A5017975992- Cancer-related molecular mechanisms research
- Head and Neck Cancer Studies
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Salivary Gland Disorders and Functions
- Cancer-related gene regulation
- Cancer Research and Treatments
- Polyomavirus and related diseases
- Cutaneous lymphoproliferative disorders research
- RNA modifications and cancer
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- interferon and immune responses
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Cell Adhesion Molecules Research
Nanjing Medical University
2018-2024
Shanghai First People's Hospital
2012
Abstract Objectives Our aim was to identify and prevalidate a set of salivary proteins that can distinguish oral squamous cell carcinomas (OSCC) patients from healthy individuals with potentially malignant disorders (OPMD). Subjects methods Proteomes 60 saliva samples individuals, OPMD patients, OSCC were assayed using the isobaric tags for relative absolute quantitation (iTRAQ) method. Enzyme‐linked immunosorbent assay (ELISA) used candidate biomarkers in an independent sample ( n = 90)....
Oral squamous cell carcinoma (OSCC) is the most common cancer in oral and maxillofacial tissue. This study aimed to investigate expression of SLC3A2 human OSCC tissues its regulatory roles OSCC.The was assessed using immunohistochemistry. The proliferation, migration, invasion cells were evaluated after knockdown SLC3A2.The higher than that normal epithelial cells. had levels adjacent tissues. Upregulation associated with advanced stages poor survival patients. In vitro experiments showed...
Biomarkers are biochemical indicators that can identify changes in the structure or function of systems, organs, cells and be used to monitor a wide range biological processes, including cancer. Interleukin-1 receptor antagonist (IL1RA) is an important inflammatory suppressor gene tumor biomarker. The goal this study was investigate expression IL1RA, its probable carcinogenic activity, diagnostic targets oral squamous cell carcinoma (OSCC).
Abstract Objective: This study aimed to investigate the relationship between focal adhesion kinase expression and clinicopathological factors, cell apoptosis proliferation, overall survival, in laryngeal squamous carcinoma. Methods: Immunohistochemical staining was used detect of proliferating nuclear antigen tissue samples. Apoptotic cells were assessed using terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labelling (‘TUNEL’) method. Results: The proportion...
Inflammation, especially chronic inflammation, is closely linked to tumor development. As essential inflammatory cytokines, the interleukin family plays a key role in infections and malignancies. The interleukin-1 receptor antagonist (IL-1Ra) first naturally occurring be discovered, its action compete with (IL-1) for binding receptor. In recent years, as research on gene polymorphisms of cells has been identified, IL-1Ra are associated an increased risk carcinogenesis, squamous cell...
<title>Abstract</title> <bold>Background: </bold>Biomarkers are biochemical indicators that can identify changes in the structure or function of systems, organs, cells and be used to monitor a wide range biological processes, including cancer. Interleukin-1 receptor antagonist (IL1RA) is an important inflammatory suppressor gene tumor biomarker. The goal this study was investigate expression IL1RA, its probable carcinogenic activity, diagnostic targets oral squamous cell carcinoma (OSCC)....