A5101931662- Mosquito-borne diseases and control
- RNA modifications and cancer
- Enzyme Production and Characterization
- Viral Infections and Vectors
- Cancer-related molecular mechanisms research
- Antifungal resistance and susceptibility
- Protein Hydrolysis and Bioactive Peptides
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Acupuncture Treatment Research Studies
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Tuberculosis Research and Epidemiology
- Medical Research and Treatments
- Mycobacterium research and diagnosis
- Circular RNAs in diseases
- Phytochemistry and Biological Activities
- Metabolism, Diabetes, and Cancer
- Cancer-related gene regulation
- Endometrial and Cervical Cancer Treatments
- Infectious Diseases and Mycology
- Neonatal Respiratory Health Research
- Malaria Research and Control
Peking University People's Hospital
2023-2025
Peking University
2023-2025
First Affiliated Hospital of Henan University
2025
Qilu Hospital of Shandong University
2023-2024
Capital Medical University
2023-2024
Beijing Chest Hospital
2023-2024
Chengdu University
2024
Wuhan University
2011-2023
Jiangsu University
2021-2023
Wuhan Institute of Virology
2013-2023
Neuroligin-3 (NLGN3) is necessary and sufficient to promote glioma cell growth.The recruitment of Gαi1/3 the ligand-activated receptor tyrosine kinases (RTKs) essential for mediating oncogenic signaling.Methods: Various genetic strategies were utilized examine requirement in NLGN3-driven growth.Results: NLGN3-induced Akt-mTORC1 Erk activation was inhibited by decreasing expression.In contrast ectopic overexpression enhanced signaling.In cells, growth, proliferation migration attenuated...
The expression and biological function of the mitochondrial inner membrane protease YME1L (YME1 Like 1 ATPase) in NSCLC are tested here. Bioinformatical analyses results from local human tissues show that is elevated tissues. upregulation was observed primary immortalized cells. In cells, shRNA-mediated silence or dCas9/sgRNA-induced knockout (KO) robustly suppressed cell growth migration, provoking apoptosis. shRNA/KO resulted dysfunctions leading to depolarization, ROS accumulation ATP...
To observe and evaluate the effectiveness safety of Bushen Tongdu (reinforcing kidney-yang regulating Governor Vessel) external treatment for patients with deficiency type ankylosing spondylitis (AS). Patients Kidney-yang AS were randomly divided into an observation group(36 cases, 4 cases dropped out) a control 3 out). The group received which was combination Ren Du Zhou-Tian moxibustion acupoint embedding therapy, i.e. performing ginger-juice soaked nonwoven separated first at back...
Background Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinological and metabolic disorder which the common cause of female infertility. The dysmetabolism displayed in it has not been completely ascertained. Metabonomics may shed light on understanding many small molecule endogenous metabolites their associated pathways. Objective To analyze different related pathways follicular fluid embryo culture PCOS non-PCOS groups. Finding markers predictable for clinical outcomes vitro...
Folium isatidis is a native Chinese herbaceous plant widely used for medicinal purposes thousands of years. However, few studies have focused on the leaves Isatis indigotica. In this report, we isolated series four fractions (I–IV) from and explored antiviral activity each tested extract. The extracts were active against panel RNA DNA viruses in vitro, namely influenza A virus (IAV), coxsackie B3 (CVB3), respiratory syncytial (RSV), adenovirus type 7 (Ad-7). Oral administration 200 mg/kg/d...
Background Sarcopenia is a common complication of liver cirrhosis and can be used for predicting dismal prognostic outcomes. This study aimed to evaluate the role sarcopenia in rebleeding mortality patients after endoscopic therapy.
Patients with ovarian cancer who receive platinum-based chemotherapy typically develop platinum resistance, which leads to tumor recurrence and mortality. Therefore, finding the underlying mechanisms biomarkers is critical. A total of 51 platinum-resistant 70 platinum-sensitive patients were enrolled in this study. We examined GSE131978 dataset National Center for Biotechnology Information (NCBI) Gene Expression Omnibus database differentially expressed long non-coding RNAs messenger (mRNAs)...
Abstract Fetal development and parturition are precisely regulated processes that involve continuous crosstalk between the mother fetus. Our previous discovery wild‐type mice carrying steroid receptor coactivator (Src)‐1 Src‐2 double‐deficient fetuses exhibit impaired lung delayed labor, which indicates signals for emanate from In this study, we perform RNA sequencing targeted metabolomics analyses of lungs fetal Src‐1 / ‐2 double‐knockout find expression arginase 1 (Arg1) is significantly...
We sought to characterize dengue virus (DENV) infections among febrile children enrolled in a pediatric cohort study who were clinically diagnosed with non-dengue illness ("C cases"). DENV detected and viral load quantitated by real-time reverse transcription-polymerase chain reaction C cases presenting between January 2007 2013. One hundred forty-one of 2892 (4.88%) tested positive for DENV. Of all the study, DENV-positive accounted an estimated 52.0% patients viremia at presentation....
IntroductionMitochondrial fission process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein implicated in the development and progression of various tumors, particularly lung squamous cell carcinoma (LUSC). This study aims to provide a more theoretical basis for treatment LUSC.MethodsThrough bioinformatics analysis, MTFP1 was identified as novel target gene HIF1A. expression LUSC examined using The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Proteomics Data Commons...
Osteosarcoma (OS) is a common primary bone malignancy. We here investigated the potential activity of PF-06409577, novel, potent, and direct activator AMP-activated protein kinase (AMPK), against human OS cells. In established (U2OS, MG-63, SaOs-2 lines) cells, PF-06409577 inhibited cell viability proliferation, while inducing apoptosis cycle arrest. induced AMPK activation, mTORC1 inhibition, autophagy induction, downregulation multiple receptor tyrosine inOS inactivation by α 1 shRNA,...
Emerging evidence has shown that microRNA (miR)‑497 serves pivotal roles in tumorigenesis, cancer progression, metastasis and chemotherapy resistance several types of cancer. In the present study, expression biological functions miR‑497 host gene (MIR497HG) were investigated glioma tissue. The levels MIR497HG measured glioma, adjacent non‑cancerous normal brain tissue their association with prognosis patients analyzed. cell lines. addition, bioinformatics analysis, luciferase reporter assay...
Experiments were carried out to investigate the effects of various factors on activity and conformation recombinant leucine aminopeptidase Bacillus kaustophilus CCRC 11223 (BkLAP) potential utilization BkLAP in hydrolysis anchovy protein. Optimal temperature pH 70 °C 8.0 potassium-phosphate buffer, respectively, was strongly stimulated by Ni2+, followed Mn2+ Co2+. Conformational studies via circular dichroism spectroscopy indicated that could influence secondary structure different extents...