A5068398293- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Sirtuins and Resveratrol in Medicine
- Peroxisome Proliferator-Activated Receptors
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Phytochemical Studies and Bioactivities
- Mangiferin and Mango Extracts
- Ginger and Zingiberaceae research
- Mitochondrial Function and Pathology
- Aquaculture disease management and microbiota
- Meteorological Phenomena and Simulations
- ATP Synthase and ATPases Research
- Neonatal Respiratory Health Research
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- Respiratory and Cough-Related Research
- Bioactive natural compounds
- Structural Integrity and Reliability Analysis
- Laser Applications in Dentistry and Medicine
- Traffic Prediction and Management Techniques
Hebei Meteorological Bureau
2019-2025
Beijing University of Chinese Medicine
2020-2024
Dalian University of Technology
2021
Xinxiang Central Hospital
2018
The incidence of type 1 diabetes mellitus (T1DM) is increasing year by year, gut microbiota considered to be closely related the occurrence and development T1DM in recent years. In this study, Sprague Dawley (SD) rats were intraperitoneally injected with 75mg/kg streptozotocin establish model, fecal samples collected DNA extracted, 16S rRNA microbial gene clone library constructed, lastly high-throughput sequencing bioinformatics analysis performed. results showed that abundances pathogenic...
The activation of thermogenic programs in brown adipose tissue (BAT) and white (WAT) provides a promising approach to increasing energy expenditure during obesity diabetes treatment. Although evidence has been found that rutin activates BAT against type 2 mellitus (T2DM), its potential mechanism is not completely understood. In this study, we focused on the modulating effect short-chain fatty acids (SCFAs) thermogenesis WAT, aiming elucidate molecular treatment T2DM. results showed could...
Abstract This study explored the complex evolution mechanism and fine‐scale structures of a quasi‐linear convective system (QLCS) in eastern Taihang Mountain from 1300 BST 12 to 0300 13 August 2018 by using Doppler radar data, high‐resolution surface observations sounding data. The QLCS which produced heavy precipitation was maintained as southeasterly being lifted when flowed over mesoscale outflow boundary (MOB) associated with cold pool. Topographic blocking effect environmental...
The incidence of liver-related complications in type 2 diabetes mellitus (T2DM) is rapidly increasing, which affects the physical and mental health T2DM patients. Mulberry leaf flavonoids (MLF) were confirmed to have certain effects on lowering blood glucose anti-inflammation. In this study, high-fat diet (HFD) + STZ method was used establish rat model MLF administered by gavage for eight weeks. During experiment, body weight level measured at different time points. pathological changes...
Qingwei San (QWS), one of classic Chinese Medicine prescripts, has been widely used to treat stomach heat syndrome which manifests oral ulcer (OU), periodontitis and upper gastrointestinal bleeding for seven hundred years. However, the therapeutic effects QWS on diabetic OU subjected are still ambiguous. In study, we investigated pharmacological mechanisms.The main components aqueous extract were analyzed by LC-MS, potential pathways targeting predicted network pharmacology. The db/db mice...
The current epidemic of type 2 diabetes mellitus (T2DM) significantly affects human health worldwide. Activation brown adipocytes and browning white are considered as a promising molecular target for T2DM treatment. Mulberry leaf, traditional Chinese medicine, has been demonstrated to have multi-biological activities, including anti-diabetic anti-inflammatory effects. Our experimental results showed that mulberry leaf alleviated the disorder glucose lipid metabolism in rats. In addition,...
Decreasing phosphorylation of AKT‑Foxo1 is closely associated with the onset insulin resistance and apoptosis during diabetic cardiomyopathy (DCM). Opening mitochondrial ATP‑sensitive potassium channels (mitoKATP) increases expression p‑AKT in process reperfusion injury. It was therefore hypothesized that opening mitoKATP may regulate signaling pathway improve cardiac function DCM. In present study, by diazoxide (DZX) found to attenuate cardiomyocyte db/db mice. DZX also significantly...
To determine the effects of a high-fat diet (HFD) on gut microbiome in rats, to explore relationship between intestinal flora and blood lipid profile. Sprague–Dawley rats were fed an HFD for four weeks induce hyperlipidemia, then 16S rRNA sequencing was used compare hyperlipidemic control diet-fed rats. The differed from that Bacterial species less abundant most affected by feeding, among which many pathogenic species, became significantly more abundant. Eighteen genera present different...
The purpose of this study is to investigate the relationship between susceptibility type 2 diabetes and gut microbiota in rats explore potential mechanism involved.Thirty-two SPF-grade SD were raised as donor rats, divided into control, mellitus (T2DM, fasting blood glucose ≥ 11.1 mmol/L), Non-T2DM (fasting < mmol/L) groups. Feces collected prepared fecal bacteria supernatants Diab (fecal supernatant T2DM group rats), Non Con control rats). Another seventy-nine separated normal saline (NS)...
Abstract Background Whether portal venous gas (PVG) is a sign of severe neonatal necrotizing enterocolitis (NEC) and predicts poor prognosis remains uncertain. Methods Patients from two centres were randomly assigned to training set or validation set. A nomogram model for predicting NEC was developed on the basis independent risk factors selected by least absolute shrinkage selection operator (LASSO) regression analysis multivariate logistic analysis. The evaluated based area under curve...
Mulberry (Morus alba L.) leaf, as a medicinal and food homologous traditional Chinese medicine, has clear therapeutic effect on type 2 diabetes mellitus (T2DM), yet its underlying mechanisms have not been totally clarified. The study aimed to explore the mechanism of mulberry leaf in treatment T2DM through tandem mass tag (TMT)-based quantitative proteomics analysis skeletal muscle.The anti-diabetic activity extract (MLE) was evaluated by using streptozotocin-induced diabetic rats at dose...
To observe the relationship between different stages of type 2 diabetes mellitus (T2DM) and intestinal flora verify its underlying mechanism. T2DM rats were generated by high-fat diet (HFD) combined with intraperitoneal streptozotocin (STZ) injection. The divided into four groups: control group (fed normal feed for 1 month), HFD (HFD STZ blood glucose ≥11.1 mM), unformed model (Un-mod) <11.1 mM). Feces collected, bacterial communities in fecal samples analyzed 16S rRNA gene sequencing....
Objectives Stiffened panels are widely used as thin-walled load-bearing components, and the design space can be significantly increased when stiffened path is curvilinear. Due to functional requirements of structures, there a large number structures with cutouts in structural aviation, aerospace, shipbuilding other fields, which leads significant reduction bearing capacity structure. Although curved stiffening method has great potential improving performance open structure, sharp increase...
Objective To evaluate the short-term outcomes after femtosecond laser-assisted laser in situ keratomileusis (FEMTO-LASIK) highly astigmatic myopes.Methods Eyes with more than 2.0 diopters (D) of astigmatism were identified from patient records.The mean preoperative cylinder was-2.45±0.62 DC myopic eyes.Patients examined preoperatively and 3 months postoperatively.Laser was performed a WaveLight FS200 eye-Qexcimer laser.Preoperative postoperative refractions converted to vector values.Induced...
The accurate prediction of wind speed is an important part the weather forecasting service for Winter Olympic Games. Zhangjiakou zone Beijing 2022 Games located in complex terrain Dama Mountains, and current numerical forecasts have large deviations small-scale terrain. Based on unsupervised machine learning method, this paper performs historical modeling basis five element two nine stations Zone Games, thus achieving objective correction to average winds extreme winds. results show that...
Using conventional meteorological observation data, automatic weather station radar data and Final Operational Global Analysis (FNL) focusing on the local rainstorms of Hebei province in process subtropical high moving north 20-22 July 2017, meso-scale characteristics reasons are analyzed this paper.Firstly, belong to heavy rain caused by summer monsoon north, distribution rainfall is extremely uneven, with 3 strong centers located Qinhuangdao, Shijiazhuang, Langfang.Secondly, difference...
Abstract Purpose To investigate the relationship between susceptibility to type 2 diabetes and gut microbiota explore potential mechanisms. Methods Thirty-two SPF SD rats were raised as donor rats, divided into control, mellitus (T2DM) Un-mod groups. Feces collected prepared fecal bacteria supernatant A (T2DM group), B (Un-mod group) Con (control group). Another seventy-nine separated normal saline (NS) ABX NS groups given antibiotics solution saline, respectively. And then, group randomly...
Background: Activation of brown/beige adipocytes is a novel and promising strategy for the treatment obesity. Mulberry leaf flavonoids (MLF) extracted from mulberry leaf, traditional Chinese medicine, have positive effects on anti-inflammatory, antioxidant improving insulin resistance, yet its therapeutic effect obesity still unclear.Objective: In present study, we focused MLF fat browning, elucidated underlying mechanism.Methods: Db/db mice 3T3-L1 cell models were used to demonstrate that...