A5080859269- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Micro and Nano Robotics
- Advanced Polymer Synthesis and Characterization
- Cancer, Hypoxia, and Metabolism
- Dendrimers and Hyperbranched Polymers
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Neuroblastoma Research and Treatments
- CAR-T cell therapy research
- Molecular Communication and Nanonetworks
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- Acute Lymphoblastic Leukemia research
- Nerve injury and regeneration
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Natural Compound Pharmacology Studies
- Neonatal Respiratory Health Research
- Graphene and Nanomaterials Applications
- Additive Manufacturing and 3D Printing Technologies
Chengdu University
2019-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Huaqiao University
2019-2021
Southwest Jiaotong University
2013-2019
It is one of the challenges for a wide clinical application polymer micelles to address structure disintegration and premature drug release before reaching pathological site. In current study, folic acid (FA)-decorated polymer–drug conjugates (FSC) were synthesized with disulfide linkages between camptothecin (CPT) amphiphilic poly(ethylene glycol)-b-poly(ε-caprolactone) (PECL) copolymers. FSC proposed assemble into hydrophobic core PCL segments CPT hydrophilic corona PEG segments. The...
"Turn-on" or "turn-off" probes remain challenges in the establishment of sensitive, easily operated, and reliable methods for situ monitoring bioactive substances. In current study, electrospun fibrous strips are designed to provide straightforward observations ratiometric color changes with naked eye presence serum heparin urine trypsin. A tetraphenylethene (TPE) derivative is constructed along phloxine B grafted on fibers, followed by protamine adsorption induce static quenching...
Abstract Recently, hydrogels have gained enormous interest in three-dimensional (3D) bioprinting toward developing functional substitutes for tissue remolding. However, it is highly challenging to transmit electrical signals cells due the limited conductivity of bioprinted hydrogels. Herein, we demonstrate 3D bioprinting-assisted fabrication a conductive hydrogel scaffold based on poly-3,4-ethylene dioxythiophene (PEDOT) nanoparticles (NPs) deposited gelatin methacryloyl (GelMA) enhanced...
The interplay between cells and their microenvironments plays a pivotal role in
Abstract The extracellular matrix (ECM) engages in regulatory interactions with cell surface receptors through its constituent proteins and polysaccharides. Therefore, nano‐sized conjugated doxorubicin (DOX) is utilized to produce matrix‐drug conjugates (ECM‐DOX) tailored for targeted delivery cancer cells. ECM‐DOX nanoparticles exhibit rod‐like morphology, boasting a commendable drug loading capacity of 4.58%, coupled acid‐sensitive release characteristics. Notably, enhance the uptake by...
Delivering the anti-inflammatory dexamethasone in nanoformulations is important for reducing off-target effects when treating rheumatoid arthritis. Nanoformulations can be targeted to sites of inflammation by modifying nanoparticles with albumin before administration, but such particles unstable vivo. Here, we have developed and validated an alternative targeting which dexamethasone-loaded liposomes were modified a 46-residue peptide called "albumin-binding domain", that would adsorb...
The tumor accumulation of micelles is essential to enhance the cellular uptake and extend release chemotherapeutic agents. In previous study camptothecin (CPT)-conjugated (MCPT) were constructed with disulfide linkages folate moieties for reduction-sensitive cell-selective uptake. This proposes a strategy integrate promicelle polymers (PMCPT) into fiber fragments intratumoral injection, realizing acid-liable PMCPT in response acidic microenvironment spontaneous self-assembly MCPT....
Cancer chemotherapy is confronted with difficulties enhancing the tumor accumulation, improving bioavailability, and relieving adverse effect of chemotherapeutic agents. To address challenges, this study proposes a feasible strategy to realize sustained release drug-loaded micelles from fiber fragments after intratumoral injection. Camptothecin (CPT) grafted on hyaluronic acid (HA) via 3,3′-dithiodipropionic obtain reduction-sensitive promicelle polymers (PMCPT), which are conjugated...
In acute lung injury, destruction of the endothelial glycocalyx leads to vessel permeabilization and contributes pulmonary edema inflammation. Heparan sulfate, which accounts for >70% glycosaminoglycans in glycocalyx, plays a crucial physiological anti-inflammatory role. To treat it is explored whether two-step vivo bioorthogonal chemistry strategy can covalently link intravenously administered heparan sulfate vascular endothelium damaged glycocalyx. First, fusogenic liposomes (EBP-Tz-FLs)...
The term synergism means that the overall therapeutic benefits should be greater than sum of effects individual agents and optimal efficacy can achieved at reduced doses.
A special microenvironment called the "pre-metastatic niche" is thought to help primary tumor cells migrate new tissues and invade them, in part because normal barrier function of vascular endothelium compromised. While itself can promote creation such niches by secreting pro-metastatic factors, underlying molecular mechanisms are still poorly understood. Here, we show that injection tumor-secreted factors from B16F10 melanoma or 4T1 breast cancer into healthy mice induce destruction...