A5101406968- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Genetic diversity and population structure
- Identification and Quantification in Food
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Effects of Environmental Stressors on Livestock
- Environmental Toxicology and Ecotoxicology
- Ichthyology and Marine Biology
- MicroRNA in disease regulation
- Fish Biology and Ecology Studies
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Mollusks and Parasites Studies
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Extracellular vesicles in disease
Ruijin Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Shaoxing People's Hospital
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2023-2024
Wuhan University
2024
Georgia Institute of Technology
2024
Guangdong Ocean University
2024
Shenzhen University Health Science Center
2024
Chinese Academy of Fishery Sciences
2009-2023
Cancer-associated Fibroblasts (CAFs) exert a tumor-promoting effect in various cancers, including breast cancer. CAFs secrete exosomes containing miRNA and proteins, influencing the tumor microenvironment. In this study, we identified CAF-derived that transport functional miR-92a from to cells, thereby intensifying aggressiveness of downregulate expression G3BP2 cancer significant elevation levels was observed. Both vitro vivo experiments demonstrate enhances cell migration invasion by...
Stroke poses a significant risk of mortality, particularly among the elderly population. The pathophysiological process ischemic stroke is complex, and it crucial to elucidate its molecular mechanisms explore potential protective drugs. Ferroptosis, newly recognized form programmed cell death distinct from necrosis, apoptosis, autophagy, closely associated with pathophysiology stroke. N6022, selective inhibitor S-nitrosoglutathione reductase (GSNOR), "first-in-class" drug for asthma...
Phospholipase C-γ1 (PLC-γ1) is rapidly activated in response to growth factor stimulation and plays an important role regulating cell proliferation differentiation through the generation of second messengers diacylglycerol inositol 1,4,5-trisphosphate, leading activation protein kinase C (PKC) increased levels intracellular calcium, respectively. Given existing overlap between signaling pathways that are oxidant injury those involved responding proliferative stimuli, we investigated PLC-γ1...
Immune profile of B and T cells tertiary lymphoid structures (TLSs) may differ in tumors lung cancer (LC) patients with/without chronic obstructive pulmonary disease (COPD), also influence patient survival. We sought to analyze: (1) TLSs, germinal centers (GCs), cells, (2) associations the immune biomarkers with patients’ 10-year overall survival (OS). TLSs (numbers area), [cluster differentiation (CD) 20], (CD3), GCs were identified both tumor non-tumor specimens (thoracotomy) from 90...
The aim of the present study was to examine effect high temperature on cecal microbiota laying hens and analyze correlation between variation in feed intake, body temperature, relative abundance specific bacterial genera. Two hundred sixteen 28-wk-old Hy-Line were randomly divided into 3 groups with 6 replicates raised controlled climate chambers. Birds allocated either a thermoneutral group (TC, 21 ± 1°C, ad libitum), cyclic (HT, 29-35°C, or pair-feeding (PF, daily intake HT hens) for 4 wk....
Smart corrosion inhibitor systems have been hot research topic in recent years. Compared with conventional inhibitors or coatings, can be released according to specific task achieves more...
Introduction To explore the associations between blood urea nitrogen-to-creatinine ratio (BCR), acute kidney injury (AKI), and in-hospital mortality in coronavirus disease 2019 (COVID-19) patients.
Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according were assessed using biostatistical approach large cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 906 patients who met inclusion criteria clustered into two groups on basis of their levels. potential differences severity index (BSI) score...
Background BRAF mutation is one of the most common genetic alterations contributing to initiation and progression papillary thyroid carcinoma (PTC). However, prognostic value for PTC limited. Novel markers are needed identify BRAF-mutant patients with poor prognosis. Methods Transcriptional expression data were downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) datasets. Pathway enrichment was performed by Kyoto Encyclopedia Genes Genomes (KEGG) analysis gene set...
Breast cancer poses a huge threat to the lives and health of women worldwide. However, drug resistance makes treatment breast challenging. This study aims investigate effect miR-141-3p on paclitaxel its underlying mechanisms in cancer.
As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that (upper lower limbs) function nutritional status be more significantly altered female than males for identical age disease severity. In mild-to-moderate (
Evidence from anatomical, pharmacological, and genetic studies supports a role for the neuropeptide melanin concentrating hormone system in modulating emotional cognitive functions. Genome-wide association revealed potential between receptor (MCHR1) gene locus schizophrenia, largest genome-wide study conducted to date shows credible association.We analyzed MCHR1 pro-melanin RNA-Seq expression prefrontal cortex schizophrenia patients healthy controls. Disruptions were modeled mouse brain by...
Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that profile characterized by T regulatory (Treg), natural killer (NK), and plasma cells, as well interleukin (IL)-10 interferon-gamma, may differ within tumors of LC patients with/without COPD. Methods: Treg (anti-CD3 anti-forkhead boxP3 antibodies), NK (anti-NCR1 antibody), IgG (anti-CD138-IgG IgA...
Fatty acid binding protein 3 (FABP3, also termed heart‑type fatty protein) is a member of the intracellular lipid‑binding family that may be essential in transport, cell growth, cellular signaling and gene transcription. Previously, we demonstrated FABP3 was involved apoptosis‑associated congenital cardiac malformations; however, its mechanism regulation remains unclear. Apoptosis has increasingly been considered to important development. In present study, zebrafish model used investigate...
We sought to investigate differential phenotypic characteristics according neutrophil counts, using a biostatistics approach in large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met inclusion criteria were clustered into two groups on basis of their blood levels. Using Mann–Whitney U test explore potential differences FACED and EFACED scores between groups, count 4990 cells/µL yielded most balanced cluster sizes: (1) above-threshold (n = 337)...