A5100376120- Kawasaki Disease and Coronary Complications
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Cardiac Ischemia and Reperfusion
- Viral Infections and Immunology Research
- ATP Synthase and ATPases Research
- Inflammasome and immune disorders
- Cardiac Structural Anomalies and Repair
- Diet and metabolism studies
- Cancer-related gene regulation
- Heart Failure Treatment and Management
- Medicinal Plants and Bioactive Compounds
- Chronic Disease Management Strategies
- Immunotherapy and Immune Responses
- Congenital heart defects research
- Tracheal and airway disorders
- Metabolomics and Mass Spectrometry Studies
- Bioactive natural compounds
- Polyomavirus and related diseases
- Celiac Disease Research and Management
- Autophagy in Disease and Therapy
- Vibrio bacteria research studies
- Sirtuins and Resveratrol in Medicine
Chinese PLA General Hospital
2017-2024
National Clinical Research
2024
Institute of Art
2023
Xilinx (United States)
2023
China Three Gorges University
2021-2023
Children's Hospital of Fudan University
2023
Nanjing Medical University
2022
Beijing Friendship Hospital
2022
Capital Medical University
2022
Shandong University
2021
Context Icariin (ICA) is the main active ingredient of Epimedium brevicornu Maxim (Berberidaceae), which used in immune, reproductive, neuroendocrine systems, and anti-aging.Objective To evaluate effect ICA on natural aging rat.Materials methods 16-month-old Sprague–Dawley (SD) rats were randomly divided into aging, low high-dose groups (n = 8); 6-month-old taken as adult control 8). Rats fed regular feed (aging control) or containing (ICA 2 6 mg/kg group) for 4 months. HE Nissl staining to...
Coronary heart disease (CHD) brings a heavy burden to society worldwide. Novel and minimally invasive biomarkers for the risk evaluation of CHD are urgently needed. Previous study has revealed that blood-based hypomethylation β-actin (ACTB) was associated with increased stroke, but not reported in yet.We aimed explore association between ACTB methylation case-control Chinese population.The level quantitatively determined by mass spectrometry 281 patients 272 controls. The estimated logistic...
Decreasing phosphorylation of AKT‑Foxo1 is closely associated with the onset insulin resistance and apoptosis during diabetic cardiomyopathy (DCM). Opening mitochondrial ATP‑sensitive potassium channels (mitoKATP) increases expression p‑AKT in process reperfusion injury. It was therefore hypothesized that opening mitoKATP may regulate signaling pathway improve cardiac function DCM. In present study, by diazoxide (DZX) found to attenuate cardiomyocyte db/db mice. DZX also significantly...
Objective . To investigate the association between aspartate aminotransferase (AST)/alanine (ALT) ratio (AST/ALT ratio, AAR) and intravenous immunoglobulin (IVIG) resistance, coronary artery lesions (CAL), aneurysms (CAA) in children with Kawasaki disease (KD). Design We retrospectively studied 2678 KD divided them into two groups: a low-AAR group high-AAR median AAR of 1.13 as cut-off point. The differences laboratory data, clinical manifestations, damage rates were compared groups. Results...
Abstract Background Kawasaki disease (KD) is the leading cause of acquired heart in children, and steadily increasing prevalence East Asia. KD often complicated by coronary artery damage, including dilatation and/or aneurysms. Aspirin used with intravenous immunoglobulin (IVIG) to prevent abnormalities KD. However, role optimal dose aspirin remain controversial. Identifying acute phase will facilitate development a more appropriate treatment strategy improving outcome Methods A total 2369...
Panax japonicus is the dried rhizome of C.A. Mey. (Araliaceae). Saponins from (SPJ) exhibit anti-oxidative and anti-aging effects.We evaluated neuroprotective effects SPJ on aging rats.Sprague-Dawley rats (18-months-old) were randomly divided into groups (n = 8). Five-month-old taken as adult control The fed a normal chow diet or SPJ-containing (10 30 mg/kg) for 4 months. An in vitro model was established by d-galactose (d-Gal) SH-SY5Y cell line pretreated with (25 50 µg/mL). neuroprotection...
Abstract Previous studies have shown that the expression of inwardly rectifying potassium channel 6.1 (Kir6.1) in heart mitochondria is significantly reduced type 1 diabetes. However, whether its and function are changed what role it plays 2 diabetic cardiomyopathy (DCM) not been reported. This study investigated mechanism Kir6.1 DCM. We found cardiac DCM mice were decreased. generated overexpressing or lacking gene specifically heart. overexpression improved dysfunction Cardiac‐specific...
Blood DNA methylation was associated with coronary heart disease (CHD) risk in Caucasians. We investigated the association between peripheral blood at reported loci and CHD Chinese population.The integrin subunit beta 2 (ITGB2) gene identified 196 cases 184 controls, its level determined by mass spectrometry. Logistic regression used to assess association.Hypomethylation of ITGB2 significantly failure NYHA Ⅰ&Ⅱ patients minor medium cardiac function impairment (ITGB2_CpG_11/cg08422803, OR per...
Abstract Background miRNAs play important roles in a variety of diseases. Thus, the association between miRNA‐196a2 rs11614913 T>C polymorphism and Kawasaki disease susceptibility is still unknown. Methods We included 532 children with 623 healthy from South China, their DNA was extracted for genotyping by TaqMan methodology. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated to estimate strength association. Results No significant associations observed polymorphisms risk...
Abstract Background Visceral adipose tissue–derived serine protease inhibitor (vaspin), a secretory adipokine, protects against insulin resistance. Recent studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and myocardial ischemia-reperfusion injury atherosclerosis. However, it remains unclear whether exerts specific effects on pathological cardiac hypertrophy. Methods An vivo study was conducted using hypertrophy model established by...
Abstract Background Novel molecular biomarkers for the risk assessment and early detection of coronary heart disease (CHD) are urgently needed prevention. Altered methylation ATP-binding cassette subfamily G member 1 ( ABCG1 ) has been implicated in CHD but was mostly studied Caucasians. Exploring potential relationship between blood among Chinese population would yield valuable insights. Methods Peripheral samples were obtained from a case–control study (287 patients vs. 277 controls)...
Abstract Background Kawasaki disease (KD), which is characterized by vasculitis, prone to occur in patients under 5 years of age, has an ambiguous etiology, and displays coronary artery lesions as the chief complication. Previous studies have linked miRNA‐149 cancers, rs2292832 T>C related allergic diseases inflammatory bowel disease, both show immune system disorders disease. Therefore, we performed a study concentrating on association between polymorphism KD susceptibility. Methods The...
Abstract Background Ketone body metabolism can improve cardiomyocytes and reduce myocardial oxygen consumption; however, its role in the short-term prognosis of patients with acute infarction combined heart failure has not been clearly elucidated. The aim this study was to investigate effect β-hydroxybutyric acid, main component ketone bodies, on failure. Methods This a retrospective observational that enrolled admitted Qilu Hospital Shandong University for between January 1, 2019, December...
Abstract Background Early detection could significantly improve the prognosis of coronary heart disease (CHD). In-invitro diagnostic technique may provide a solution when sufficient biomarkers be identified. Pertinent associations between blood-based aberrant DNA methylation and smoking, pathogenesis atherosclerosis, CHD have been robustly demonstrated replicated, but that studies in Chinese populations are rare. The aryl-hydrocarbon receptor repressor ( AHRR ) cg05575921 6p21.33 cg06126421...
Abstract Background Manifesting as acute rash, fever and vasculitis, belonging to autoimmune syndrome, Kawasaki disease(KD) is prone occur in infants young children. Males females affected by KD at a ratio of 1.4 1.7: 1. known own many common clinical manifestations complications, like coronary artery lesion(CAL) aneurysm(CAA). Polymorphisms the rs6505162 locus miRNA-423 gene are associated with enhancive susceptibility disease alterations four cytokines IL-4., IL-10, IL-21, IL-22 early...
Abstract Background: Early detection could significantly improve the prognosis of coronary heart disease (CHD). In-invitro diagnostic technique may provide a solution when sufficient biomarkers be identified. Pertinent associations between blood-based aberrant DNA methylation and smoking, pathogenesis atherosclerosis, CHD have been robustly demonstrated replicated, but that studies in Chinese populations are rare. The aryl-hydrocarbon receptor repressor ( AHRR ) cg05575921 6p21.33 cg06126421...
Inflammation, especially chronic inflammation, is closely linked to tumor development. As essential inflammatory cytokines, the interleukin family plays a key role in infections and malignancies. The interleukin-1 receptor antagonist (IL-1Ra) first naturally occurring be discovered, its action compete with (IL-1) for binding receptor. In recent years, as research on gene polymorphisms of cells has been identified, IL-1Ra are associated an increased risk carcinogenesis, squamous cell...
Congenital heart disease (CHD) is a common birth defect, and frequently accompanied with extracardiac malformations (ECM). Uncovering the genetic etiology of CHD may have meaningful impact on management. De novo variants been proven to be associated CHD.Whole exome sequencing was performed for 4 unrelated families malformations, candidate genes were screened by using stringent bioinformatics analysis, obtained confirmed Sanger sequencing. RT-PCR used investigate influence splice variant...
Abstract This retrospective study explored the changes in biomarkers indicators and prognosis COVID-19 patients with mental disorders (n = 60) from author’ Hospital between 2/13/2020 4/15/2020. Significant differences before after negative conversion were observed lymphocytes, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte aspartate aminotransferase, albumin, albumin/globulin direct bilirubin, alkaline phosphatase, uric acid, high-density lipoprotein cholesterol, ApoA1 (all P <...