A5083437740- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Anorectal Disease Treatments and Outcomes
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Diverticular Disease and Complications
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- RNA modifications and cancer
- Stoma care and complications
- Gastrointestinal Tumor Research and Treatment
- Enhanced Recovery After Surgery
Shanghai East Hospital
2016-2023
Beijing Aerospace General Hospital
2023
Creative Commons
2023
Inform (Germany)
2022
Development Fund
2022
Second Military Medical University
2009-2018
Changhai Hospital
2009-2018
Zhejiang Provincial People's Hospital
2013
In recent years, natural orifice specimen extraction surgery (NOSES) in the treatment of colorectal cancer has attracted widespread attention. The potential benefits NOSES including reduction postoperative pain and wound complications, less use analgesic, faster recovery bowel function, shorter length hospital stay, better cosmetic psychological effect have been described surgery. Despite significant decrease surgical trauma observed, pitfalls this technique demonstrated. Particularly,...
Resistance to radiotherapy remains a major unmet clinical obstacle in the treatment of locally advanced rectal cancer. Cancer stem cells (CSCs) are considered mediate tumor development and radioresistance. However, role CSCs regulating resistance colorectal cancer (CRC) largely unknown. We established two radioresistant CRC cell lines, HCT116-R RKO-R, using fractionated irradiation. Analysis miRNA sequencing quantitative real-time PCR confirmed lower levels miR-7-5p both compared their...
Gene expression profiling provides an opportunity to develop robust prognostic markers of colorectal carcinoma (CRC). However, the have not been applied for clinical decision making. We aimed immunohistochemistry signature using microarray data predicting CRC prognosis.We evaluated 25 gene signatures in independent datasets with prognosis information and constructed a subnetwork high concordance repeatable values. Tumours were examined immunohistochemically network-centric top overlapping...
MicroRNAs (miRNAs) are small noncoding RNAs that potentially play a critical role in tumorigenesis. Mounting evidence indicates one specific miRNA: miR-320b is down regulated numerous human cancers, including colorectal cancer (CRC); making the hypothesis may key tumorigenesis plausible. However, its carcinogenesis remains poorly defined. The goal of this study to better clarify tumor growth CRC. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was conducted detect...
Ribosome-binding protein 1 (RRBP1) has been implicated in the regulation of unfolded response, which is involved almost every aspect cancer development. We aimed to explore significance RRBP1 progression and prognosis colorectal (CRC). The study population consisted 856 patients with stage I–III CRC from two hospitals. expression was examined by immunohistochemisty (IHC) tissues. correlation occurrence assessed paired cancer-adjacent Factors contributing were evaluated a training-validation...
Forkhead box protein M1 (FOXM1) is an oncogene regulating tumor growth and metastasis. Exosome was suggested to mediate cell communication by delivering active molecules in cancers. However, the existence of FOXM1 circulating exosomes role exosome gastric cancer (GC) were not clear. This study aims investigate potential related long noncoding RNA (FRLnc1) GC.The prepared CD63 immunomagnetic beads (CD63-IMB) had characteristics good dispersity high magnetic response. The isolated presented...
BACKGROUND: Recent studies showed that p53 and p21 may play major roles in determining tumor radiosensitivity through the apoptosis pathway. The aim of this study was to investigate predicting value human rectal carcinoma. METHODS: p21/WAF1 expressions formalin fixed, paraffin-embedded, preradiation biopsy samples from 49 patients with primary carcinoma were analyzed immunohistochemically. their relationships histopathologic changes after radiation other clinical features evaluated. RESULTS:...
Periostin (POSTN) expression in cancer cells and circulation has been related to poor prognosis of colorectal carcinoma (CRC). However, the role POSTN expressed intra-tumoral stroma on CRC progression remains largely unknown. This study enrolled 1098 patients who received surgical treatment Shanghai Guangzhou, Mainland China. In cohort, immunohistochemistry score stromal increased consecutively from adjacent mucosa, primary tissues, metastatic tissues (P < 0.001), while medium- high-stromal...
Resistance to radiotherapy is the main reason causing treatment failure in locally advanced rectal cancer. MicroRNAs (miRNAs) have been well demonstrated regulate cancer development and progression. However, how miRNAs resistance colorectal remains unknown. Herein, we established two human cell lines resistant radiotherapy, named HCT116-R RKO-R, using strategy of fractionated irradiation. The radioresistant phenotypical changes were validated by viability assay, colony formation assay...
Goals To gain an insight into the putative role of annexin A5 (ANXA5) in tumor stage and its clinical outcome. Background ANXA5 is a calcium-binding protein, which has been implicated carcinogenesis several carcinomas. However, colorectal cancer (CRC) unclear. Study We investigated expression adenocarcinoma. This study included 207 consecutive patients with sporadic CRC. Paired tissue samples corresponding nonmalignant tissues were obtained by surgical resection. mRNA protein each assessed...
The cancer stem cell (CSC) model depicts that tumors are hierarchically organized and maintained by CSCs lying at the apex. have been "identified" in a variety of through tumor-forming assay, which tumor cells distinguished certain surface marker (known as CSC marker) were separately transplanted into immunodeficient mice. In such assays, positive but not negative for (hereby defined CSC+ CSC− cells, respectively) ability generating both progenies. However, here we show exhibit similar...
Anastomotic bleeding is rare but one of the dangerous complications, with associated morbidity and mortality, at early stage rectal cancer surgery. The aim this study was to report our experiences in treatment emergency condition. We retrospectively analyzed general characteristics, outcome patients severe anastomotic after undergoing resection stapled anastomosis Department Colorectal Surgery Changhai Hospital (China) between January 2011 December 2013. occurred six out 2,181 (0.3%) who...
Growing evidence has revealed that the E2F family of transcription factor 2 (E2F2) participates in tumorigenesis and progression various tumors, but its role colorectal cancer (CRC) remains largely unknown. Herein, aim our study was to investigate exact E2F2 CRC. The expression levels CRC were appraised based on Tumor Immune Estimate Resource (TIMER), Oncomine, Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) database. results further confirmed using tumor tissues normal controls by...