A5100731538- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Ferroptosis and cancer prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- Enhanced Recovery After Surgery
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Neurological Disorders and Treatments
- Hospital Admissions and Outcomes
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Acupuncture Treatment Research Studies
- Neuroblastoma Research and Treatments
- RNA Research and Splicing
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
Fujian Medical University
2006-2022
Union Hospital
2006-2022
Third Affiliated Hospital of Sun Yat-sen University
2016
Sun Yat-sen University
2016
Shanghai Children's Medical Center
2014
Total mesorectal excision with fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy is a standard treatment of locally advanced rectal cancer. This study investigated the addition oxaliplatin without radiotherapy.In this multicenter, open-label, phase III trial, we randomly assigned (1:1:1) Chinese adults (age 18 to 75 years) stage II/III cancer three treatments: five 2-week cycles infusional fluorouracil (leucovorin 400 mg/m(2), 2.4 g/m(2) over 48 h) plus...
SPINK4 is known as a gastrointestinal peptide in the tract and abundantly expressed human goblet cells. The clinical significance of colorectal cancer (CRC) largely unknown.We retrieved expression data 1168 CRC patients from 3 Gene Expression Omnibus (GEO) datasets (GSE24551, GSE39582, GSE32323) Cancer Genome Atlas (TCGA) to compare level between tissues normal evaluate its value predicting survival patients. At protein level, these results were further confirmed by mining Human Protein...
To provide systematic insight into the composition and expression of transfer RNA (tRNA) derivatives transcriptome in colorectal cancer (CRC). tRNA profiles three pairs CRC adjacent normal colon tissues were performed by tRNA-derived small fragments (tRFs) halves (tiRNA) sequencing, microarray data transcriptomes from paired controls retrieved Gene Expression Omnibus database. The differentially expressed tRFs tiRNAs genes between samples screened. functional regulations tRF tiRNA gene...
This study was designed to detect global gene expressions of primary advanced colorectal cancer (ACC) patients who have undergone FOLFOX4 chemotherapy and screen valuable biomarkers predict the effects chemotherapy. Samples from ACC were collected. Their evaluated divided into sensitive group (experimental group) non-sensitive (control group). Cancerous tissue expression profiles detected by chip technology. Two groups with differentially expressed genes screened cluster analysis...
<h3>Objective</h3> The aims of this study were to detect differences in PA28 <i>γ</i> expression between healthy colorectal, colorectal adenoma, and cancer (CRC) tissues explore the significance development CRC. <h3>Methods</h3> Western blotting was used assay protein CRC tissue. Tissue array tissues. Follow-up performed patients with CRC, survival analysis correlation time after surgical resections. <h3>Results</h3> results revealed that higher tissue than colorectum. showed low colorectum,...
High expression of small proline‑rich protein 1A (SPRR1A) has been shown to be associated with tumor prognosis; however, the association between SPRR1A and colon cancer prognosis remains unclear. The present study sought evaluate clinicopathological characteristics cancer, examine its potential prognostic value. A total 114 patients were included. was evaluated by immunohistochemical staining, parameters analyzed. value analyzed Cox regression analysis, Oncomine database R2 platform....
Objectives: To evaluate pretreatment tumor thickness in predicting pathologic complete response (pCR) of stage II/III rectal adenocarcinoma to neoadjuvant chemoradiation (chemoradiotherapy [CRT]). Methods: We retrospectively analyzed 185 patients who were diagnosed with II or III from January 2011 July 2013 and treated intensity-modulated radiation therapy (45 Gy 1.8-Gy fractions pelvis 50 2-Gy as an integrated boost) 3 dimensionally conformal followed by additional 5.4-Gy tumor)...
Aims. To evaluate the impact of body mass index (BMI) on surgical outcome laparoscopic total mesorectal excision (laTME) for locally advanced rectal cancer (LARC, clinically staged as UICC stage II/III) after neoadjuvant chemoradiotherapy (nCRT). Methods. 312 LARC patients undergoing laTME nCRT were divided into nonobese (BMI < 25.0 kg/m 2 ,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>249</mml:mn></mml:math>) and obese ≥...
Background: Lynch syndrome is a genetic disease resulting from mismatch repair gene mutation. Vaccine therapy can enhance the immunogenicity of and improve therapeutic efficacy immunotherapy. However, there no approved vaccine coming onto market. Methods: Herein, we used knockdown method to construct cell model, paving way for us develop tumor lysate vaccine. Then isograft technique was employed constructing tumor-bearing mouse model syndrome. And this treated with PD-1 monoclonal antibody...
Aims. To compare the surgical and oncological outcomes of rectal mucinous adenocarcinomas treated with neoadjuvant chemoradiotherapy versus surgery alone. Methods. A total 167 locally advanced adenocarcinoma patients alone between 2008 2014 were matched using propensity score; compared. Results. Ninety-six matched. Postoperative morbidity was similar groups. Sphincter preservation rate higher in receiving (79.2% 60.4%, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...