A5010416559- interferon and immune responses
- Invertebrate Immune Response Mechanisms
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- Neurobiology and Insect Physiology Research
- Ion Channels and Receptors
- Aquaculture disease management and microbiota
- Neural dynamics and brain function
- Ion Transport and Channel Regulation
- Zebrafish Biomedical Research Applications
- Cancer, Hypoxia, and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Insect symbiosis and bacterial influences
- Telomeres, Telomerase, and Senescence
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Functional Brain Connectivity Studies
- NF-κB Signaling Pathways
- EEG and Brain-Computer Interfaces
- Signaling Pathways in Disease
Bioscientifica (United Kingdom)
2023
Stockton University
2019
Breast Cancer Now
2015-2018
Institute of Cancer Research
2015-2018
University of Oxford
2014
NFAT-dependent gene expression is essential for the development and function of nervous, immune, cardiovascular systems kidney, bone, skeletal muscle [1Hogan P.G. Chen L. Nardone J. Rao A. Transcriptional regulation by calcium, calcineurin, NFAT.Genes Dev. 2003; 17: 2205-2232Crossref PubMed Scopus (1554) Google Scholar]. Most NFAT protein resides in cytoplasm because extensive phosphorylation, which masks a nuclear localization sequence. Dephosphorylation Ca2+-calmodulin-activated...
Abstract Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging age-related disease, SASP-related inflammation is thought to contribute tissue dysfunction diseased animals. However, whether how SASP factors influence regenerative capacity of tissues remains unclear. Here, using intestinal organoids as a model regeneration, we show that released by senescent fibroblasts deregulate stem cell activity differentiation ultimately impair crypt...
In many tissues, stem cell (SC) proliferation is dynamically adjusted to regenerative needs. How SCs adapt their metabolism meet the demands of and how changes in such adaptive mechanisms contribute age-related dysfunction remain poorly understood. Here, we identify mitochondrial Ca2+ uptake as a central coordinator SC metabolism. Live imaging genetically encoded metabolite sensors intestinal (ISCs) Drosophila reveals that transiently adapts electron transport chain flux match energetic...
Abstract Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensatory proliferation, morphology and cell migration. How caspases are activated under conditions process a selective set of substrates without killing the remain enigmatic. Here we find that Drosophila unconventional myosin CRINKLED (CK) selectively interacts with initiator caspase DRONC regulates some its functions. Loss CK arista, border cells or proneural clusters wing imaginal discs...
The importance of diverse lifestyle factors in sustaining cognition during aging and delaying the onset decline Alzheimer's disease related dementias cannot be overstated. We explored influence cognitive, social, physical on resting-state lagged linear connectivity (LLC) high-density electroencephalography (EEG) adults, ages 35-75 years. Diverse build cognitive reserve (CR), protecting presence brain decline. Differences LLC were examined between high- low-CR groups formed using exercise...