A5024220693- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Reproductive Physiology in Livestock
- Dietary Effects on Health
- Diet and metabolism studies
- Berberine and alkaloids research
- Ruminant Nutrition and Digestive Physiology
- Exercise and Physiological Responses
- Connective tissue disorders research
- Pulmonary Hypertension Research and Treatments
- Ginger and Zingiberaceae research
- Diet, Metabolism, and Disease
- Mesenchymal stem cell research
- Cardiac pacing and defibrillation studies
- Breast Lesions and Carcinomas
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Effects of Environmental Stressors on Livestock
- Plant-based Medicinal Research
- Circadian rhythm and melatonin
- Proteins in Food Systems
- Sirtuins and Resveratrol in Medicine
- Medicinal Plant Research
Chifeng University
2025
The University of Melbourne
2024
Nanjing Forestry University
2024
Northeast Agricultural University
2023
Beijing University of Chinese Medicine
2018-2023
China Medical University
2023
Huazhong University of Science and Technology
2022
Central Hospital of Wuhan
2022
The incidence of type 1 diabetes mellitus (T1DM) is increasing year by year, gut microbiota considered to be closely related the occurrence and development T1DM in recent years. In this study, Sprague Dawley (SD) rats were intraperitoneally injected with 75mg/kg streptozotocin establish model, fecal samples collected DNA extracted, 16S rRNA microbial gene clone library constructed, lastly high-throughput sequencing bioinformatics analysis performed. results showed that abundances pathogenic...
The activation of thermogenic programs in brown adipose tissue (BAT) and white (WAT) provides a promising approach to increasing energy expenditure during obesity diabetes treatment. Although evidence has been found that rutin activates BAT against type 2 mellitus (T2DM), its potential mechanism is not completely understood. In this study, we focused on the modulating effect short-chain fatty acids (SCFAs) thermogenesis WAT, aiming elucidate molecular treatment T2DM. results showed could...
<title>Abstract</title> Background Therapeutic drug monitoring (TDM) of voriconazole (VCZ) was strongly recommended due to the highly variable exposure. The VCZ serum trough concentration (VCZ-<italic>C</italic><sub>min</sub>) affected by multiple factors, which made dosage adjustments more challenging. However, there is a paucity data regarding variability VCZ-<italic>C</italic><sub>min</sub> in critically ill elderly patients. Method A prospective observational study conducted at Zhengzhou...
Background Adipose tissue (e.g. white, brown and brite) plays a critical role in modulating energy metabolism. Activating adipose (BAT) inducing browning white (WAT) has been proposed to be potential molecular target for obesity treatment. Emodin is natural anthraquinone derivative that exhibits variety of pharmacologic effects including lowering lipids regulating glucose utilization. However, the underlying mechanism action still unclear. In present study, we investigated whether emodin...
The incidence of liver-related complications in type 2 diabetes mellitus (T2DM) is rapidly increasing, which affects the physical and mental health T2DM patients. Mulberry leaf flavonoids (MLF) were confirmed to have certain effects on lowering blood glucose anti-inflammation. In this study, high-fat diet (HFD) + STZ method was used establish rat model MLF administered by gavage for eight weeks. During experiment, body weight level measured at different time points. pathological changes...
Background: Diabetic cardiomyopathy (DCM) is considered to be a distinct clinical entity independent of concomitant macro- and microvascular disorders, which initiated partly by disturbances in energy substrates. This study was observe the dynamic modulations berberine DCM rats explore changes lipidomic profiles myocardial tissue. Methods: Sprague-Dawley (SD) were fed high-sucrose high-fat diet (HSHFD) for totally 22 weeks intraperitoneally (i.p.) injected with 30 mg/kg streptozotocin (STZ)...
The current epidemic of type 2 diabetes mellitus (T2DM) significantly affects human health worldwide. Activation brown adipocytes and browning white are considered as a promising molecular target for T2DM treatment. Mulberry leaf, traditional Chinese medicine, has been demonstrated to have multi-biological activities, including anti-diabetic anti-inflammatory effects. Our experimental results showed that mulberry leaf alleviated the disorder glucose lipid metabolism in rats. In addition,...
Lipopolysaccharides (LPS) can disrupt the barrier function of mammary epithelial cells, leading to mastitis. The protective effects melatonin (MT) have been demonstrated against various infections, but underlying mechanism remains unclear in LPS-induced bovine This study, therefore, aimed investigate modulatory effect on inflammation cells (BMECs), its influence disruption circadian rhythms triggered by this inflammation, and potential molecular mechanisms. BMECs extracted from lactating...
To determine the effects of a high-fat diet (HFD) on gut microbiome in rats, to explore relationship between intestinal flora and blood lipid profile. Sprague–Dawley rats were fed an HFD for four weeks induce hyperlipidemia, then 16S rRNA sequencing was used compare hyperlipidemic control diet-fed rats. The differed from that Bacterial species less abundant most affected by feeding, among which many pathogenic species, became significantly more abundant. Eighteen genera present different...
The purpose of this study is to investigate the relationship between susceptibility type 2 diabetes and gut microbiota in rats explore potential mechanism involved.Thirty-two SPF-grade SD were raised as donor rats, divided into control, mellitus (T2DM, fasting blood glucose ≥ 11.1 mmol/L), Non-T2DM (fasting < mmol/L) groups. Feces collected prepared fecal bacteria supernatants Diab (fecal supernatant T2DM group rats), Non Con control rats). Another seventy-nine separated normal saline (NS)...
The aim of the study was to improve pre‐operative diagnosis mammary mucinous lesions. All lesions detected by fine needle aspiration (FNA) and confirmed histological examination were reviewed cytological findings, mammographic appearances sonographic findings. Twenty aspirates had corresponding pathology, including 12 carcinomas, two mucocele‐like (MLL) with atypical ductal hyperplasia, three MLL hyperplasia simple MLL. Simple showed scant cellularity, no or rare intact single tumour cells,...
Mulberry (Morus alba L.) leaf, as a medicinal and food homologous traditional Chinese medicine, has clear therapeutic effect on type 2 diabetes mellitus (T2DM), yet its underlying mechanisms have not been totally clarified. The study aimed to explore the mechanism of mulberry leaf in treatment T2DM through tandem mass tag (TMT)-based quantitative proteomics analysis skeletal muscle.The anti-diabetic activity extract (MLE) was evaluated by using streptozotocin-induced diabetic rats at dose...
To investigate the regulatory role of miRNA-26a in vascular smooth muscle cell (VSMC) calcification by regulating connective tissue growth factor (CTGF).Rat thoracic aorta VSMCs (A7r5 cells) with induced were treated AR234960 agonist or transfected miR-26a mimic, both treatments. Alizarin red staining was used to determine calcium deposition, and phosphatase (ALP) activity cells measured. The mRNA protein expressions miR-26a, OPG, OPN, BMP-2 collagen Ⅱ detected using qPCR Western blotting....
Background: Diabetic cardiomyopathy (DCM) could lead to changes in the structure and contractility of myocardium, which are initiated part by alterations energy substrates. The aim this research was detect effect berberine on myocardial lipidomics profiling diabetic rats using UPLC/Q-TOF/MS analysis, identify potential biomarkers for further therapy future.