due to social distancing measures and school closures caused by the COVID-19 pandemic. These issues have change their lifestyles eating habits. Furthermore, growth inactive behavior computer screen or watching TV time, as well reduction physical activity, could similarly be related with obesity. To overcome this problem, we recently developed an artificial intelligence (AI)-based gesture recognition game application called Super Kids Adventure...
The present study aimed to compare the effects of a deep learning-based digital application with physical therapy (DPT) and those conventional (CPT) on back pain intensity, limited functional ability, lower extremity weakness, radicular symptoms, range motion (ROM), movement, quality life, cost-effectiveness, postintervention questionnaires for perceived transmission risk COVID-19 satisfaction results in 100 participants low (LBP).One hundred LBP were randomized into either DPT or CPT...
Neuroinflammation reportedly plays a critical role in the pathogenesis of sepsis-associated encephalopathy (SAE). We previously reported that circulating plasma extracellular vesicles (EVs) from septic mice are proinflammatory. In current study, we tested sepsis EVs neuroinflammation.
Inflammation in the peripheral nervous system (PNS) is one of characteristics virus-induced neuropathy. In this inflammatory response, Schwann cells are actively involved. Previously, toll-like receptor 3 (TLR3) was reported as a for double-stranded RNA (dsRNA) that induces antiviral and responses innate immune system. study, we investigated expression putative role TLR3 cells. constitutively expressed Stimulation with polyinosinic-polycytidylic acid, synthetic dsRNA analogue, induced...
Robot-assisted gait training (RAGT) was initially developed based on the passive controlled (PC) mode, where target or ideal locomotor kinematic trajectory is predefined and a patient basically 'rides' robot instead of actively participating in actual relearning process. A new insightful contemporary neuroscience mechatronic evidence suggest that robotic-based can be best achieved through active interactive (AI) mode rather than PC mode.The purpose this study to compare pattern gait-related...