A5004854696- Advanced machining processes and optimization
- Gear and Bearing Dynamics Analysis
- Machine Fault Diagnosis Techniques
- Structural Health Monitoring Techniques
- Traditional Chinese Medicine Analysis
- Adversarial Robustness in Machine Learning
- Endoplasmic Reticulum Stress and Disease
- Diabetes and associated disorders
- Plant-based Medicinal Research
- Pancreatic function and diabetes
- Advanced Machining and Optimization Techniques
- Tunneling and Rock Mechanics
- Pharmacological Effects of Natural Compounds
- Industrial Vision Systems and Defect Detection
- Long-Term Effects of COVID-19
- Structural Integrity and Reliability Analysis
- Advanced Measurement and Metrology Techniques
- Rock Mechanics and Modeling
- Mechanical stress and fatigue analysis
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- Engineering Diagnostics and Reliability
- Bioinformatics and Genomic Networks
- Autophagy in Disease and Therapy
- Andrographolide Research and Applications
Guang’anmen Hospital
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
China Academy of Chinese Medical Sciences
2024
Xinjiang University
2024
Tianjin University
2020-2024
Rio Tinto (Australia)
2023
Obesity presents a significant global health challenge, increasing the susceptibility to chronic conditions such as diabetes, cardiovascular disease, and hypertension. Within context of obesity, lipid metabolism, adipose tissue formation, inflammation are intricately linked endoplasmic reticulum stress (ERS). ERS modulates insulin signaling, inflammation, well cell proliferation death through unfolded protein response (UPR) pathway. Serving crucial nexus, bridges functionality inflammatory...
Non-alcoholic fatty liver disease (NAFLD) constitutes the most prevalent chronic worldwide. Progression to non-alcoholic steatohepatitis (NASH), immune cell reservoir within undergoes remodeling, exacerbating inflammation and potentially leading fibrosis. Jiangtang Qingre Formula (JQF) is an effective prescription for clinical treatment of NAFLD. However, its underlying mechanism action remains unclear. Using a high-fat diet-induced NAFLD mouse model, we evaluated JQF's effects with...
Abstract A double modulation phenomenon is found in wind turbine gearbox compound fault signals, consisting of a resonance frequency band and an asymmetric band. The modal aliasing the phenomena make it difficult to use empirical wavelet transform obtain spectral components meshing regions. Our main contribution establish optimal (OEWT) framework for weak feature extraction faults, which incorporates velocity synchronous linear chirplet (OVSLCT) simulated annealing (SA) algorithm parameters...
The integrity of cloud-based convolutional neural network (CNN) prediction services can be jeopardized by a malicious cloud server. Although zero-knowledge proof approaches used to verify integrity, they are difficult use for larger CNN models like LeNet-5 and VGG16, due the large cost (in terms time storage) generating proof. This paper proposes ValidCNN, which efficiently generate proofs based zk-SNARK. At heart it is novel usage Freivald's concepts circuit construction, more efficient way...
<title>Abstract</title> BACKGROUND Acute respiratory distress syndrome (ARDS) is a common acute clinical of the system with high mortality rate and difficult prognosis.COVID-19 serious infectious disease caused by coronaviruses in global pandemic. Some studies have suggested possible association between COVID-19 ARDS, but few investigated mechanism interaction them. METHODS Microarray data ARDS (GSE32707 GSE66890) (GSE213313) were downloaded from GEO database searched for differential genes...
Background : Huashi Baidu granule (HSBD), an approved herbal formula for treating COVID-19, demonstrates safety and efficacy. Despite its market approval, the detailed methodology identification of active components remain unexplored, leaving bioactive constituents action mechanisms unclear. Methods This study investigated potential HSBD’s ingredient in COVID-19. Our approach integrated various techniques, including GEO database, network pharmacology, surface plasmon resonance, molecular...
Huashi Baidu granule (HSBD), an approved herbal formula for treating COVID-19, demonstrates safety and efficacy. Despite its market approval, the detailed methodology identification of active components remain unexplored, leaving bioactive constituents action mechanisms unclear. This study investigated potential HSBD's ingredient in COVID-19. Our approach integrated various techniques, including UHPLC-QqQ-MS/MS method, analysis GEO database, network pharmacology, surface plasmon resonance,...
<title>Abstract</title> Objective: This study aims to utilize the Dynamic Network Biomarkers (DNB) approach identify tipping point or critical period as well leading biomarkers before transition process from prediabetes type 2 diabetes (T2D). Research design and methods: A dynamic timeline of T2D progression was constructed, ranging normal state (A) through (B-E) (F). The DNB method employed criticalstate/period its associated using proteomics data. one-year follow-up conducted validate such...
<title>Abstract</title> Tool wear status seriously affects the dimensional accuracy and surface quality of machined parts. Therefore, tool condition monitoring (TCM) is essential in milling process aerospace structural parts due to use difficult-to-cut materials complex cutting trajectories. The Higher order spectrum (HOS) was first employed analyze vibration signals, then bispectral features extracted from de-noised signals were used characterize status. improved Pearson’s correlation...
In the degradation evaluation process of crane girder structure under moving loads, complex vibration response and low accuracy health index standards are main factors limiting performance method. A method for identifying evaluating damage to structures loads has been proposed. this method, empirical wavelet transform (EWT) is optimized decomposing signal obtain sensitive components. indicator based on power spectrum maximum sequence was constructed by combining structural simulation...
In block cave mines, the permanent life of mine tunnels are required to withstand multiple changes in ground stresses and remain functional for up several decades.In general, originate from initial induced during chamber excavations.Following this is an increase abutment due undercut front advancement phase.Further occurs growth upward propagation.Then, stress reduction takes place breakthrough surface.It should be noted that at some may material re-compaction or remnant pillar loading if...
Chatter that occurs between a cutting tool and workpiece greatly reduces the surface quality production efficiency. Therefore, it is of great importance to predict avoid chatter so as guarantee stability manufacturing process. To realise accurate prediction boundary machine tools, operational modal analysis (OMA) increasingly receiving attention due its adequate consideration variations in working conditions industrial environment. However, because influence harmonic components response...