A5101798004- Glaucoma and retinal disorders
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Rangeland Management and Livestock Ecology
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Dermatology and Skin Diseases
- Autophagy in Disease and Therapy
- Advancements in Transdermal Drug Delivery
- Corneal surgery and disorders
- Phytochemistry and Biological Activities
- Ocular Infections and Treatments
- RNA and protein synthesis mechanisms
- Nanoparticle-Based Drug Delivery
- CRISPR and Genetic Engineering
- Peptidase Inhibition and Analysis
- Multiple Myeloma Research and Treatments
- RNA regulation and disease
- Remote Sensing and Land Use
- Healthcare and Venom Research
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Flavonoids in Medical Research
- Plant responses to water stress
Shanghai Jiao Tong University
2021-2025
Chinese Academy of Sciences
2016-2023
Hefei Institutes of Physical Science
2023
University of Science and Technology of China
2023
Zhejiang University
2017-2021
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2021
Henan Provincial Eye Hospital
2019-2021
Henan Provincial People's Hospital
2019-2021
State Key Laboratory of Plant Genomics
2016-2021
Institute of Genetics and Developmental Biology
2016-2021
GeneCodis is a web server application for functional analysis of gene lists that integrates different sources information and finds modular patterns interrelated annotations. This integrative approach has proved to be useful the interpretation high-throughput experiments therefore new version system been developed expand its functionality scope. now expands with regulatory user-defined annotations, offering possibility integrating all in same analysis. Traditional singular enrichment...
Endoplasmic reticulum-associated degradation (ERAD) is known to regulate plant responses diverse stresses, yet its underlying molecular mechanisms and links various stress signaling pathways are poorly understood. Here, we show that the ERAD component ubiquitin-conjugating enzyme UBC32 positively regulates drought tolerance in Arabidopsis thaliana by targeting aquaporins PIP2;1 PIP2;2 for degradation. Furthermore, demonstrate RING-type ligase Rma1 acts together with E2 activity of essential...
The alpine grasslands of the Qinghai–Tibet Plateau are one most famous grazing ecosystems in world, providing a variety ecosystem functions and services. rate grassland degradation has been slowed by implementation national restoration projects, but on not yet fundamentally reversed, some still degraded to varying degrees. main causes both human natural factors. Human factors include overgrazing, over-cultivation, indiscriminate digging mining, mineral resource development, infrastructure...
Significance The coreceptors of phytohormone ABA, such as ABI1, are the central regulator plant tolerance to drought and other abiotic stresses. Tight regulation ABI1 through ubiquitination is vital for ABA signaling tolerance. In this study, we identified a mechanism reduce protein levels by an E2-E3 pair UBC27–AIRP3. UBC27 directly binds cooperates with AIRP3 in degradation signaling. further activates expression , inhibits UBC27, enhances interaction between establishing positive feedback...
Abstract Sulfur‐fluoride exchange (SuFEx) reaction is an emerging class of click chemistry reaction. Owing to its efficient reactivity under physiological conditions, SuFEx used construct covalent protein drugs. Herein, a affibody‐molecular glue drug conjugate nanoagent reported, which can irreversibly bind with target through proximity‐enabled As proof concept, latent bioreactive unnatural amino acid fluorosulfate‐L‐tyrosine (FSY) first introduced at site 36 the affibody cysteine mutation...
The ubiquitin 26S proteasome (26SP) system efficiently degrades many key regulators of plant development. 26SP consists two subcomplexes: the catalytic 20S core particle (CP) and 19S regulatory (RP). Previous studies have focused on RP; whether there is a specific subunit in CP that has stress-related biological function plants unclear. PBE1, one β5 subunits Arabidopsis CP, essential for assembly proteolytic activity salt-stressed seedlings. expression PBE1 stress-induced. During transition...
During host stress response against virus infection, some animal microRNAs (miRNAs) can be upregulated to restore the virus-caused metabolic disorder of cells via suppressing expressions miRNAs' target genes. These antiviral miRNAs may have antitumor capacity, because tumorigenesis results from cells. However, this subject has not been explored. In study, showed that shrimp miR-34, which was during white spot syndrome (WSSV) had activity in shrimp. The expression miR-34 breast cancer and...
Background/aim: Estrogen is reported to promote the occurrence and development of several human cancers. Increasing evidence shows that most lung tumors exert estrogen receptor expression. In present study, we investigated underlying mechanism effect in cancer through receptor-epithelial–mesechymal-transition signaling pathways for first time. Materials methods: A total 36 inbred C57BL/6 mice (18 male 18 female) were injected subcutaneously with adenocarcinoma cell line, Lewis. After tumor...
Abstract. The effect of Land Use Change and Forestry (LUCF) on terrestrial carbon fluxes can be regarded as a credit or debit under the UNFCCC, but scientific uncertainty in estimates for LUCF remains large. Here, we assess by examining variety models different types with land cover change maps 1990s. Annual pools their changes are separated into components separate geographical regions, while annual areas disaggregated activities biospheric response due to CO2 fertilization climate change....
Globally, the loss of forests now contributes almost 20% carbon dioxide emissions to atmosphere. There is an immediate need reduce current rates forest loss, and associated release dioxide, but for many areas world these are largely unknown. The Soviet Union contained a substantial part world's fate those their effect on dynamics remain unknown former Eastern Bloc. For Georgia, political economic transitions following independence in 1991 have been dramatic. In this paper we quantify land...
Abiotic stresses often disrupt protein folding and induce endoplasmic reticulum (ER) stress. There is a sophisticated ER quality control (ERQC) system to mitigate the effects of malfunctioning proteins maintain homeostasis. The accumulation misfolded in activates unfolded response (UPR) enhance degradation mediate by ER-associated (ERAD). That ERQC reduces abiotic stress damage has been well studied mammals yeast. However, plants, both ERAD UPR have separately found be critical for plant...
Geranium wilfordii is one of the major species used as Herba Geranii (lao-guan-cao) in China, it commonly solely or polyherbal formulations for treatment joint pain resulted from rheumatoid arthritis (RA) and gout. This herb to validate a target-based drug screening platform called Herbochip® evaluate anti-inflammatory effects ethanolic extract (GWE) using tumor necrosis factor-alpha (TNF-α) target together with subsequent vitro vivo assays.A microarray-based was constructed by arraying HPLC...
More and more evidence suggests that microRNA (miRNA) RNA editing play key roles in the development progression of tumor. However, influence miRNA-mediated on tumor stem cells remains unclear. In this study, results demonstrated miR-17, which was downregulated melanoma cells, acted as a inhibitor by suppressing stemness promoting cell differentiation. MiR-17 targeted
A novel supramolecular hydrogel AD-<italic>g</italic>-HPG/CD-<italic>g</italic>-Dex based on host–guest interaction as a scaffold for cell proliferation and drug delivery.
Tumor necrosis factor-related apoptosis ligand (TRAIL) is a promising protein candidate for selective of variety cancer cells. However, the short half-life and lack targeted delivery are major obstacles its application in therapy. Here, we propose simple strategy to solve targeting problem by genetically fusing an anti-HER2 affibody C-terminus TRAIL. The fusion TRAIL-affibody was produced as soluble form with high yield recombinant Escherichia coli. In vitro studies proved that domain...