A5029008574- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Gout, Hyperuricemia, Uric Acid
- Metabolism, Diabetes, and Cancer
- Pediatric health and respiratory diseases
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Lung Cancer Diagnosis and Treatment
- NF-κB Signaling Pathways
- Respiratory viral infections research
- Lung Cancer Treatments and Mutations
- Inflammasome and immune disorders
- Protein Tyrosine Phosphatases
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Metastasis and carcinoma case studies
- Protein Kinase Regulation and GTPase Signaling
University of Science and Technology of China
2023
Nanchang University
2020-2022
Universitat Pompeu Fabra
2021-2022
Universitat Autònoma de Barcelona
2021-2022
Parc de Salut
2021-2022
First Affiliated Hospital of Nanchang University
2020-2022
Barcelona Biomedical Research Park
2021-2022
Municipal Institute for Medical Research
2022
Soochow University
2015
Abstract Activation of adenosine monophosphate-activated protein kinase (AMPK) is able to produce significant anti-non-small cell lung cancer (NSCLC) activity. ASP4132 an orally active and highly effective AMPK activator. The current study tested its activity against NSCLC cells. In primary cells established lines (A549 NCI-H1944) potently inhibited growth, proliferation cycle progression as well migration invasion. Robust apoptosis activation was detected in ASP4132-treated Furthermore,...
The expression and biological function of the mitochondrial inner membrane protease YME1L (YME1 Like 1 ATPase) in NSCLC are tested here. Bioinformatical analyses results from local human tissues show that is elevated tissues. upregulation was observed primary immortalized cells. In cells, shRNA-mediated silence or dCas9/sgRNA-induced knockout (KO) robustly suppressed cell growth migration, provoking apoptosis. shRNA/KO resulted dysfunctions leading to depolarization, ROS accumulation ATP...
In non-small-cell lung carcinoma (NSCLC), aberrant activation of mammalian target rapamycin (mTOR) contributes to tumorigenesis and cancer progression. PQR620 is a novel highly-potent mTOR kinase inhibitor. We here tested its potential activity in NSCLC cells. primary human cells established cell lines (A549 NCI-H1944), inhibited growth, proliferation, cycle progression, as well migration invasion, while inducing significant apoptosis activation. disrupted assembles complex 1 (mTOR-Raptor) 2...
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations are responsive to EGFR-tyrosine kinase inhibitor (EGFR-TKI). However, NSCLC secondary somatic EGFR resistant EGFR-TKI treatment. In this study, we investigated the effect of TG101348 (a JAK2 inhibitor) on tumor erlotinib-resistant cells. Cell proliferation, apoptosis, gene expression and were evaluated by diphenyltetrazolium bromide (MTT) assay, flow cytometry, terminal deoxynucleotidyl...
Abstract The purpose of this study is to explore the antitumor properties resibufogenin (RB) in non‐small cell lung cancer (NSCLC) and elucidate its underlying mechanism. A549 H520 cells were treated with various concentrations RB or without NLRP3 inhibitor (MCC950), caspase‐1 (VX765), N ‐acetyl‐ l ‐cysteine (an ROS scavenger). Cell counting kit‐8 colony formation assays conducted determine viability. invasion was detected by using transwell assay. release lactate dehydrogenase (LDH)...
As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that (upper lower limbs) function nutritional status be more significantly altered female than males for identical age disease severity. In mild-to-moderate (
We hypothesized that in mild bronchiectasis patients, increased systemic inflammation and redox imbalance may take place correlate with clinical parameters. In plasma samples from patients very bronchiectasis, inflammatory cells molecules balance parameters were analyzed. the lung function exercise capacity, nutritional status, bacterial colonization, radiological extension assessed. Correlations between biological variables determined. Compared to healthy controls, levels of acute phase...
Objective: To investigate the effect of high expression XAF1 in vivo or vitro on lung cancer cell growth and apoptosis. Methods: 1. The A549 human line was transfected with Ad5/F35 - XAF1, Null at same multiplicity infection (MOI); (hereinafter referred to as transient strain); gene mRNA protein detected by reverse transcription polymerase chain reaction (RT-PCR) Western blotting respectively. 2. Methyl thiazolyl tetrazolium (MTT) annexin V-FITC/PI double staining were used detect...
Whether the COVID-19 pandemic may have modified clinical planning and course in bronchiectasis patients remains to be fully elucidated. We hypothesized that influenced management outcomes of who were followed up for 12 months. In (n = 30, 23 females, 66 years), lung function testing, disease severity [FEV1, age, colonization, radiological extension, dyspnea (FACED), exacerbation (EFACED)] scores, numbers hospitalizations, body composition, sputum microbiology, blood analytical biomarkers...
Epithelial–mesenchymal transition (EMT) is involved in the pathophysiology of lung cancer (LC) and COPD, latter an important risk factor for LC. We hypothesised that EMT gene expression profile signalling cascade may differ LC patients with COPD from those no respiratory diseases. In tumour specimens obtained through video-assisted thoracoscopic surgery (n=20, control group) LC-COPD (n=30), (quantitative real-time PCR amplification) markers SMAD3 , SMAD4 ZEB2 TWIST1 SNAI1 ICAM1 VIM CDH2 MMP1...