A5101798228- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Particle physics theoretical and experimental studies
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Black Holes and Theoretical Physics
- Nuclear physics research studies
- Autophagy in Disease and Therapy
- Plant Stress Responses and Tolerance
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Herpesvirus Infections and Treatments
- Plant Parasitism and Resistance
- Plant responses to water stress
- Photosynthetic Processes and Mechanisms
- Plant tissue culture and regeneration
- Pharmacological Effects of Natural Compounds
- Cold Atom Physics and Bose-Einstein Condensates
- Antifungal resistance and susceptibility
- Epigenetics and DNA Methylation
- Scientific Research and Discoveries
- Biocrusts and Microbial Ecology
- Flavonoids in Medical Research
Nanjing Forestry University
2014-2025
Zhengzhou Central Hospital
2023-2025
University of Missouri
2023-2025
Southern Medical University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Guang’anmen Hospital
2024
Zhujiang Hospital
2024
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Guangxi University of Science and Technology
2005-2022
A search for POU domain sequences expressed in the human retina has led to identification of three closely related genes: Brn-3a, Brn-3b, and Brn-3c. The structure expression pattern Brn-3b was reported earlier (Xiang et al., 1993); we report here structures patterns Brn-3a Antibodies specific each Brn-3 protein were generated shown label only ganglion cells a variety vertebrate retinas. complex strongly weakly immunolabeled observed mouse, cat, monkey retinae. In mouse cat retinae, proteins...
Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within context of obesity, lipid metabolism, adipose tissue formation, inflammation are intricately linked endoplasmic reticulum stress (ERS). ERS modulates insulin signaling, inflammation, well cell proliferation death through unfolded protein response (UPR) pathway. Serving crucial nexus, bridges functionality inflammatory...
The three members of the Brn-3 family POU domain transcription factors are found in highly restricted sets central nervous system neurons. Within retina, these present only within subsets ganglion cells. We show here that developing mouse Brn-3b protein is first observed presumptive cell precursors as they begin to migrate from zone dividing neuroblasts future layer, and targeted disruption gene leads homozygous state a selective loss 70% retinal In (-/-) mice other neurons retina brain...
Abstract Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging age-related disease, SASP-related inflammation is thought to contribute tissue dysfunction diseased animals. However, whether how SASP factors influence regenerative capacity of tissues remains unclear. Here, using intestinal organoids as a model regeneration, we show that released by senescent fibroblasts deregulate stem cell activity differentiation ultimately impair crypt...
Rice (Oryza sativa) leaf angle is determined by lamina joint and an important agricultural trait determining erectness and, hence, the photosynthesis efficiency grain yield. Genetic studies reveal a complex regulatory network of development; however, morphological changes, cytological transitions, underlying transcriptional programming remain to be elucidated. A systemic study reveals dynamic developmental process suggests common but distinct regulation joint. Successive sequential cell...
Abscisic acid (ABA), the most important stress-induced phytohormone, regulates seed dormancy, germination, plant senescence, and abiotic stress response. ABA signaling is repressed by group A type 2C protein phosphatases (PP2Cs), then binds to its receptor of ACTIN RESISTANCE1 (PYR1), PYR1-LIKE (PYL), REGULATORY COMPONENTS OF RECEPTORS (RCAR) family, which, in turn, inhibits PP2Cs activates downstream signaling. The agonist/antagonist receptors have potential reveal machinery become lead...
Leaf angle is an important agronomic trait and influences crop architecture yield. Studies have demonstrated the roles of phytohormones, particularly auxin brassinosteroids, various factors in controlling leaf inclination. However, underlying mechanism especially upstream regulatory networks still need being clarified. Here we report functional characterization rice inclination3 (LC3), a SPOC domain-containing transcription suppressor, regulating inclination through interacting with LIP1...
<title>Abstract</title> Background Therapeutic drug monitoring (TDM) of voriconazole (VCZ) was strongly recommended due to the highly variable exposure. The VCZ serum trough concentration (VCZ-<italic>C</italic><sub>min</sub>) affected by multiple factors, which made dosage adjustments more challenging. However, there is a paucity data regarding variability VCZ-<italic>C</italic><sub>min</sub> in critically ill elderly patients. Method A prospective observational study conducted at Zhengzhou...
In eukaryotic organisms, protein kinases regulate diverse activities and signaling pathways through phosphorylation of specific substrates. Isolating characterizing kinase substrates is vital for defining downstream pathways. The Kinase Client (KiC) assay an in vitro synthetic peptide LC-MS/MS that has enabled identification (i.e., clients) various kinases. For example, previous use a 2,100-member (2k) library identified the extracellular ATP receptor-like kinase, P2K1. Many P2K1 clients...
One of the most important growth factors in cannabis cultivation is light which plays a big role its successful growth. However, understanding that how controls industrial hemp and development poor needs advanced research. Therefore, pot study was conducted to investigate effects different colors light, is, white (WL), blue (BL), red (RL), 50% with mix (RBL) on morphology, gaseous exchange antioxidant capacity hemp. Compared WL, BL significantly increase terms shoot fresh biomass (15.1%),...
Developing peptide-based tools to fine-tune growth signaling pathways, in particular molecules with exquisite selectivity and high affinities, opens up opportunities for cellular reprogramming tissue regeneration. Here, we present a library based on cystine-knot peptides (CKPs) that incorporate multiple loops randomization selection via directed evolution. Resulting binders could be assembled into multimeric structures signaling. An example is presented the Wnt pathway, which plays key role...
Breast cancer is the most common cause of cancer-related death among women, and prognosis especially poor for patients with triple-negative breast (TNBC); therefore, there an urgent need new effective therapies. Recent studies have demonstrated that uracil auxotroph Toxoplasma gondii vaccine displays anti-tumor effects. Here, we examined immunotherapy effects attenuated strain T. against 4T1 murine cancer.We constructed a RH via orotidine 5'-monophosphate decarboxylase gene deletion...
Background/aim: Estrogen is reported to promote the occurrence and development of several human cancers. Increasing evidence shows that most lung tumors exert estrogen receptor expression. In present study, we investigated underlying mechanism effect in cancer through receptor-epithelial–mesechymal-transition signaling pathways for first time. Materials methods: A total 36 inbred C57BL/6 mice (18 male 18 female) were injected subcutaneously with adenocarcinoma cell line, Lewis. After tumor...
Toxoplasma gondii rhoptry protein ROP18 (TgROP18) is a key virulence factor secreted into the host cell during invasion, where it modulates response by interacting with its targets. However, only few TgROP18 targets have been identified. In this study, we applied high-throughput protein-protein interaction (PPI) screening in human cells using bimolecular fluorescence complementation (BiFC) to identify of Type I strain (ROP18I) and II (ROP18II). From pool more than 18,000 proteins, 492 141...
Toxoplasma gondii is an opportunistic protozoan, which widely infects humans and other warm-blooded animals. The type I interferon (IFN) such as IFN-α/β involved in cGAS-STING signaling to resist T. infection. We found RAW264.7 cells, that virulence factor TgROP18I, inhibited IFN-β production through interacting with regulatory 3 (IRF3). Besides, TgROP18I interacted p62 Tumor Necrotic Factor Receptor Associated 6 (TRAF6), resulted the inhibition of TRAF6-p62 interaction, phosphorylation p62....
Drought (Water deficit, WD) poses a serious threat to extensively economic losses of trees throughout the world. Chinese dwarf cherry (Cerasus humilis) is good perennial plant for studying physiological and sophisticated molecular network under WD. The aim this study identify effect WD on C. humilis through global proteomics analysis improve understanding resistance plants. Currently, parameters were applied investigate response Moreover, we used two-dimensional gel electrophoresis (2DE)...
The obligate intracellular parasite, Toxoplasma gondii, manipulates the cytoskeleton of its host cells to facilitate infection.A significant rearrangement cell vimentin around parasitophorous vacuoles is observed during course infection.ROP18 (TgROP18) a serine-threonine kinase secreted by T. gondii rhoptry and major virulence factor; however, mechanisms which this modulates factors remain poorly understood.Different dynamic patterns solubility, phosphorylation, expression levels were in...
Abstract Identification and characterization of soybean germplasm gene(s)/allele(s) for salt tolerance is an effective way to develop improved varieties saline soils. Previous studies identified GmCHX1 (Glyma03g32900) as a major gene in soybean, two main functional variations were found the promoter region (148/150 bp insertion) third exon with retrotransposon insertion (3.78 kb). In current study, we four salt-tolerant lines, including PI 483460B (Glycine soja), carrying previously...
Fatty acid binding protein 3 (FABP3, also termed heart‑type fatty protein) is a member of the intracellular lipid‑binding family that may be essential in transport, cell growth, cellular signaling and gene transcription. Previously, we demonstrated FABP3 was involved apoptosis‑associated congenital cardiac malformations; however, its mechanism regulation remains unclear. Apoptosis has increasingly been considered to important development. In present study, zebrafish model used investigate...