A5010094101- Hair Growth and Disorders
- Skin and Cellular Biology Research
- Wnt/β-catenin signaling in development and cancer
- Chromosomal and Genetic Variations
- Hedgehog Signaling Pathway Studies
- Skin Protection and Aging
- Cancer and Skin Lesions
- Hippo pathway signaling and YAP/TAZ
- Genomics and Phylogenetic Studies
- Cancer Cells and Metastasis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Colorectal Cancer Surgical Treatments
- Silk-based biomaterials and applications
- Effects of Radiation Exposure
- Pluripotent Stem Cells Research
- Fibroblast Growth Factor Research
- Genetic diversity and population structure
- melanin and skin pigmentation
- Wound Healing and Treatments
- Plant Reproductive Biology
- Colorectal and Anal Carcinomas
- Cellular Mechanics and Interactions
- Cancer-related Molecular Pathways
- Ocular Disorders and Treatments
- Connexins and lens biology
Shenzhen University
2020-2024
University of Southern California
2003-2023
National Tsing Hua University
2023
Southern California University for Professional Studies
2023
Foundation for Advancement of International Science
2023
Biodiversity Research Center, Academia Sinica
2023
Shenzhen University Health Science Center
2020-2023
Fuzhou University
2012-2018
University of Miami
2018
University of California, Los Angeles
2009-2010
Microchromosomes are prevalent in nonmammalian vertebrates [P. D. Waters et al. , Proc. Natl. Acad. Sci. U.S.A. 118 (2021)], but a few of them missing bird genome assemblies. Here, we present new chicken reference containing all autosomes, Z and W chromosome, with gaps closed except for the W. We identified ten small microchromosomes (termed dot chromosomes) distinct sequence epigenetic features, among which six were newly assembled. Those chromosomes exhibit extremely high GC content level...
The karyotype of most birds has remained considerably stable during more than 100 million years' evolution, except for some groups, such as parrots. evolutionary processes and underlying genetic mechanism chromosomal rearrangements in parrots, however, are poorly understood. Here, using chromosome-level assemblies four parrot genomes, we uncover frequent chromosome fusions fissions, with them occurring independently among lineages. increased activities parrots likely associated...
The slow-evolving invertebrate amphioxus has an irreplaceable role in advancing our understanding of the vertebrate origin and innovations. Here we resolve nearly complete chromosomal genomes three species, one which best recapitulates 17 chordate ancestor linkage groups. We reconstruct fusions, retention, or rearrangements between descendants whole-genome duplications, gave rise to extant microchromosomes likely existed ancestor. Similar vertebrates, genome gradually establishes its...
The feather is a complex epidermal organ with hierarchical branches and represents multi-layered topological transformation of keratinocyte sheets. Feathers are made in follicles. basics morphogenesis were previously described (Lucas Stettenheim, 1972). Here we review new molecular cellular data. After buds form (Jiang et al., this issue), they invaginate into the dermis to Above dermal papilla proliferating collar. Distal it ramogenic zone where cylinder starts differentiate barb ridges or...
Abstract Chemotherapy and radiotherapy are common modalities for cancer treatment. While targeting rapidly growing cells, they also damage normal tissues cause adverse effects. From the initial insult such as DNA double‐strand break, production of reactive oxygen species ( ROS ) a general stress response, there complex regulatory mechanisms that control actual tissue process. Besides apoptosis, range outcomes damaged cells possible including cell cycle arrest, senescence, mitotic...
Abstract The transition from natal downs for heat conservation to juvenile feathers simple flight is a remarkable environmental adaptation process in avian evolution. However, the underlying epigenetic mechanism this primary feather mostly unknown. Here we conducted time-ordered gene co-expression network construction, analysis, and functional perturbations developing follicles elucidate four downy-juvenile events. We report that extracellular matrix reorganization leads peripheral pulp...
The evolution of bilaterally symmetric feathers is a fundamental process leading toward flight. One major unsolved mystery how the single bird can form radially downy and flight feathers. In developing feather follicles, barb ridges are organized parallel to long axis follicle. flight-feather helically anterior region, fusion creation rachis. Here we discover an anterior–posterior molecular gradient wingless int (Wnt3)a in but not Global inhibition Wnt transforms into Production ectopic...
Branching morphogenesis is a general mechanism that increases the surface area of an organ. In chicken feathers, flat epithelial sheath at base follicle transformed into periodic branches. How exactly keratinocytes are organized this pattern remains unclear. Here we show in feather follicle, pre-branch basal have extensive filopodia, which contract and smooth out after branching. Manipulating filopodia via small GTPases RhoA/Cdc42 also regulates branch formation. These help interpret...
Complex molecular interactions dictate the developmental steps that lead to a mature and functional cornea lens. Peters anomaly is one subtype of anterior segment dysgenesis especially due abnormal development MSX2 was recently implicated as potential gene critical for development. However, role within complex mechanisms eye remains elusive. Our present study observed morphologic changes in conventional Msx2 knockout (KO) mice found phenotypes consistent with microphthalmia seen humans. The...
ABSTRACT Sensing a global directional cue to orient cell growth is crucial in tissue morphogenesis. An anterior-posterior gradient of Wnt signaling controls the helical feather branches (barbs), and thus formation bilateral feathers. However, it remains unclear how keratinocytes sense this barb growth. Here, we show that chicken, owing branching, subdivided into periodic barbs. Within each barb, anterior barbule plate cells tilt before posterior cells. The core planar polarity gene Prickle1...
Ionizing radiation (IR) is a common therapeutic agent in cancer therapy. It damages normal tissue and causes side effects including dermatitis mucositis. Here we use the feather follicle as model to investigate mechanism of IR-induced damage, because any perturbation growth will be clearly recorded its regular yet complex morphology. We find that IR induces defects formation dose-dependent manner. No abnormality was observed at 5 Gy. A transient, reversible induced 10 Gy, leading structure....
The small bowel (SB) represents the most important dose-limiting structure in pelvic radiotherapy (RT). However, we observed that majority of rectal cancer patients who received preoperative intensity modulated RT (IMRT) developed acute tenesmus without watery diarrhea. objective this study is to determine if dose SB affects lower gastrointestinal toxicity (ALGIT) neoadjuvant concurrent chemotherapy-IMRT. We will also evaluate patient and tumor factors affect ALGIT. retrospectively analyzed...
Abstract The slow-evolving invertebrate amphioxus has an irreplaceable role in advancing our understanding into the vertebrate origin and innovations. Here we resolve nearly complete chromosomal genomes of three species, one which best recapitulates 17 chordate ancestor linkage groups. We reconstruct fusions, retention or rearrangements between descendants whole genome duplications (WGDs), gave rise to extant microchromosomes likely existed ancestor. Similar vertebrates, gradually...